The Effects of Thromboxane A2 Synthetase Inhibitor on Chronic Rejection of Kidney Transplantation

Imanishi, Masaaki; Ikegami, M; Nishioka, Tsukasa; Ishii, Tokumi; Uemura, Tadashi; Kunikata, S; Kanda, Hidenori; Matsuura, Takeshi; Akiyama, Takahiro; Kurita, Takashi

doi:10.5980/jpnjurol1989.81.895

Cited by 2 publications

(3 citation statements)

References 2 publications

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“…Administration of thromboxane A2 synthetase inhibitor called OKY-046, has improved the graft function in chronic kidney rejection. It also decreased proteinuria (Imanishi et al, 1990).…”

Section: Eicosanoids In Renal Transplantationmentioning

confidence: 83%

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The role of eicosanoids in renal diseases – potential therapeutic possibilities

et al. 2018

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Eicosanoids are biologically active molecules that are created in the process of oxidation of arachidonic acid (AA) which is a constituent of the cell membrane phospholipids. Throughout the years it was evidenced by experiments that the lipid and lipid-derived metabolites play an important role in physiological and pathological processes in the kidneys. They are being considered as biomarkers in detecting acute kidney injury, nephrotoxicity, glomerulonephritis and early stages of diabetic nephropathy because of their participation in inflammatory processes and in oxidative stress. They might be also considered as potential novel targets of therapy. However, the role of eicosanoids is still not fully clear and needs to be explored in future studies. In this brief review, studies on the role of eicosanoids in physiological and pathological conditions, e.g. acute kidney injury (AKI) and chronic kidney disease (CKD), and in different renal replacement therapies, including kidney transplantation, are being discussed.

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“…Administration of thromboxane A2 synthetase inhibitor called OKY-046, has improved the graft function in chronic kidney rejection. It also decreased proteinuria (Imanishi et al, 1990).…”

Section: Eicosanoids In Renal Transplantationmentioning

confidence: 83%

“…Epoprostenol may be used in renal replacement therapies either alone or with heparin. (Imanishi et al, 1990) 5 patients with chronic vascular rejection after kidney transplantation Thromboxane A2 synthetase inhibitor, called OKY-046, improved graft function after chronic rejection of kidney.…”

Section: First Author Yearmentioning

confidence: 99%

The role of eicosanoids in renal diseases – potential therapeutic possibilities

et al. 2018

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“…Genetic variations of miRNA genes or polymorphisms have important significance and potential value for identifying high-risk individuals, diagnosing patients early, and using interventions in development and susceptibility of disease. 22 – 24 However, the polymorphisms of miR-492 have not been investigated in case–control studies related to HSCR. A polymorphism of miR-492 may affect migration of embryonic intestinal neural crest cells.…”

Section: Introductionmentioning

confidence: 99%

Association between miR-492 rs2289030 G>C and susceptibility to Hirschsprung disease in southern Chinese children

et al. 2020

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Objective Hirschsprung disease (HSCR) originates from disruption of normal neural crest cell migration, differentiation, and proliferation during the fifth to eighth weeks of gestation. This results in the absence of intestinal ganglion cells in the distal intestinal tract. However, genetic variations affecting embryonic development of intestinal ganglion cells are unclear. Therefore, this study aimed to investigated the potential value of miR-492 rs2289030 G>C as a marker of susceptibility to HSCR Methods In this case–control study in southern Chinese children, we collected samples from 1473 controls and 1470 patients with HSCR. TaqMan genotyping of miR-492 rs2289030 G>C was performed by real-time fluorescent quantitative polymerase chain reaction. Results Multivariate logistic regression analysis showed that there was no significant association between the presence of the miR-492 rs2289030 G>C polymorphism and susceptibility to HSCR by evaluating the values of pooled odds ratios and 95% confidence intervals. Similarly, among different HSCR subtypes, rs2289030 G>C was also not associated with HSCR in hierarchical analysis. Conclusions Our results suggest that the miR-492 rs2289030 G>C polymorphism is not associated with susceptibility to HSCR in southern Chinese children. These results need to be further confirmed by investigating a more diverse ethnic population of patients with HSCR.

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The Effects of Thromboxane A2 Synthetase Inhibitor on Chronic Rejection of Kidney Transplantation

Cited by 2 publications

References 2 publications

The role of eicosanoids in renal diseases – potential therapeutic possibilities

The role of eicosanoids in renal diseases – potential therapeutic possibilities

Association between miR-492 rs2289030 G>C and susceptibility to Hirschsprung disease in southern Chinese children

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