The Efficacy of Burow's Solution as an Ear Preparation for the Treatment of Chronic Ear Infections

Kashiwamura, Masaaki; Chida, Eiji; Matsumura, Michiya; Nakamaru, Yuuji; Suda, Noriyuki; Terayama, Yoshihiko; Fukuda, Satoshi

doi:10.1097/00129492-200401000-00002

Cited by 40 publications

(16 citation statements)

References 11 publications

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“…Thorp et al 16 demonstrated a higher effi cacy of Burow's solution compared to an acetic acid solution (1-3%). Kashiwamura et al 17 presented the time-dependent changes of the bactericidal effects of Burow's solution against S. aureus, pneumococci, Candida albicans, and Aspergillus species. For S. aureus, our results demonstrated a stronger antimicrobial effect of Burow's solution than that observed in Kashiwamura's study; shortterm treatment with the solution resulted in the death of all S. aureus bacterial cells.…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial effects of Burow’s solution on Staphylococcus aureus and Pseudomonas aeruginosa

et al. 2012

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Burow's solution has been shown to be effective against chronic suppurative otitis media and otitis externa. We demonstrated that Burow's solution had antibacterial effects against Staphylococcus aureus and Pseudomonas aeruginosa, inducing ultrastructural changes in these bacteria in vitro. S. aureus strain 209P and P. aeruginosa strain IID1130 were treated with 13% Burow's solution. Viable cell counts were determined to measure bactericidal effects. Ultrastructural changes in cells of both strains were examined by scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Viable cell counting revealed that S. aureus cells treated with Burow's solution were killed within 30 min. The viable cell count of P. aeruginosa was reduced by 1 × 10(7) colony-forming units/ml (CFU/ml) after a 60-min treatment. SEM examination of S. aureus revealed blebbing on the surface of bacterial cells, whereas TEM revealed undulating deformation of the bacterial cell wall, diluted cytoplasm, and cell membrane detachment. SEM observations of P. aeruginosa revealed a more apparent undulating deformation of the bacterial cell surface. TEM observations also revealed deformations in the bacterial cell wall and diluted cytoplasm in both bacteria. These findings show that Burow's solution is active against S. aureus and P. aeruginosa, resulting in damage to the cell wall.

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Section: Discussionmentioning

confidence: 99%

Antimicrobial effects of Burow’s solution on Staphylococcus aureus and Pseudomonas aeruginosa

et al. 2012

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“…Burow's solution is a medicine that can be locally administered in otitis externa, granular myringitis, chronic otitis, and post-operative mastoid cavities; it has also been demonstrated to be effective on resistant microorganisms [2,17,18] . Shimizu et al [19] have reported the successful treatment of a patient with malign externa otitis using Burow's solution.…”

Section: Discussionmentioning

confidence: 99%

The Effects of Topical Burow's and Castellani's Solutions on the Middle Ear Mucosa of Rats

Başal¹,

Günel²,

Eryılmaz³

et al. 2016

Int Adv Otol

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OBJECTIVE:The aim of this study is to investigate the early histopathologic effects of Burow's and Castellani's solutions on the middle ear mucosa of rats. MATERIALS and METHODS:The study was conducted with 26 Wistar albino female rats. Gelfoam that was soaked in 4% Burow's solution was inserted into the middle ears of the rats in the Burow group (n=10); over 2 weeks, 0.1 mL Burow's solution was administered once a day through perforation into the middle ear. The same procedure was applied to the rats in the Castellani group (n=10) using classical Castellani's solution and to the rats in the control group (n=6) using physiological saline solution. At day 1 after the last administration, all groups were decapitated; their bullas were dissected. The bullas were histopathologically evaluated and graded with respect to increase in leukocytes with polymorphic nuclei, mononuclear cell infiltration, and fibrosis. The data obtained were statistically analyzed. RESULTS:In the Burow group, the fibrosis scores were significantly higher than those in the control group (p=0.039), the scores of leukocytes with polymorphic nuclei were significantly higher than those in the control group (p=0.034), and the total scores were significantly higher than those in the control group (p=0.022). CONCLUSION:We suggest Castellani's solution as a safe alternative in the treatment of otomycosis and external otitis in the presence of tympanic membrane perforation. However, because of the inflammatory changes it causes in the middle ear mucosa, we do not recommend the use of Burow's solution in the presence of tympanic membrane perforation.

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“…Mittels der sog. Burow L ö sung (13 % Aluminium Acetat in Wasser) beschriebenen Arznei konnten erfolgreich MRSA bedingte Otorrhoen in bis zu 80 % der F ä lle saniert werden [24,25] . Essigs ä ureohrentropfen werden insbesondere von Tauchern [25] unterschiedlich 14 70 % + Vancomycin Tropfen [27] 10 Tage 35 90 % + Wirkstoff ototoxisch Gentamicin Tropfen [27] 10 Tage 20 20 % + Wirkstoff ototoxisch Ofl oxacin [15] 1 -4 × / Woche f ü r 2 -3 Wochen 20 20 % ± Mupirocin Salbe [15] 1 -4 × / Woche f ü r 2 -3 Wochen 16 100 % + Fucidin Tropfen [31] 2 Wochen 1 100 % + L ö sungsstoff e ototoxisch Chloramphenicol Tropfen [33] 5 -7 Tage 3 100 % + Tobramycin Tropfen [33] 5 -7 Tage 3 100 % + Wirkstoff ototoxisch moxazol Amp.)…”

Section: Untersuchungsbefund ▼unclassified

Die Behandlung des MRSA besiedelten Mittelohres; eine Fallbeschreibung und Literaturübersicht

Senska¹,

Rüsing²

2010

Laryngo-Rhino-Otol

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The Efficacy of Burow's Solution as an Ear Preparation for the Treatment of Chronic Ear Infections

Abstract: Burow's solution was considered to be an effective otologic preparation.

Cited by 40 publications

References 11 publications

Antimicrobial effects of Burow’s solution on Staphylococcus aureus and Pseudomonas aeruginosa

Antimicrobial effects of Burow’s solution on Staphylococcus aureus and Pseudomonas aeruginosa

The Effects of Topical Burow's and Castellani's Solutions on the Middle Ear Mucosa of Rats

Die Behandlung des MRSA besiedelten Mittelohres; eine Fallbeschreibung und Literaturübersicht

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