The effects of repeated applications of antimicrobial photodynamic therapy in the treatment of residual periodontal pockets: a systematic review

Franco, T P M; Santos, Ana Paula Pires dos; Canabarro, Antônio

doi:10.1007/s10103-018-02703-2

Cited by 21 publications

(25 citation statements)

References 46 publications

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“…Further benefiting from the noninvasiveness and site-confined irradiation of light or ultrasound, the potential systemic toxicity that frequently troubles conventional antibiotic therapy is promisingly avoided. If needed, the ROS-mediated aPDT/SDT also allows repeated treatments, and this process rarely induces bacterial resistance [17][18][19]. More importantly, it is a great bonus that most of photo/ sonosensitizers possess inherent optical characteristics and 1 3 therefore can be used as imaging probe to optically diagnose bacterial infections.…”

Section: Introductionmentioning

confidence: 99%

Beyond Antibiotics: Photo/Sonodynamic Approaches for Bacterial Theranostics

et al. 2020

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Rapid evolution and propagation of multidrug resistance among bacterial pathogens are outpacing the development of new antibiotics, but antimicrobial photodynamic therapy (aPDT) provides an excellent alternative. This treatment depends on the interaction between light and photoactivated sensitizer to generate reactive oxygen species (ROS), which are highly cytotoxic to induce apoptosis in virtually all microorganisms without resistance concern. When replacing light with low-frequency ultrasonic wave to activate sensitizer, a novel ultrasound-driven treatment emerges as antimicrobial sonodynamic therapy (aSDT). Recent advances in aPDT and aSDT reveal golden opportunities for the management of multidrug resistant bacterial infections, especially in the theranostic application where imaging diagnosis can be accomplished facilely with the inherent optical characteristics of sensitizers, and the generated ROS by aPDT/SDT cause broad-spectrum oxidative damage for sterilization. In this review, we systemically outline the mechanisms, targets, and current progress of aPDT/SDT for bacterial theranostic application. Furthermore, potential limitations and future perspectives are also highlighted.

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Section: Introductionmentioning

confidence: 99%

Beyond Antibiotics: Photo/Sonodynamic Approaches for Bacterial Theranostics

et al. 2020

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“…However, the e®ect of plaque bio¯lm is still controversial. [11][12][13] Hematoporphyrin monomethyl ether (HMME) is a photosensitizer developed in China and¯rst applied to wine stain. This porphyrin has the characteristics of high photoactivity and low toxicity.…”

Section: Introductionmentioning

confidence: 99%

Effect of antibacterial photodynamic therapy on Streptococcus mutans plaque biofilm in vitro

Liang

Zou

et al. 2020

J. Innov. Opt. Health Sci.

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The main objective of this study is to evaluate the antibacterial effect of antibacterial photodynamic therapy (aPDT) on Streptococcus mutans (S. mutans) biofilm model in vitro. The selection of photosensitizers is the key step for the efficacy of photodynamic therapy (PDT). However, no studies have been conducted in the oral field to compare the functional characteristics and application effects of PDT mediated by various photosensitizers. In this research, the antibacterial effect of Methylene blue (MB)/650[Formula: see text]nm laser and Hematoporphyrin monomethyl ether (HMME)/532[Formula: see text]nm laser on S. mutans biofilm was compared under different energy densities to provide experimental reference for the clinical application of the two PDT. The yield of lactic acid was analyzed by Colony forming unit (CFU) and spectrophotometry, and the complete biofilm activity was measured by Confocal Laser Scanning Microscopy (CLSM) to evaluate the bactericidal effect on each group. Based on the results of CFU, the bacterial colonies formed by 30.4[Formula: see text]J/cm2 532[Formula: see text]nm MB-aPDT group and 30.4[Formula: see text]J/cm2 532[Formula: see text]nm HMME-aPDT group were significantly less than those in other groups, and the bacterial colonies in HMME-aPDT group were less than those in HMME-aPDT group. Lactic acid production in all treatment groups except the photosensitizer group was statistically lower than that in the normal saline control group. The activity of bacterial plaque biofilm was significantly decreased in the two groups treated with 30.4[Formula: see text]J/cm2 aPDT. Therefore, aPDT suitable for energy measurement can kill S. mutans plaque biofilm, and MB-aPDT is better than HMME-aPDT.

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“…In the presence of oxygen, reactive oxygen species are produced and cause microbial killing without interfering with the proposed medical treatment. 5 While most aphthous ulcers heal within 1-2 weeks without any treatment, the presence of pain and local infection, especially in immunocompromised patients, requires therapeutic intervention.…”

Section: Discussionmentioning

confidence: 99%

“…Recent literature data showed promising modulatory effects of aPDT on inflammatory mediators, such as cytokines (TNFα, Interleucina1β, and metalloprotein matrix), with probable systemic repercussion. 5 Another point to highlight is that the PBMT protocol, which was maintained between aPDT sessions, is known to produce antiinflammatory, analgesic, and biomodulator effects, leading to pain relief and faster healing. 4 Besides, both aPDT and PBMT showed to be non-invasive, atraumatic, and inexpensive.…”

Section: Discussionmentioning

confidence: 99%