The effects of weight loss surgery on blood rheology in severely obese patients

Wiewióra, Maciej; Piecuch, Jerzy; Glück, Marek; Słowińska-Łożyńska, Ludmiła; Sosada, Krystyn

doi:10.1016/j.soard.2015.01.025

Cited by 16 publications

(10 citation statements)

References 23 publications

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“… 31 32 Elevated BMI is known to induce changes in RBC flexibility, bone marrow adipocyte content, and erythropoietin signalling, all of which may affect RDW. 32 33 Additionally, BMI-associated chronic inflammation has been hypothesised to be a mechanistic link between BMI and RBC health; however, recent studies have detected no significant correlation between RDW and inflammatory markers in obese patients. 28 29 Thus, future studies are needed to explore the mechanism(s) of BMI-induced RBC volume variance.…”

Section: Discussionmentioning

confidence: 99%

Using genetics to detangle the relationships between red cell distribution width and cardiovascular diseases: a unique role for body mass index

et al. 2021

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ObjectiveRed cell distribution width (RDW) is an enigmatic biomarker associated with the presence and severity of multiple cardiovascular diseases (CVDs). It is unclear whether elevated RDW contributes to, results from, or is pleiotropically related to CVDs. We used contemporary genetic techniques to probe for evidence of aetiological associations between RDW, CVDs, and CVD risk factors.MethodsUsing an electronic health record (EHR)-based cohort, we built and deployed a genetic risk score (GRS) for RDW to test for shared genetic architecture between RDW and the cardiovascular phenome. We also created GRSs for common CVDs (coronary artery disease, heart failure, atrial fibrillation, peripheral arterial disease, venous thromboembolism) and CVD risk factors (body mass index (BMI), low-density lipoprotein, high-density lipoprotein, systolic blood pressure, diastolic blood pressure, serum triglycerides, estimated glomerular filtration rate, diabetes mellitus) to test each for association with RDW. Significant GRS associations were further interrogated by two-sample Mendelian randomisation (MR). In a separate EHR-based cohort, RDW values from 1-year pre-gastric bypass surgery and 1–2 years post-gastric bypass surgery were compared.ResultsIn a cohort of 17 937 subjects, there were no significant associations between the RDW GRS and CVDs. Of the CVDs and CVD risk factors, only genetically predicted BMI was associated with RDW. In subsequent analyses, BMI was associated with RDW by multiple MR methods. In subjects undergoing bariatric surgery, RDW decreased postsurgery and followed a linear relationship with BMI change.ConclusionsRDW is unlikely to be aetiologically upstream or downstream of CVDs or CVD risk factors except for BMI. Genetic and clinical association analyses support an aetiological relationship between BMI and RDW.

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Section: Discussionmentioning

confidence: 99%

Using genetics to detangle the relationships between red cell distribution width and cardiovascular diseases: a unique role for body mass index

et al. 2021

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“…An elevated concentration of fibrinogen in plasma generates an abnormal increase in RBC aggregation, changing the rheological behavior of blood. Aggregation and its effect in blood rheology have been related to several diseases [160][161][162], such as inflammation, diabetes [80,163,164], hypertension [165], obesity [166] and coronary syndromes [167][168][169].…”

Section: Hemorheological Pathologies and Emergent Microfluidics Diagn...mentioning

confidence: 99%

Microfluidics Approach to the Mechanical Properties of Red Blood Cell Membrane and Their Effect on Blood Rheology

et al. 2022

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In this article, we describe the general features of red blood cell membranes and their effect on blood flow and blood rheology. We first present a basic description of membranes and move forward to red blood cell membranes’ characteristics and modeling. We later review the specific properties of red blood cells, presenting recent numerical and experimental microfluidics studies that elucidate the effect of the elastic properties of the red blood cell membrane on blood flow and hemorheology. Finally, we describe specific hemorheological pathologies directly related to the mechanical properties of red blood cells and their effect on microcirculation, reviewing microfluidic applications for the diagnosis and treatment of these diseases.

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Section: Hemorheological Pathologies and Emergent Microfluidics Diagn...mentioning

confidence: 99%

Modeling and Simulation of Lipid Membranes

2022

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The effects of weight loss surgery on blood rheology in severely obese patients

Cited by 16 publications

References 23 publications

Using genetics to detangle the relationships between red cell distribution width and cardiovascular diseases: a unique role for body mass index

Using genetics to detangle the relationships between red cell distribution width and cardiovascular diseases: a unique role for body mass index

Microfluidics Approach to the Mechanical Properties of Red Blood Cell Membrane and Their Effect on Blood Rheology

Modeling and Simulation of Lipid Membranes

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