The effects of recombinant human epidermal growth factor containing ointment on wound healing and post inflammatory hyperpigmentation prevention after fractional ablative skin resurfacing: A split‐face randomized controlled study

Techapichetvanich, Thanya; Wanitphakdeedecha, Rungsima; Iamphonrat, Thanawan; Phothong, Weeranut; Eimpunth, Sasima; Hidajat, Inneke Jane; Manuskiatti, Woraphong

doi:10.1111/jocd.12691

Cited by 28 publications

(36 citation statements)

References 26 publications

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“…In this study, we used EGF agent in the form of ointment. EGF ointment has been shown to be effective for wound healing without systemic side-effects in multiple clinical trials of dermatologic field [26,27]. In addition, the formulation of ointment is commercially available, which reduces the inconvenience of drug preparation in the form of eye drop.…”

Section: Discussionmentioning

confidence: 99%

Effect of epidermal growth factor ointment on persistent epithelial defects of the cornea

Moon

Yoon

et al. 2020

BMC Ophthalmol

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Background: Healthy corneal epithelium acts as a barrier against damage to the deeper structures in the eye. Failure in the mechanisms of corneal epithelization can lead to persistent epithelial defects of the cornea (PEDs) and can compromise its function. Epidermal growth factor (EGF) promotes the proliferation, migration, and differentiation of epithelial cells, endothelial cells, and fibroblasts during wound healing and may be beneficial in treating patients with PEDs. We, therefore, investigated the effect of EGF ointment on patients with PEDs. Methods: Fifteen patients with PEDs refractory to conventional treatment were treated twice a day with EGF ointment. Patient demographics and comorbidities were noted. The epithelial healing time was determined along with the primary outcome measures in the areas of the epithelial defects, visual acuity, visual analog scale (VAS) scores, and esthesiometer scores 1 month and 2 months after treatment.Results: Five eyes of herpetic keratitis (33.3%), 3 eyes of dry eye disease (20.0%), 3 eyes of bacterial keratitis (20.0%), 2 eyes of limbal stem cell deficiency (13.3%), 1 eye of diabetic neurotrophic keratitis (6.7%), and 1 eye of filamentary keratitis (6.7%) were associated with PEDs, respectively. Two months following treatment with EGF ointment, there was a reduction in the area of the epithelial defects (5.7 ± 3.9 to 0.1 ± 0.3 mm 2 ) as well as a significant improvement in best-corrected visual acuity (0.9 ± 0.8 to 0.6 ± 0.5 LogMAR) and VAS scores (4.5 ± 1.2 to 2.5 ± 0.7) in 12 eyes (80%). Among these cases, the mean epithelial healing time was 5.5 ± 1.8 weeks. Amniotic membrane transplantation was performed on the remaining 3 (20.0%) patients that did not respond to EGF treatment.Conclusions: EGF ointment could reduce symptoms and promotes corneal epithelialization of refractory PEDs. It may, therefore, be well-tolerated and a potentially beneficial addition in the management of refractory PEDs.

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Section: Discussionmentioning

confidence: 99%

Effect of epidermal growth factor ointment on persistent epithelial defects of the cornea

Moon

Yoon

et al. 2020

BMC Ophthalmol

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“…The type of vehicle may affect the penetration of active ingredients after AFLs. From a study using creams containing epidermal growth factors (EGFs) as an active ingredient, liquid‐type formulation showed higher filling of MTZs thus improving the delivery …”

Section: Discussionmentioning

confidence: 99%

The effect of human umbilical cord blood–derived mesenchymal stem cell media containing serum on recovery after laser treatment: A double‐blinded, randomized, split‐face controlled study

Kim

et al. 2019

J of Cosmetic Dermatology

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Background Ablative CO2 fractional laser (AFL) is a common cosmetic procedure to improve skin laxity. However, due to prolonged downtime and the risk of postinflammatory hyperpigmentation, laser‐assisted delivery of active ingredients as post–laser treatment has gained interest in past years. Among various active ingredients, human umbilical cord blood–derived mesenchymal stem cells (hUCBMSCs) can be a promising agent promoting skin regeneration. Aims We evaluated the efficacy and safety of a human cord blood cell–conditioned media containing serum and cream on patients who underwent AFL treatment. A randomized, investigator‐blinded, prospective, split‐face comparison study was conducted. Materials and Methods Twenty‐three patients who underwent AFL on both cheeks applied a human umbilical cord blood–derived mesenchymal stem cell (hUCBMSC)‐conditioned media containing cream with or without stem cell containing serum application. As a primary outcome measure, we evaluated the total area of microcrusts and post‐treatment erythema using digital photographs. Additionally, skin biophysical parameters (corneometer, TEWL) and global improvement scores for skin texture were assessed. Results The area of total microcrusts was reduced in the study group which applied both serum and cream. The global improvement score of the post‐treatment erythema was significantly reduced. Investigator‐assessed global improvement scores were higher in the combination treatment group. Additionally, there was no adverse event, which was associated with the use of either hUCBMSCs containing serum or cream. Conclusion The application of human cord blood cell containing serum and cream resulted in accelerated wound healing and reduced post‐treatment erythema, which effectively reduced recovery time after ablative laser treatment.

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“…10,11,26 It also promotes the growth of various cells such as squamous epithelium and vascular endothelium, and enables regulation of protein synthesis. 15,28 Epidermal growth factor is a polypeptide that is widely distributed in humans and animals and can regulate multi-cell growth. Early studies have demonstrated the effect of epidermal growth factor on oral ulcers: 29 it can provide anti-inflammatory support, relieve oral pain, increase the patient’s appetite, promote wound healing, minimize the duration and severity of radiation-induced oral mucositis, improve quality of life, and ensure smooth completion of treatment.…”

Section: Discussionmentioning

confidence: 99%

Effects of a compound vitamin B mixture in combination with GeneTime® on radiation-induced oral mucositis

Sun

Zhu

et al. 2019

J Int Med Res

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Objective Both compound vitamin B mixtures and GeneTime® have been used in treatment of oral inflammation. This study aimed to assess the therapeutic effects of a compound vitamin B mixture combined with GeneTime® on radiation-induced oral mucositis. Methods A total of 100 patients with radiation-induced oral mucositis were randomly divided into a control group (vitamin B alone; n = 50 patients) and an observation group (vitamin B plus GeneTime®, n = 50 patients). Clinical outcomes were compared between the two groups for the following 3 weeks. Results The observation group had a significantly greater number of grade 0–I patients and significantly fewer grade II–IV patients than the control group. Among patients in the observation group, a significantly greater number of ulcers healed within 1–2 weeks, compared with those in patients in the control group. Significantly fewer ulcers healed among patients in the observation group at 3 weeks; notably, there were fewer ulcers to heal in the observation group, compared with the control group. Conclusions Use of a compound vitamin B mixture combined with GeneTime® exerted obvious therapeutic effects on radiation-induced oral mucositis and markedly shortened ulcer healing time. Therefore, this strategy may be useful in clinical applications.

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The effects of recombinant human epidermal growth factor containing ointment on wound healing and post inflammatory hyperpigmentation prevention after fractional ablative skin resurfacing: A split‐face randomized controlled study

Abstract: Topical EGF might provide significant wound healing stimulation for chronic wound more than acute wound. Further studies, especially in post laser wound or other cosmetic purposes are needed.

Cited by 28 publications

References 26 publications

Effect of epidermal growth factor ointment on persistent epithelial defects of the cornea

Effect of epidermal growth factor ointment on persistent epithelial defects of the cornea

The effect of human umbilical cord blood–derived mesenchymal stem cell media containing serum on recovery after laser treatment: A double‐blinded, randomized, split‐face controlled study

Effects of a compound vitamin B mixture in combination with GeneTime® on radiation-induced oral mucositis

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