The effects of resveratrol on vasospasm after experimental subarachnoidal hemorrhage in rats

Karaoğlan, Alper; Akdemir, Osman; Barut, Şeref; Köktürk, Sibel; Uzun, Hafize; Taşyürekli, Mustafa; Çolak, Ahmėt

doi:10.1016/j.surneu.2007.07.031

Cited by 33 publications

(26 citation statements)

References 38 publications

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“…20 Several agents against CV have been trialled clinically and in experimental models, including lazaroids (21-aminosteriond tirilazad mesylate); the endothelin antagonists nitric oxide and nitroglycerin; glutamate antagonists; leukocyte adhesion inhibitors; perfluorocarbons; protein kinase inhibitors and others. [21][22][23] Tirilazad mesylate, protein kinase inhibitors (fasudil) and endothelin antagonists seem the agents with the greatest potential to prevent the adverse effects of vasospasm. 22,23 Data are mean ± standard deviation.…”

Section: Discussionmentioning

confidence: 99%

Effects of ebselen versus nimodipine on cerebral vasospasm subsequent to experimental subarachnoid hemorrhage in rats

Gül

Bahadir

Hancı

et al. 2010

Journal of Clinical Neuroscience

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Section: Discussionmentioning

confidence: 99%

Effects of ebselen versus nimodipine on cerebral vasospasm subsequent to experimental subarachnoid hemorrhage in rats

Gül

Bahadir

Hancı

et al. 2010

Journal of Clinical Neuroscience

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“…Resveratrol treatment was shown to decrease the oxidative damage in all these 3 models (Ates et al, 2006; Ates et al, 2007; Karaoglan et al, 2008) The earliest study of oxidative stress after resveratrol treatment in traumatic CNS injury compared methylprednisolone (MP) treatment to resveratrol treatment in a weight-drop model of rat SCI, and showed that resveratrol decreased lipid peroxidation and edema, and increased ultrastructural integrity (Yang and Piao, 2003). This was supported by a subsequent study that showed that resveratrol treatment decreased MDA levels and preserved mitochondrial integrity after spinal cord ischemia in rabbits (Kaplan et al, 2005).…”

Section: Anti-oxidative Effects Of Resveratrolmentioning

confidence: 99%

Resveratrol neuroprotection in stroke and traumatic CNS injury

Lopez

Dempsey

Vemuganti

2015

Neurochemistry International

140

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Resveratrol, a stilbene formed in many plants in response to various stressors, elicits multiple beneficial effects in vertebrates. Particularly, resveratrol was shown to have therapeutic properties in cancer, atherosclerosis and neurodegeneration. Resveratrol-induced benefits are modulated by multiple synergistic pathways that control oxidative stress, inflammation and cell death. Despite the lack of a definitive mechanism, both in vivo and in vitro studies suggest that resveratrol can induce a neuroprotective state when administered acutely or prior to experimental injury to the CNS. In this review, we discuss the neuroprotective potential of resveratrol in stroke, traumatic brain injury and spinal cord injury, with a focus on the molecular pathways responsible for this protection.

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“…Thus, the use of free radical scavengers in animal models of SAH [11,12] and some clinical trials [13,14] have demonstrated beneficial effects of these agents on ischemic neurological deficits due to SAH-induced vasospasms. We have recently shown that melatonin, which is a potent free radical scavenger, reversed SAH-induced histopathological and biochemical alterations [15].…”

Section: Introductionmentioning

confidence: 99%

Alpha Lipoic Acid Alleviates Oxidative Stress and Preserves Blood Brain Permeability in Rats with Subarachnoid Hemorrhage

et al. 2009

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The neuroprotective effect of alpha lipoic acid (ALA; 100 mg/kg, po), a dithiol antioxidant, on experimentally induced subarachnoid hemorrhage (SAH) was assessed in Wistar albino rats. Neurological examination scores recorded at the 48th h of SAH induction were increased in SAH groups, which were accompanied with significant increases in the formation of reactive oxygen species, DNA fragmentation ratios, malondialdehyde levels and myeloperoxidase activity, while significant decreases in the brain glutathione content and Na(+), K(+)-ATPase activity were observed. On the other hand, ALA treatment reversed all these biochemical indices as well as SAH-induced histopathological alterations. Increased brain edema, impaired blood-brain-barrier permeability and neurological scores were also improved by ALA treatment. The results demonstrate that ALA exerts neuroprotective effects via the enhancement of endogenous antioxidant enzyme activity, the inhibition of neutrophil accumulation and free radical generation, suggesting a therapeutic potential in reducing secondary injury after SAH in patients.

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The effects of resveratrol on vasospasm after experimental subarachnoidal hemorrhage in rats

Cited by 33 publications

References 38 publications

Effects of ebselen versus nimodipine on cerebral vasospasm subsequent to experimental subarachnoid hemorrhage in rats

Effects of ebselen versus nimodipine on cerebral vasospasm subsequent to experimental subarachnoid hemorrhage in rats

Resveratrol neuroprotection in stroke and traumatic CNS injury

Alpha Lipoic Acid Alleviates Oxidative Stress and Preserves Blood Brain Permeability in Rats with Subarachnoid Hemorrhage

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