The Effects of Physical Exercise on the Serum Iron Profile in Spontaneously Hypertensive Rats

Frank, Miriam Kannebley; Esteves, Andrea Maculano; Lopes, Carlos Renato; Cavagnolli, Daniel Alves; Tufik, Sérgio; Mello, Marco Túlio de

doi:10.1007/s12011-011-9188-5

Cited by 5 publications

(3 citation statements)

References 18 publications

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“…8 The effects of the hypertensive state and anti-hypertensive treatments on iron metabolism have not been rigorously explored. 29 In the present study, we found significantly lower levels of serum and liver iron in SHRs compared with WKY rats, indicating that hypertension is associated with systemic lowiron status. These results are consistent with a previous study showing that serum iron levels were decreased in SHRs compared with normotensive animals.…”

Section: Discussionsupporting

confidence: 55%

“…Essential hypertension is a multifactorial disease that accounts for 95% of hypertensive patients 8 . The effects of the hypertensive state and anti‐hypertensive treatments on iron metabolism have not been rigorously explored 29 . In the present study, we found significantly lower levels of serum and liver iron in SHRs compared with WKY rats, indicating that hypertension is associated with systemic low‐iron status.…”

Section: Discussionmentioning

confidence: 48%

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Influence of prazosin on systemic iron levels and the associated iron metabolic alterations in spontaneously hypertensive rats

Chang

Zhang

Zhen

et al. 2022

Pharmacology Res & Perspec

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The relationship between cardiovascular diseases and iron disorders has gained increasing attention; however, the effects of hypotensive drugs on iron metabolic alterations in hypertension are not well understood. The purpose of this study was to investigate iron metabolic changes after prazosin treatment of spontaneously hypertensive rats (SHRs) and Wistar–Kyoto (WKY) rats. Our second objective was to examine the effects of hypertension and anti‐hypertensive drugs on bone formation and resorption. SHRs and WKY rats were randomized into either prazosin‐treated groups (WKY + PZ and SHR + PZ) or untreated groups (WKY and SHR). After 7 days of intragastric prazosin administration, the rats were sacrificed for analysis; blood samples and organs (the duodenum, liver, kidneys, spleen, and femur) were collected. Both WKY + PZ and SHR groups exhibited iron deficiency in the serum and liver. Prazosin increased the iron levels in the bone tissue of SHRs. Prazosin stimulated the expression of hepcidin mRNA in the liver of SHRs and inhibited the expression of this iron‐regulatory hormone in WKY rats. FPN1 expression in the duodenum was increased significantly in SHRs, however markedly decreased after prazosin treatment. The expression of TLR4 and Ctsk was enhanced in the bone tissue of SHRs, whereas CLC‐7 expression was inhibited. Both hypotension and hypertension can lead to iron deficiency. Treatment with prazosin restored iron homeostasis in SHRs. The inverse impacts of prazosin on hepatic hepcidin expression in SHRs versus WKY rats indicates differing iron regulatory mechanisms between hypertensive and normal animals. The osteoclast activity was found to be enhanced in SHRs. Further study is needed to address whether the changes in osteoblast and osteoclast activity in SHRs correlates with the effects on iron metabolism.

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Section: Discussionsupporting

confidence: 55%

Section: Discussionmentioning

confidence: 48%

Influence of prazosin on systemic iron levels and the associated iron metabolic alterations in spontaneously hypertensive rats

Chang

Zhang

Zhen

et al. 2022

Pharmacology Res & Perspec

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“…In the present study, we observed that the rats in the SHR group had a higher serum iron concentration, and a lower transferrin concentration, compared to the WK group. Other researchers have also observed higher serum iron concentrations in SHRs compared to WK rats (Frank et al, 2012). One study (Ward et al, 2014) suggested that some patients with RLS may have normal serum iron concentration; however, at the central level the concentration may be low.…”

Section: Resultsmentioning

confidence: 96%

Protein tyrosine phosphatase receptor type delta (PTPRD) gene in an animal model of restless legs syndrome

Morais

Franco

Holanda

et al. 2022

Journal of Sleep Research

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The pathophysiology of the restless legs syndrome (RLS) is related to dopaminergic dysfunction, reduced iron and variations in gene expression, such as the protein tyrosine phosphatase receptor type delta gene (PTPRD). Animal models could be key to achieving a mechanistic understanding of RLS and to facilitate efficient platforms for evaluating new therapeutics. Thus, the aim of this study was to evaluate the expression of PTPRD, of genes and proteins associated with RLS, the sleep patterns and the cardiovascular parameters in an animal model of RLS (spontaneously hypertensive rat [SHR]). Rats were divided into two groups: (i) Wistar-Kyoto and (ii) SHR. Cardiovascular parameters were assessed by tail plethysmography. Polysomnography was used to analyse the sleep pattern (24 h). For the PTPRD analyses, quantitative polymerase chain reaction (qPCR) and indirect enzyme-linked immunosorbent assay (ELISA) techniques were used. To evaluate the tyrosine hydroxylase enzyme, dopamine transporter (DAT) and type 2 dopaminergic receptor, qPCR and Western Blotting techniques were used. For the quantification of iron, ferritin and transferrin, the ELISA method was used. SHRs had higher blood pressure, alterations in sleep pattern, lower expression of protein content of PTPRD, lower expression of DAT, and lower serum concentrations of ferritin. These data suggest that the behavioural, physiological, and molecular changes observed in SHRs provide a useful animal model of RLS, reinforcing the importance of this strain as an animal model of this sleep disorder.

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The Correlation Between COVID-19 Infection and Restless Legs Syndrome

Esteves

Franco

Morais

2023

Progress in Sleep Research

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The Effects of Physical Exercise on the Serum Iron Profile in Spontaneously Hypertensive Rats

Cited by 5 publications

References 18 publications

Influence of prazosin on systemic iron levels and the associated iron metabolic alterations in spontaneously hypertensive rats

Influence of prazosin on systemic iron levels and the associated iron metabolic alterations in spontaneously hypertensive rats

Protein tyrosine phosphatase receptor type delta (PTPRD) gene in an animal model of restless legs syndrome

The Correlation Between COVID-19 Infection and Restless Legs Syndrome

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