The Effects of Some Solid Buffering Agents in Aqueous Suspension on Prednisolone**Upjohn Company, Kalamazoo, Mich.

The effect of concurrent administration of antacids on prednisolone absorption [letter]

“…The results obtained by Chulski & Forist (1958) suggested that the absorption of prednisolone might be impaired by magnesium trisilicate if the two drugs were taken together, although their results were obtained under more alkaline conditions than would be expected in vivo. To maximize any effect of the antacid the conditions of the present investigation were made more exacting than those of the usual clinical situation.…”

“…To overcome this side effect, prednisolone is sometimes given together with an antacid. Chulski & Forist (1958) demonstrated that magnesium trisilicate, a constituent of several commercially available antacid preparations, adsorbed prednisolone in vitro. They found that aluminium hydroxide did not, but their results did suggest that in patients taking antacids concurrently, the bioavailability of prednisolone might be diminished.…”

Biowaiver Monographs for Immediate Release Solid OralDosage Forms: Prednisolone

“…In an aqueous medium at 37.5°C, magnesium trisilicate seems to adsorb prednisolone and the presence of magnesium oxide leading to chemical degradation. [71] However, these excipients are not part of any formulation currently on the market in the above-mentioned countries and the clinical relevance of the adsorption has never been demonstrated. By contrast, aluminum hydroxide, calcium carbonate, and magnesium carbonate do not seem to adsorb prednisolone.…”

Effect of Vehicles and Other Active Ingredients on Stability of Hydrocortisone

“…It has been suggested (5)(6)(7)(8) that benzylpenicillenic acid (I) in aqueous solutions is in equilibrium with a thiazoli-…”