The effects of voluntary complex and regular wheel running exercises on the levels of 8‐oxoguanine DNA glycosylase, semaphorin 3B, H2O2, and apoptosis in the hippocampus of diabetic rats

Fazelzadeh, Mohammad; Afzalpour, Mohammad Esmaeil; Mohammadi, Ziya Fallah; Mohammadi, Hossein Falah

doi:10.1002/brb3.1988

Cited by 5 publications

(2 citation statements)

References 49 publications

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“…In this regard, previous studies have confirmed that exercise training, especially aerobic training raises cell proliferation in the dentate gyrus [ 14 ] and hippocampal plasticity [ 15 ], up-regulates brain-derived neurotrophic factor (BDNF) and neuron growth factor (NGF) and down-regulates the genes associated with oxidative stress [ 12 , 16 ]. Most studies have used running training [ 17 – 19 ] to assess the effect of exercise training on diabetes-induced neurodegenerative diseases, and the protective or offensive role of swimming training in memory performance is not yet clear.…”

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confidence: 99%

Swimming training and Plantago psyllium ameliorate cognitive impairment and glucose tolerance in streptozotocin–nicotinamide-induced type 2 diabetic rats

et al. 2021

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Brain malfunction is common in diabetic patients. On the other hand, a growing body of research points to the beneficial effect of medicinal plants and exercise training on insulin sensitivity and brain function. Therefore, the aim of the present study was to investigate the effect of co-administration of swimming training and Plantago psyllium (mixed with standard pelleted food at a weight ratio of 5%) on learning and memory impairment and glucose tolerance in type 2 diabetic rats. For this purpose, 10 healthy and 40 rats with type 2 diabetes were randomly allocated to five groups: healthy sedentary control group (Con), sedentary diabetic group (D), diabetic group subjected to swimming training (D + Tr), diabetic group receiving P. psyllium (D + Ps), and diabetic group subjected to swimming training and receiving P. psyllium (D + Ps + Tr). Diabetes was induced by a single intraperitoneal injection of nicotinamide (120 mg/kg) and streptozotocin (65 mg/kg) separately with 15 min intervals. Experimental groups were treated with swimming training and P. psyllium independently and simultaneously for 12 weeks. Lipid profile and food intake were measured and also, glucose tolerance was evaluated by glucose area under the curve (AUCg) using an oral glucose tolerance test. Passive avoidance learning (PAL) and memory were evaluated by shuttle box test and cognitive memory was assessed by novel object recognition (NOR) and elevated plus-maze (EPM) tests. Diabetic rats exhibited a significant increase in food intake, lipid profile, and AUCg compared to healthy rats. Step-through latency in the PAL acquisition trial (STL-a) and retention test (STL-r) were significantly lower in diabetic rats than in the control group. In the diabetic group without treatment, time spent in the dark compartment increased compared to the control group in the shuttle box test. Discrimination index and distance traveled reduced in diabetic rats. On the other hand, swimming training and P. psyllium alleviated food intake, lipid profile, and glucose tolerance in diabetic rats. Also, the STL-a, STL-r, discrimination index, and distance travelled in the D + Ps + Tr group were significantly more than the diabetic group. Results showed that 12 weeks of swimming training and receiving P. psyllium improved memory deficit in streptozotocin–nicotinamide-induced type 2 diabetic rats possibly through hypolipidemic and hypoglycemic effects. These results suggest that the administration of swimming training and P. psyllium simultaneously might be an effective intervention for the treatment of diabetes-induced behavioral deficits.

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Section: Introductionmentioning

confidence: 99%

Swimming training and Plantago psyllium ameliorate cognitive impairment and glucose tolerance in streptozotocin–nicotinamide-induced type 2 diabetic rats

et al. 2021

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“…Our data suggests that astrocytes are very likely the main cell type in the brain that are affected by these metabolic alterations that may lead to impaired glutamine synthesis, loss of synaptic proteins and eventually synaptic maladaptation and brain dysfunction. Previous studies conducted in young animals with metabolic disturbances showed that physical activity can improve brain function by reducing oxidative stress and lipid peroxidation 68 – 71 , modulating immune responses and reducing neuroinflammation 68 , 69 , 72 – 75 , and improving insulin signaling and glucose utilization 68 , 75 – 79 . Our study also showed that two months of voluntary wheel running significantly improves learning and memory.…”

Section: Discussionmentioning

confidence: 99%

Peripheral and cognitive benefits of physical exercise in a mouse model of midlife metabolic syndrome

Gaamouch

Lin

Wang

et al. 2022

Sci Rep

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Despite national and international efforts for the prevention of metabolic syndrome and its underlying diseases/disorders, its prevalence is still rising, especially in the middle-aged population. In this study, we explore the effect of high fat diet on the development of metabolic syndrome in middle-aged mice and to evaluate the potential benefits of voluntary physical exercise on the periphery as well as brain cognitive function, and to explore the potential mechanisms. We found that metabolic syndrome developed at middle age significantly impairs cognitive function and the impairment is associated with gene dysregulation in metabolic pathways that are largely affecting astrocytes in the brain. Eight-week voluntary wheel running at a frequency of three times a week, not only improves peripheral glucose control but also significantly improves learning and memory. The improvement of cognitive function is associated with restoration of gene expression involved in energy metabolism in the brain. Our study suggests that voluntary physical exercise is beneficial for metabolic syndrome-induced peripheral as well as cognitive dysfunction and can be recommended as therapeutic intervention for metabolic syndrome and associated diseases.

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