The effects of zinc methionine on reproductive and thyroid hormones in rats with polycystic ovarian syndrome

Torshizi, Faeze Fazel; Chamani, Mohammad; Khodaei, Hamid Reza; Sadeghi, Ali Asghar; Hejazi‬, ‪Seyed Hossein; Heravi, Reza Majidzadeh

doi:10.4103/abr.abr_144_20

Cited by 4 publications

(1 citation statement)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Observational studies are in agreement with this notion, as Zn deficiency was associated with a longer time to achieve pregnancy in women actively planning to conceive [62]. Animal experiments have indicated some positive effects of Zn supplementation on fertility in a rat model of PCOS, but whether these preclinical results can be directly translated to human patients with PCOS remains to be evaluated [63].…”

Section: Discussionmentioning

confidence: 56%

Pronounced Trace Element Variation in Follicular Fluids of Subfertile Women Undergoing Assisted Reproduction

Schmalbrock

Weiss²,

Rijntjes

et al. 2021

Nutrients

View full text Add to dashboard Cite

Female subfertility is a growing concern, especially in view of an increasing prevalence of polycystic ovary syndrome (PCOS). Assisted reproductive technologies (ART) offer a perspective for pregnancy, but the outcome rate is still suboptimal. The trace elements (TE), copper (Cu), selenium (Se), and zinc (Zn) are essential for fertility and development. We hypothesized that TE concentrations are related to oocyte quality and growth and affect pregnancy outcomes in women undergoing ART. Concentrations of TE were measured by total reflection X-ray fluorescence. Extracellular glutathione peroxidase 3 (GPX3) and selenoprotein P (SELENOP) were determined as additional Se biomarkers. Corresponding serum and follicular fluid (FF) samples were available from women with (n = 20) and without (n = 20) PCOS diagnosis undergoing hormone treatment within the ART procedure, respectively, and FF samples were classified into five groups based on morphological assessment. Serum showed higher TE concentrations than FF, and TE levels correlated positively between both matrices. Individual FF from the same women showed surprisingly high variability in TE concentration, and follicles without oocytes displayed the lowest TE concentrations. Both Se biomarkers GPX3 and SELENOP were present in FF and correlated positively to Se concentrations. Some notable relationships were observed between morphokinetic parameters, TE concentrations, and GPX3 activity. A slightly depressed serum Zn concentration was observed in PCOS. Our results indicate a direct relationship between TE in serum and FF, positive correlations between the three Se biomarkers in FF, and high variability between the FF from the same woman with the lowest TE concentrations in the follicles with the poorest quality. The differences observed in relation to PCOS diagnoses appear relatively minor. Collectively, the data support the notion that TE assessment of follicles may contribute to optimal oocyte selection and subsequently influence ART success.

show abstract

Section: Discussionmentioning

confidence: 56%

Pronounced Trace Element Variation in Follicular Fluids of Subfertile Women Undergoing Assisted Reproduction

Schmalbrock

Weiss²,

Rijntjes

et al. 2021

Nutrients

View full text Add to dashboard Cite

show abstract

Resveratrol Improves Follicular Development of PCOS Rats by Regulating the Glycolytic Pathway

Liang

Huang

Liu

et al. 2021

Molecular Nutrition Food Res

View full text Add to dashboard Cite

Scope: Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder that can cause infertility; however, the underlying mechanisms remain ill-defined, and there are no available drugs or strategies for the treatment of PCOS. This study examined the therapeutic effect of resveratrol in a rat model of PCOS. Methods and Results: PCOS is induced in rats by administration of letrozole and a high fat diet to determine whether resveratrol has a protective effect. Oral administration of resveratrol significantly decreased body weight, as well as the serum levels of testosterone and follicle stimulating hormone. Resveratrol improved the estrous cycle by restoring the thickness and number of granular cells. Resveratrol increased the levels of lactate and ATP, decreased pyruvate levels, and restored the glycolytic process, upregulating LDHA, HK2, and PKM2. Resveratrol also upregulated SIRT2, thereby modulating the expression of rate-limiting enzymes of glycolysis. Conclusion: Resveratrol suppressed damage to the ovaries in PCOS rats by restoring glycolytic activity, providing potential targets for the treatment of PCOS.

show abstract

The role of zinc in follicular development

Liao

Yin

et al. 2023

Mol Biol Rep

View full text Add to dashboard Cite

The effects of zinc methionine on reproductive and thyroid hormones in rats with polycystic ovarian syndrome

Cited by 4 publications

References 30 publications

Pronounced Trace Element Variation in Follicular Fluids of Subfertile Women Undergoing Assisted Reproduction

Pronounced Trace Element Variation in Follicular Fluids of Subfertile Women Undergoing Assisted Reproduction

Resveratrol Improves Follicular Development of PCOS Rats by Regulating the Glycolytic Pathway

The role of zinc in follicular development

Contact Info

Product

Resources

About