The Effects of Rhein and Honokiol on Metabolic Profiles in a Mouse Model of Acute Pancreatitis

Huang, Wei; Liu, Huan; Yu, Li; Mai, Gang

doi:10.12659/msm.925727

Cited by 6 publications

(10 citation statements)

References 28 publications

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“…Rhein (4,5-dihydroxyanthraquinone-2-carboxylic acid) originates from a wide range of TCM sources, such as rhubarb (Dahuang), Polygonum multiflorum (Heshouwu), Polygonum cuspidatum (Huzhang), and cinnamon (Jue Mingzi). [84] It serves multiple functions in AP and SAP by regulating the JAK2/STAT3 signaling pathway, it not only possesses anti-inflammatory effects, [85,86] and down-regulates TNF-α, NF-κB, and TGF-β but can also induce apoptosis [87] and slows down pancreatic fibrosis. [88] The combination of Rhein and Honokiol can also play a role in the treatment of pancreatitis [86] (Table 3).…”

Section: Rheinmentioning

confidence: 99%

“…The mechanisms by which baicalin treat pancreatitis Name Targets/pathway Property Type of study Reference Baicalin miR-15a, CDC42/MAP3K1/MAP2K4/JNK IL-6, IL-1β, TNF-α Anti-inflammatory Intraperitoneal injection of caerulein (AP) [84] PKD1, NF-κB Anti-inflammatory and antioxidant SAP [85] Bax/Bcl-2 Anti-inflammatory, induce apoptosis Retrograde infusion of 3.5% sodium taurocholate to the pancreatic duct (SAP) [86] TNF-αmRNA, NF-κB Anti-inflammatory Intraperitoneal injection of cerulein (AP) [87] MDA, NO, SOD, SOD1, miR-136-5p, Bax, survivin, Bcl-2, caspase-3, caspase-7…”

Section: Tablementioning

confidence: 99%

“…Retro-pumping 3.0% sodium cholate to the common bile duct (SAP) [73] LC3(B/A), p62, beclin-1 Attenuates autophagy response Inject 3% sodium taurocholate into the biliopancreatic duct (AP) [74] TNF-α, IL-1β Anti-inflammatory and inhibit cell apoptosis AR42J cells were treated with LPS and caerulein for 3 h [75] P2X7/NLRP3, ASC, caspase-1 Attenuates pancreatic ductal cell injury - [76] Bip, PERK, ATF6, IRE1 Reduced calcium overload and inhibit ER stress response - Polygonum cuspidatum (Huzhang), cinnamon (Jue Mingzi). [84] It serves multiple functions in AP and SAP by regulating the JAK2/STAT3 signaling pathway, it not only possesses anti-inflammatory effects, [85,86] and down-regulates TNF-α, NF-κB, and TGF-β but can also induce apoptosis [87] and slows down pancreatic fibrosis. [88] The combination of Rhein and Honokiol can also play a role in the treatment of pancreatitis [86] (Table 3).…”

Section: Inhibit Apoptosis and Improve Intestinal Dysfunctionmentioning

confidence: 99%

“…[84] It serves multiple functions in AP and SAP by regulating the JAK2/STAT3 signaling pathway, it not only possesses anti-inflammatory effects, [85,86] and down-regulates TNF-α, NF-κB, and TGF-β but can also induce apoptosis [87] and slows down pancreatic fibrosis. [88] The combination of Rhein and Honokiol can also play a role in the treatment of pancreatitis [86] (Table 3).…”

Section: Inhibit Apoptosis and Improve Intestinal Dysfunctionmentioning

confidence: 99%

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Natural Chinese herbs for the prevention and treatment of acute pancreatitis: a narrative review

Cui

Zhou

et al. 2022

Journal of Pancreatology

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Acute pancreatitis (AP) is a disease characterized by local inflammation in the pancreas, followed by trypsin activation, and may result from multiple etiologies. Approximately 20% of AP can progress to severe acute pancreatitis (SAP), which can lead to systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndromes (MODS). SAP mortality rates have remained high in recent years, but there are currently no specific drugs designed to reduce these rates. Clinical studies have shown that patients can reduce the symptoms of the disease and slow down the development of the disease after taking the Chinese medicine decoction. Basic studies have shown that in AP or SAP disease models, the use of Chinese medicine monomers can improve the condition of rates. These natural Chinese herbal products can improve pancreatitis, given their ability to act on multiple targets. However, they have not been widely employed clinically and studied sufficiently and thoroughly. Therefore, this review aimed to summarize the pathophysiological mechanisms underlying pancreatitis and review the potential role of natural Chinese herbs (monomers and decoctions) in clinical and basic research.

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Section: Rheinmentioning

confidence: 99%

Section: Tablementioning

confidence: 99%

Section: Inhibit Apoptosis and Improve Intestinal Dysfunctionmentioning

confidence: 99%

Section: Inhibit Apoptosis and Improve Intestinal Dysfunctionmentioning

confidence: 99%

See 2 more Smart Citations

Natural Chinese herbs for the prevention and treatment of acute pancreatitis: a narrative review

Cui

Zhou

et al. 2022

Journal of Pancreatology

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“…Nevertheless, AP and AKI cause distinct disorders in the amino acid metabolic profile [ 13 , 14 ]. Several studies presented that regulating the overall serum metabolome may protect AP [ 15 – 17 ], but very little is known about the effect of regulating the amino acid metabolome in SAP-AKI.…”

Section: Introductionmentioning

confidence: 99%

Zengye Decoction Attenuated Severe Acute Pancreatitis Complicated with Acute Kidney Injury by Modulating the Gut Microbiome and Serum Amino Acid Metabolome

Dai

Yao

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Objective. To explore the effect and underlying mechanism of Zengye decoction (ZYD), a traditional formula from China, on the severe acute pancreatitis (SAP) rat model with acute kidney injury (AKI). Methods. The SAP-AKI model was induced by 3.5% sodium taurocholate. Rats were treated with normal saline or ZYD twice and sacrificed at 36 h after modeling. Amylase, lipase, creatinine, blood urea nitrogen, kidney injury molecule 1(KIM-1), and multiple organs’ pathological examinations were used to assess the protective effect of ZYD. Gut microbiome detected by 16S rRNA sequencing analysis and serum amino acid metabolome analyzed by liquid chromatography-mass spectrometry explained the underlying mechanism. The Spearman correlation analysis presented the relationship between microflora and metabolites. Results. ZYD significantly decreased KIM-1( P < 0.05 ) and the pathological score of the pancreas ( P < 0.05 ), colon ( P < 0.05 ), and kidney ( P < 0.05 ). Meanwhile, ZYD shifted the overall gut microbial structure (β-diversity, ANOSIM R = 0.14, P = 0.025 ) and altered the microbial compositions. Notably, ZYD reduced the potentially pathogenic bacteria—Bacteroidetes, Clostridiales vadin BB60 group, and uncultured_Clostridiales_bacterium, but promoted the short-chain fatty acid (SCFA) producers—Erysipelotrichaceae, Bifidobacterium, Lactobacillus, and Moryella (all P < 0.05 ). Moreover, principal component analysis (PCA), partial least squares-discriminant analysis (PLS-DA), and hierarchical clustering analysis (HCA) presented a remarkable change in amino acid metabolome after SAP-AKI induction and an apparent regulation by ZYD treatment (R2Y 0.878, P = 0.01 ; Q2 0.531, P = 0.01 ). Spearman’s correlation analysis suggested that gut bacteria likely influenced serum metabolites levels (absolute r > 0.4 and FDR P < 0.02 ). Conclusions. ZYD attenuated SAP-AKI by modulating the gut microbiome and serum amino acid metabolome, which may be a promising adjuvant treatment.

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Updated pharmaceutical progress on plant antibiotic rhein and its analogs: Bioactivities, structure–activity relationships and future perspectives

Zhang,

Jiang,

Shang

et al. 2024

Bioorganic & Medicinal Chemistry

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The Effects of Rhein and Honokiol on Metabolic Profiles in a Mouse Model of Acute Pancreatitis

Cited by 6 publications

References 28 publications

Natural Chinese herbs for the prevention and treatment of acute pancreatitis: a narrative review

Natural Chinese herbs for the prevention and treatment of acute pancreatitis: a narrative review

Zengye Decoction Attenuated Severe Acute Pancreatitis Complicated with Acute Kidney Injury by Modulating the Gut Microbiome and Serum Amino Acid Metabolome

Updated pharmaceutical progress on plant antibiotic rhein and its analogs: Bioactivities, structure–activity relationships and future perspectives

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