The efficacy of computer-based cognitive training for executive dysfunction in schizophrenia

Mak, Monika; Tyburski, Ernest; Starkowska, Anna; Karabanowicz, Ewa; Samochowiec, Agnieszka; Samochowiec, Jerzy

doi:10.1016/j.psychres.2019.06.041

Cited by 18 publications

(9 citation statements)

References 67 publications

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“…Cognitive deficit is the key feature of schizophrenia (SCZ), and includes a range of domain deficits such as executive function, learning, memory, attention, and social cognition. [1][2][3][4] These may emerge long before illness onset and remain unchanged with improvement of clinical symptoms in SCZ patients. 5 Cognitive impairments are correlated with poor clinical outcome and rehabilitation of social function.…”

Section: Introductionmentioning

confidence: 99%

<p>Increased Plasma Kynurenic Acid Levels are Associated with Impaired Attention/Vigilance and Social Cognition in Patients with Schizophrenia</p>

Huang

Ding

et al. 2020

NDT

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Preclinical studies have reported that abnormal kynurenic acid (KYNA) may play a role in cognitive deficits. Schizophrenia (SCZ) is characterized by a wide range of cognitive deficits that may evolve from abnormal KYNA. This study aimed to explore the relationship between KYNA and cognitive impairment in SCZ, which has not yet been reported. Methods: We recruited 30 SCZ patients and 34 healthy controls, measured clinical symptoms by using the Positive and Negative Syndrome Scale and performed cognitive tests using the MATRICS Consensus Cognitive Battery (MCCB). Plasma levels of tryptophan, kynurenine, and KYNA were determined by high-performance liquid chromatography-tandem mass spectrometry. Results: We found that plasma KYNA levels were significantly higher in patients than in healthy controls (p=0.009). The cognitive performance of patients in the total MCCB scores and the scores of all subscales were significantly lower than those in healthy controls (all P < 0.01). Correlation analysis showed that KYNA levels were negatively correlated with attention/vigilance (r=-0.457, p=0.019) and social cognition (r=-0.481, p=0.013) only in SCZ patients. Conclusion: Our results indicate that elevated plasma KYNA levels may serve as a biomarker of cognitive impairment in SCZ patients.

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Section: Introductionmentioning

confidence: 99%

<p>Increased Plasma Kynurenic Acid Levels are Associated with Impaired Attention/Vigilance and Social Cognition in Patients with Schizophrenia</p>

Huang

Ding

et al. 2020

NDT

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“…Further fNIRS research is needed to evaluate other cognitive tests such as Wisconsin Card Sorting Test and working memory task (e.g., N-back), which may be helpful in differentiating people with schizophrenia and healthy controls ( 67 ). fNIRS can be an objective tool to assess changes in brain hemodynamics after computer-based cognitive training in addition to improvement of scores in neuropsychological tests ( 68 ). A meta-analysis found that second generation antipsychotics such as clozapine, olanzapine, quetiapine, and risperidone produce a mild remediation of cognitive deficits in schizophrenia ( 69 ).…”

Section: Discussionmentioning

confidence: 99%

Differentiating people with schizophrenia from healthy controls in a developing Country: An evaluation of portable functional near infrared spectroscopy (fNIRS) as an adjunct diagnostic tool

et al. 2023

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IntroductionThis study aimed to evaluate portable functional near-infrared spectroscopy (fNIRS) device as an adjunct diagnostic tool in Vietnam to assess hemodynamics when people with schizophrenia and healthy controls performed cognitive tasks.MethodsOne hundred fifty-seven participants were divided into schizophrenia (n = 110) and healthy controls group (n = 47), which were recruited by match of age, and gender. Hemodynamic responses in the frontal cortex were monitored with a 48-channel portable device during the Stroop Color-Word Test (SCWT) and Verbal Fluency Test (VFT). General linear model compared the differences in oxyhemoglobin (HbO2) levels between the two groups. The Receiver Operating Characteristic (ROC) graph was generated for each neuroanatomical area.ResultsPeople with schizophrenia did not show significant activation in the frontal lobe during the SCWT and VFT as compared to pre-task. During the VFT, the area under the ROC curve of the bilateral dorsolateral prefrontal cortex, bilateral orbitofrontal cortex, bilateral frontopolar prefrontal cortex, and bilateral ventrolateral prefrontal cortex were greater than 0.7 (p < 0.001). The area under the ROC curve (AUC) for the right orbitofrontal cortex was maximal during the VFT (AUC = 0.802, 95%CI = 0.731–0.872). The Youden’s index reached a peak (0.57) at the optimal cut-point value (HbO2 cutoff <0.209 μmol/ml for schizophrenia) in which the sensitivity was 85%; specificity was 72%; positive predictive value (PPV) was 0.88; negative predictive value (NPV) was 0.68 and correct classification rate was 76%.DiscussionAssessing hemodynamics during VFT by portable fNIRS offers the potential as an adjunct diagnostic tool for schizophrenia in developing countries.

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“…One such promising method is cognitive remediation (CR). CR is an intervention based on behavioral training composed of various tasks focused on improving cognitive functioning ( 47 , 48 ). It is an evidenced-based intervention in schizophrenia which can improve cognitive functioning and, with it, the quality of everyday functioning ( 47 ).…”

Section: Possibilities For Treatmentmentioning

confidence: 99%

Neurocognition and Social Cognition— Possibilities for Diagnosis and Treatment in Ultra-High Risk for Psychosis State

et al. 2021

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In recent decades, clinicians have developed the construct of ultra-high risk (UHR) for psychosis to characterize the prodromal phase of psychosis or classify people with weakly expressed psychotic symptoms. In this conceptual analysis, we have gathered up-to-date data about the clinical picture of neurocognition and social cognition in people at UHR for psychosis. We also discuss treatment options. A well-chosen therapeutic approach can help to deal with difficulties and delay or even prevent the development of full-blown psychotic disorders in the UHR group. Despite much evidence supporting the benefits of therapy, early interventions are still not as widely used as they should be. Thus, a better understanding of the UHR state is very important for all healthcare workers.

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The efficacy of computer-based cognitive training for executive dysfunction in schizophrenia

Cited by 18 publications

References 67 publications

<p>Increased Plasma Kynurenic Acid Levels are Associated with Impaired Attention/Vigilance and Social Cognition in Patients with Schizophrenia</p>

<p>Increased Plasma Kynurenic Acid Levels are Associated with Impaired Attention/Vigilance and Social Cognition in Patients with Schizophrenia</p>

Differentiating people with schizophrenia from healthy controls in a developing Country: An evaluation of portable functional near infrared spectroscopy (fNIRS) as an adjunct diagnostic tool

Neurocognition and Social Cognition— Possibilities for Diagnosis and Treatment in Ultra-High Risk for Psychosis State

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