The efficacy and influence factors analysis of Mifepristone combined with estrogen-progesterone in the treatment of incomplete abortion

Abstract

To analyze the efficacy and influencing factors of Mifepristone combined with estrogen-progesterone sequential therapy (Femoston) in the treatment of incomplete abortion. This retrospective cohort study included 93 patients with incomplete abortion. All patients took 50 mg of Mifepristone 2 times a day for 5 days and then took Femoston once a day (starting with estradiol tablets/2 mg) for 28 days. Without any indication of intrauterine residue by ultrasonic examination was judged to be effective. According to statistical analysis, this study calculated the effective rate and analyzed its influencing factors. A 2-sided value of P < .05 was considered statistically significant. The total response rate of the treatment regimen was 86.67%. body mass index was a significant influencing factor for treatment outcome (OR 0.818, 95% confidence interval 0.668–0.991, P = .041). For patients with incomplete abortion, Mifepristone combined with estrogen-progesterone sequential therapy has a remarkable therapeutic effect. Patients with a lower body mass index may respond much more significantly to this treatment regimen.

Evaluation of different doses of Femoston therapy for incomplete abortion: A prospective observational trial

“…Participants with incomplete abortion were administered 25 mg mifepristone (twice a day) for 14 days on the day of diagnosis based on consensus and previous studies. [24][25][26] Then, the patients were informed of their condition by the 2 doctors in charge and informed the pros and cons of the 3 groups of conservative treatment at the first follow-up, and then were classified into 3 groups according to their willingness. Participants in the femoston (1/10) group were administered 2 tablets of femoston (1/10) (one estradiol tablet and 1 estradiol and dydrogesterone tablet) daily for 14 days with estradiol tablets containing 1 mg of estradiol and estradiol and dydrogesterone tablets containing 1 mg of estradiol and 10 mg of dydrogesterone.…”