The effects ofMorinda lucida Benth (Rubiaceae) extract on the gastrointestinal tract of rodents

Olajide, Olumayokun A.; Awe, S. O.; Makinde, J. M.

doi:10.1002/(sici)1099-1573(199809)12:6<439::aid-ptr319>3.0.co;2-p

Cited by 5 publications

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

All‐in‐One Theranostic Platform Based on Hollow Microcapsules for Intragastric‐Targeting Antiulcer Drug Delivery, CT Imaging, and Synergistically Healing Gastric Ulcer

Wang

Xue

et al. 2022

Small

View full text Add to dashboard Cite

Bismuth‐containing therapies are suggested as first‐line and rescue alternatives for gastric ulcer (GU) treatment and Helicobacter pylori eradication. The current treatment strategy is called quadruple therapy and includes proton pump inhibitors, bismuth, and two broad‐band antibiotics. This fact may affect medication compliance, leading to a resistance rate of more than 25% to clarithromycin or metronidazole. To counter this, from the perspective of natural products, an intragastric‐targeting all‐in‐one theranostic platform is established: a drug carrier microcapsule composed of multiple synergistic antiulcer drugs, including bismuth, gallotannin, and antibiotics is obtained (BiG@MCs), and the therapeutic effects of BiG@MCs in rodent models are further evaluated. The results show that the BiG@MCs are spherical with homogeneous particle size (3 ± 0.5 µm) and can be response‐released to the acidic environment of the stomach (pH 2.0–3.0), preventing the premature release of the BiG@MCs in physiological conditions. It is worth noting that the bismuth component can be easily identified by computed tomography and other detection instruments, which provide the possibility for drug tracing. In summary, these results indicate that BiG@MCs provide a versatile intragastric‐targeting drug delivery platform for GU therapeutics.

show abstract

All‐in‐One Theranostic Platform Based on Hollow Microcapsules for Intragastric‐Targeting Antiulcer Drug Delivery, CT Imaging, and Synergistically Healing Gastric Ulcer

Wang

Xue

et al. 2022

Small

View full text Add to dashboard Cite

show abstract

A review on anti-peptic ulcer activities of medicinal plants used in the formulation of Enterica, Dyspepsia and NPK 500 capsules

Kumadoh

Archer

Yeboah

et al. 2021

Heliyon

View full text Add to dashboard Cite

Peptic ulcer disease affects many people globally. With the increasing resistance to some orthodox antibiotics such as Clarithromycin and Metronidazole, it is important that new acceptable, safer and effective therapies are developed to manage this disease. Various herbal medicines have been used traditionally for the remedy of peptic ulcer disease (PUD), however scientific information with regards to their anti-peptic ulcer both in-vivo and invitro as well as clinical studies supporting their use is still inadequate. The Centre for Plant Medicine Research, (CPMR) Mampong-Akuapem, Ghana manufactures three herbal Products namely Enterica, Dyspepsia and NPK 500 capsules which are currently used for the remedy of PUD as a triple therapy at its out-patient clinic with promising effects. The aim of this review is to gather information from literature on the anti-ulcer properties, pharmacological, phytochemical constituents and related activities of herbal plants used at the CPMR for formulation of the triple herbal therapy. This review may, provide some scientific bases for the use of Enterica, Dyspepsia and NPK 500 capsules in the management of Peptic ulcer at the CPMR out-patient clinic. Methods: Organization for the review involved the on and/or offline search for information from available literature using electronic data and scientific research information resources such as PubMed, Science Direct and Google scholar. Results: In this review, fifteen ethno-medicinal plants used for the formulation of Enterica, Dyspepsia and NPK capsules have been discussed, presenting the description of the plants, composition and pharmacological activity. Interpretation: Tables with the summary of reviewed medicinal plants with their anti-ulcer models and inference on possible mechanisms of action were drawn up. The mechanism(s) of action of individual plants and products (Enterica, Dyspepsia and NPK 500 capsules) must be further investigated and established experimentally in-vitro in addition to in-vivo pharmacological and clinical activity studies to confirm their use in the remedy of PUD.

show abstract

Antimicrobials from wild edible plants of Nigeria.

O¹,

Rai²,

Chikindas³

2011

Natural Antimicrobials in Food Safety and Quality

View full text Add to dashboard Cite

This chapter describes the antimicrobial properties of the following wild edible plants (i.e. their extracts and seed oils, among other products) from Nigeria: Alchornea cordifolia, Entada africana, Terminalia avicennioides, Chromolaena odorata, Vernonia species, Anchomanes difformis, Acalypha species, Cassia species, Coula edulis, Lasianthera africana, Morinda lucida, Gongronema latifolium, Tapinanthus dodoneifolius, Diospyros mespiliformis, Heinsia crinata, Funtumia species, Mallotus oppositifolius, Phyllanthus discoideus, Cymbopogon citratus, Garcinia kola, Bridelia ferruginea, Calotropis procera, Parkia species, Gynandropsis gynandra [Cleome gynandra], Mitragyna stipulosa, Leptadenia hastata, Buchholzia coriacea, Massularia acuminata, Landolphia owariensis, Spondias mombin, Paullinia pinnata, Cleome rutidosperma and Tetracarpidium conophorum.

show abstract

The effects ofMorinda lucida Benth (Rubiaceae) extract on the gastrointestinal tract of rodents

Cited by 5 publications

References 9 publications

All‐in‐One Theranostic Platform Based on Hollow Microcapsules for Intragastric‐Targeting Antiulcer Drug Delivery, CT Imaging, and Synergistically Healing Gastric Ulcer

All‐in‐One Theranostic Platform Based on Hollow Microcapsules for Intragastric‐Targeting Antiulcer Drug Delivery, CT Imaging, and Synergistically Healing Gastric Ulcer

A review on anti-peptic ulcer activities of medicinal plants used in the formulation of Enterica, Dyspepsia and NPK 500 capsules

Antimicrobials from wild edible plants of Nigeria.

Contact Info

Product

Resources

About