The effects of testosterone on the mice pinealocytes: a quantitative study

The numerical density of secretory granules dense-core vesicles (DCV) in the cytoplasm of pinealocytes of the pineal gland was estimated by transmission electron microscopy in male white mice and Wistar rats. The 3-day biorhythm and lunaphase changes in the DCV content in the perikaryon and the processes of pinealocytes, which are manifested significantly in different seasons of the year, are established. The three-day biorhythm in adult male mice in comparison with younger male rats is not expressed uniformly in different phases of the moon. The in-phase manifestation of infradian biorhythms in different species of animals during the year with an unchanged daily photophase indicates the existence of common external synchronizers for mammals of these biorhythms that are not associated with the light/dark cycle.

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Infradian Rhythm of the Content of Secretory Granules in Pinealocyte Cytoplasm in Mice and Rats

Герасимов

Kostyuchenko

Потапов

et al. 2018

Bull Exp Biol Med

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Aging is a deprivation syndrome driven by a germ–soma conflict

Heininger¹

2002

Ageing Research Reviews

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The effects of treatment with melatonin on the ultrastructure of mouse leydig cells: a quantitative study

Redins

Redins²,

Novaes

2002

Braz. J. Biol.

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Both the presence of receptors for gonadal steroids in the pineal gland and in vitro observations of direct action of melatonin upon Leydig cells, inhibiting testosterone secretion, indicate a direct connection between pineal gland and gonadal function. In the present study, we used a transmission electron microscope to analyze the morphologic parameters of Leydig cells from adult Swiss outbred white mice treated with daily subcutaneous injections of 100 micrograms of melatonin (N-acetyl, 5-methoxytryptamine), during 22 consecutive days, compared with sham-control animals which had only received the melatonin vehicle. The melatonin group of mice showed a decrease in nuclear volume and fractional nuclear volume; smooth and rough endoplasmic reticulum; mitochondria; and Golgi complex. Our data also showed an increase in cytoplasmic volume, fractional cytoplasmic volume, and lysosomes in these same animals. The results suggest that melatonin, directly or indirectly, alters the ultrastructure of mouse Leydig cells and possibly influences their secretory activity by inhibiting their capacity to secrete steroids.

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The effects of testosterone on the mice pinealocytes: a quantitative study

Cited by 3 publications

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Infradian Rhythm of the Content of Secretory Granules in Pinealocyte Cytoplasm in Mice and Rats

Infradian Rhythm of the Content of Secretory Granules in Pinealocyte Cytoplasm in Mice and Rats

Aging is a deprivation syndrome driven by a germ–soma conflict

The effects of treatment with melatonin on the ultrastructure of mouse leydig cells: a quantitative study

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