The Effects of Probiotic Supplementation on Genetic and Metabolic Profiles in Patients with Gestational Diabetes Mellitus: a Randomized, Double-Blind, Placebo-Controlled Trial

Babadi, Mahtab; Kazemi, Ahmad; Aghadavood, Esmat; Samimi, Mansooreh; Kavossian, Elham; Bahmani, Fereshteh; Mafi, Alireza; Shafabakhsh, Rana; Satari, Mahbobeh; Asemi, Zatollah

doi:10.1007/s12602-018-9490-z

Cited by 59 publications

(111 citation statements)

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“…Yogurt enriched with probiotics was ingested by study participants in two of the studies 27,38 , and synbiotic foods were used in another 39 . In nine studies, probiotic capsules were given daily 28,[40][41][42][43][44][45][46][47] , while a synbiotic capsule was ingested daily in the remaining three 28,48,50 . The basic characteristics, number of subjects, experiment duration, type of intervention, and carbohydrate metabolism parameters are presented in Tables 3 and 4.…”

Section: Resultsmentioning

confidence: 99%

“…Participants were recruited from the Asian [26][27][28]38,39,[42][43][44][45][46]48,49 www.nature.com/scientificreports/ designed as randomized controlled trials. Interventions were based on supplementation of probiotic bacteria, such as: Lactobacillus acidophilus [26][27][28]38,[42][43][44][45][46] , Lactobacillus casei 26,28,42 , Lactobacillus delbrueckii bulgaricus 27,43,44 , Lactobacillus fermentum 28,45 , Lactobacillus gasseri 45 , Lactobacillus paracasei 44 , Lactobacillus plantarum 44,45 , Lactobacillus salivarius 40,41 , Lactobacillus sporogenes 39 , Bifidobacterium animalis 38,43 , Bifidobacterium bifidum 26,28,42,46 , Bifidobacterium breve 44 , Bifidobacterium infantis 44 , Bifidobacterium lactis 27 , Bifidobacterium longum 44 , Streptococcus thermophilus …”

Section: Resultsmentioning

confidence: 99%

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Improvement of glucose metabolism in pregnant women through probiotic supplementation depends on gestational diabetes status: meta-analysis

Łagowska¹,

Malinowska²,

Zawieja³

et al. 2020

Sci Rep

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The aim of this study was to assess the effects of probiotic and synbiotic supplementation on glucose metabolism in pregnant women using data from randomized controlled trials. Furthermore, this meta-analysis examines whether the observed effects depend on the presence or absence of gestational diabetes mellitus (GDM), and if the effect is dependent on the type of supplement used (probiotic or synbiotic). We performed a literature search of databases (Medline, Scopus, Web of Knowledge, and Cochrane Library) and identified all relevant randomized controlled trials (RCTs) published prior to May 2019. We compared the effects of probiotic supplementation with the administration of placebos in pregnant women with and without GDM. The systematic review and meta-analysis protocol were registered in the International Prospective Register of Systematic Reviews as number CRD 42019111467. 1119 study participants from 15 selected studies were included. The participants in four studies did not have GDM (being recruited to the study before week 20 of pregnancy) and the participants in the rest of the studies were diagnosed with GDM between weeks 24 and 28 of gestation. The meta-analysis showed that supplementation lowers serum glucose, insulin levels, and HOMA-IR index, but only in pregnant women with GDM. Moreover, both probiotics and synbiotics lower serum insulin level and HOMA-IR index, but the glucose lowering effect is specific only to probiotics and not synbiotics. Probiotic supplementation may improve glucose metabolism in pregnant women with GDM. There is a need for more RCT studies with larger groups to better estimate this effect.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Improvement of glucose metabolism in pregnant women through probiotic supplementation depends on gestational diabetes status: meta-analysis

Łagowska¹,

Malinowska²,

Zawieja³

et al. 2020

Sci Rep

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show abstract

“…After reading the titles and abstracts, 54 studies were selected for further review. Finally, thirteen studies met our inclusion criteria [22][23][24][25][26][27][28][29][30][31][32][33][34]. The detailed process of the search strategy is described in Figure 1.…”

Section: Study Selection and Characteristicsmentioning

confidence: 99%

“…Figure 2 shows the risk of bias of the included studies. Twelve studies [22][23][24][25][26][27][28][29][31][32][33][34] reported methods for generating random sequences, which were mainly computerized randomization methods. Seven studies mentioned the use of allocation concealment, and three of these studies described specific methods [25,27,29].…”

Section: Study Selection and Characteristicsmentioning

confidence: 99%

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Effects of Nutritional Strategies on Glucose Homeostasis in Gestational Diabetes Mellitus: A Systematic Review and Network Meta-Analysis

Jin

Sha

Dong

et al. 2020

Journal of Diabetes Research

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Background. Gestational diabetes mellitus (GDM) is one of the most common complications of pregnancy, and nutritional therapy is the basis of GDM treatment. However, the effects of different forms of nutritional supplementation on improving gestational diabetes are uncertain. Objective. We conducted a network meta-analysis to evaluate the effects of supplementation with different nutrients on glucose metabolism in women with GDM. Methods. We conducted a literature search using PubMed, EMBASE, and the Cochrane Library to identify randomized controlled trials (RCTs) comparing the differences between different nutritional strategies in women with GDM. The Cochrane tool was used to assess the risk of bias. Pairwise meta-analysis and network meta-analysis were used to compare and rank the effects of nutritional strategies for the improvement of fasting plasma glucose (FPG), serum insulin, and homeostasis model assessment-insulin resistance (HOMA-IR). Results. We included thirteen RCTs with a total of 754 participants. Compared with placebo, omega-3, magnesium, vitamin D, zinc, and probiotics were more beneficial for improving FPG, serum insulin, and HOMA-IR. Network analysis showed that vitamin D supplementation was superior to omega-3 (-3.64 mg/dL, 95% CI: -5.77 to -1.51), zinc (-5.71 mg/dL, 95% CI: -10.19 to -1.23), probiotics (-6.76 mg/dL, 95% CI: -10.02 to -3.50), and placebo (-12.13 mg/dL, 95% CI: -14.55 to -9.70) for improving FPG. Magnesium supplementation was more beneficial for decreasing serum insulin compared with probiotics (-5.10 μIU/mL, 95% CI: -9.32 to -0.88) and placebo (-7.80 μIU/mL; 95% CI-11.95, -3.65). Vitamin D was more effective than probiotics (-0.99, 95% CI: -1.84 to -0.14) and placebo (-1.80, 95% CI: -2.45 to -1.16) for improving HOMA-IR. Conclusion. Vitamin D supplementation significantly reduced FPG and regulated HOMA-IR. Magnesium supplementation was superior in decreasing serum insulin than supplementation with other nutrients. Nutrient supplementation seemed to have an effect on glucose homeostasis maintenance in patients with GDM and may be considered an adjunctive therapy.

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Intestinal flora and pregnancy complications: Current insights and future prospects

Tian,

Zhang,

Yao

et al. 2024

iMeta

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Numerous studies have demonstrated the pivotal roles of intestinal microbiota in many physiopathological processes through complex interactions with the host. As a unique period in a woman's lifespan, pregnancy is characterized by changes in hormones, immunity, and metabolism. The gut microbiota also changes during this period and plays a crucial role in maintaining a healthy pregnancy. Consequently, anomalies in the composition and function of the gut microbiota, namely, gut microbiota dysbiosis, can predispose individuals to various pregnancy complications, posing substantial risks to both maternal and neonatal health. However, there are still many controversies in this field, such as “sterile womb” versus “in utero colonization.” Therefore, a thorough understanding of the roles and mechanisms of gut microbiota in pregnancy and its complications is essential to safeguard the health of both mother and child. This review provides a comprehensive overview of the changes in gut microbiota during pregnancy, its abnormalities in common pregnancy complications, and potential etiological implications. It also explores the potential of gut microbiota in diagnosing and treating pregnancy complications and examines the possibility of gut‐derived bacteria residing in the uterus/placenta. Our aim is to expand knowledge in maternal and infant health from the gut microbiota perspective, aiding in developing new preventive and therapeutic strategies for pregnancy complications based on intestinal microecology.

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The Effects of Probiotic Supplementation on Genetic and Metabolic Profiles in Patients with Gestational Diabetes Mellitus: a Randomized, Double-Blind, Placebo-Controlled Trial

Cited by 59 publications

References 47 publications

Improvement of glucose metabolism in pregnant women through probiotic supplementation depends on gestational diabetes status: meta-analysis

Improvement of glucose metabolism in pregnant women through probiotic supplementation depends on gestational diabetes status: meta-analysis

Effects of Nutritional Strategies on Glucose Homeostasis in Gestational Diabetes Mellitus: A Systematic Review and Network Meta-Analysis

Intestinal flora and pregnancy complications: Current insights and future prospects

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