The efficacy of manual therapy (Chuna) for chronic obstructive pulmonary disease

Roh, Ji-ae; Park, Jihye; Lee, Beom-Joon; Jung, Hee-Jae

doi:10.1097/md.0000000000018832

Cited by 3 publications

(6 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The protocol for this SR was registered in the international prospective register of SRs [ 36 ] with the identifier CRD42019141150. The review process was pre-specified in a published protocol to prevent reporting and researcher bias [ 37 ]. All steps were performed independently by two researchers, and discrepancies were resolved by another researcher.…”

Section: Methodsmentioning

confidence: 99%

“…The risk of bias consists of the following five domains: (1) bias arising from the randomization process, (2) bias due to deviations from the intended interventions, (3) bias due to missing outcome data, (4) bias in the measurement of the outcome, and (5) bias in the selection of the reported result. These five evaluation domains differed from the seven domains stated in our protocol [ 37 ].…”

Section: Methodsmentioning

confidence: 99%

“…In addition to the previously described protocol [ 37 ], we further attempted to analyze the RCTs according to their research designs in this review. The analysis protocol was divided into four categories, as follows:…”

Section: Methodsmentioning

confidence: 99%

“…Electronic searches and other sources. This study was performed based on a previously described method [37]. Searches were conducted independently in online electronic databases, including MEDLINE via PubMed, EMBASE, the Cochrane Central Register of Controlled Trials (CENTRAL), and the China National Knowledge Infrastructure database, to retrieve research relevant to the use of MT in COPD.…”

Section: Database and Search Strategiesmentioning

confidence: 99%

“…Search strategy. The method used in this study has been previously described [37]. Articles were searched using Related Medical Subject Heading terms and synonyms in various combinations in each database from inception through January 31, 2021, without language restrictions.…”

Section: Database and Search Strategiesmentioning

confidence: 99%

See 4 more Smart Citations

The efficacy of manual therapy for chronic obstructive pulmonary disease: A systematic review

2021

Self Cite

View full text Add to dashboard Cite

Background Manual therapy (MT) can be beneficial in the management of chronic obstructive pulmonary disease (COPD). However, evidence of the efficacy of MT for COPD is not clear. Therefore, we aimed to review the effects of MT, including Chuna, in people diagnosed with COPD. Methods MEDLINE via PubMed, EMBASE, The Cochrane Central Register of Controlled Trials (CENTRAL), China National Knowledge Database (CNKI), KoreaMed, Korean Medical Database (KMbase), and Oriental Medicine Advanced Searching Integrated System (OASIS) were searched. Randomized controlled trials (RCTs) and crossover RCTs were included. The main inclusion criteria were COPD diagnosis (forced expiratory volume in the first second [FEV1]/forced vital capacity [FVC] < 0.70). The primary outcomes were lung function and exercise capacity. The secondary outcomes were symptoms, quality of life (QoL), and adverse event (AE)s. Studies reporting one or both of the primary outcomes were included. The Cochrane RoB 2.0 tool was used to assess the risk of bias. Data synthesis and analysis were conducted according to the trial design. Results Of the 2564 searched articles, 13 studies were included. For the primary outcomes, the effect of MT on pulmonary function and exercise capacity in COPD was partly significant but could not be confirmed due to the limited number of studies included in the subgroups. For the secondary outcomes, no definitive evidence regarding the improvement of symptoms and QoL was found, and some minor adverse effects were reported. Conclusions There is insufficient evidence to support the role of MT in the management of COPD. High-quality studies are needed to thoroughly evaluate the effect of MT on COPD.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Database and Search Strategiesmentioning

confidence: 99%

Section: Database and Search Strategiesmentioning

confidence: 99%

See 3 more Smart Citations

The efficacy of manual therapy for chronic obstructive pulmonary disease: A systematic review

2021

Self Cite

View full text Add to dashboard Cite

show abstract

Release and Actions of Inflammatory Exosomes in Pulmonary Emphysema: Potential Therapeutic Target of Acupuncture

Zou¹,

Bhat²,

Yuan³

et al. 2021

JIR

View full text Add to dashboard Cite

Background: Exosomes have been reported to mediate activation of the inflammatory response by secretion of inflammasome products such as IL-1β or IL-18 and that changes in exosomes production or secretion may be a therapeutic target for treatment of a variety of different chronic diseases. The present study tested the hypothesis that exosome-mediated release of NLRP3 inflammasome products instigates the inflammatory response in the lung during emphysema, a type of chronic obstructive pulmonary disease (COPD) and that electroacupuncture (EA) may attenuate emphysema by inhibition of NLRP3 inflammasome activation and consequent inflammation. Methods: The COPD mice model was developed by injecting porcine pancreatic elastase (PPE) via puncture tracheotomy and instillation. EA (4 Hz/20 Hz, 1 to 3 mA) was applied to the bilateral BL13 and ST36 for 30 min, once every other day for 2 weeks. Micro computed tomography (micro-CT) was performed to measure lung function. Histopathological changes in the lungs were displayed by HE staining. Results: In a mouse model of porcine pancreatic elastase (PPE)-induced emphysema, the lung tissue was found to display several key features of emphysema, including alveolar septal thickening, enlarged alveoli, interstitial edema, and inflammatory cells infiltration. Lungs of mice receiving PPE exhibited substantially increased low attenuation area (LAA) in micro-CT images. The colocalization of NLRP3 vs ASC or caspase-1 detected by confocal microscopy was shown to increase in both bronchial and alveolar walls, indicating the increased formation of NLRP3 inflammasomes. IL-1β, a prototype NLRP3 inflammasome activating product, was also found to have increased in the lung during emphysema, which was colocalized with CD63 (an exosome marker), an indicative of inflammatory exosome formation. By nanoparticle tracking analysis (NTA), IL-1β-containing exosomes were shown to significantly increase in the bronchoalveolar lavage (BAL) from mice with emphysema. Therapeutically, IL-1β production in the lung during emphysema was significantly reduced by EA at the acupoint Feishu (BL13) and Zusanli (ST36), accompanied by decreased colocalization of NLRP3 vs ASC or caspase-1. Increased exosome release into BAL during emphysema was shown to be significantly attenuated in EA-treated mice compared to their controls. However, EA of non-specific BL23 together with ST36 acupoint had no effects on NLRP3 inflammasome activation, exosome release and associated lung pathology during emphysema. Conclusion: NLRP3 inflammasome activation in concert with increased release of exosomes containing IL-1β or other inflammasome products contributes to the development of lung inflammation and injury during PPE-induced emphysema and that EA of lung-specific acupoints attenuates inflammasome activation and exosome release, thereby reducing inflammatory response in the lung of mice with emphysema.

show abstract

The effectiveness of current COPD management protocols in public hospitals in China

Wei

2023

IJRSM

View full text Add to dashboard Cite

Chronic Obstructive Pulmonary Disease (COPD) remains a pressing global health concern, necessitating comprehensive understanding and improved management strategies. This study aimed to elucidate current COPD management practices and perceptions among healthcare professionals and patients across select geographic regions. Through a cross-sectional design, qualitative data was collected and analyzed, revealing both challenges and strengths in current COPD care approaches. Key findings suggest that while there is a general consensus on the importance of a multidisciplinary approach, gaps in training, knowledge dissemination, and collaboration persist. Additionally, the study underscores the need for integrating objective clinical measures alongside qualitative feedback to holistically evaluate patient outcomes and care efficacy. The results provide a pivotal foundation upon which healthcare systems can build, emphasizing the integration of technology, personalized patient-centered care, and enhanced multidisciplinary collaboration. This study not only highlights the current landscape of COPD management but also indicates clear avenues for future research and intervention, aiming for global betterment in COPD care.

show abstract

The efficacy of manual therapy (Chuna) for chronic obstructive pulmonary disease

Abstract: Supplemental Digital Content is available in the text

Cited by 3 publications

References 21 publications

The efficacy of manual therapy for chronic obstructive pulmonary disease: A systematic review

The efficacy of manual therapy for chronic obstructive pulmonary disease: A systematic review

Release and Actions of Inflammatory Exosomes in Pulmonary Emphysema: Potential Therapeutic Target of Acupuncture

The effectiveness of current COPD management protocols in public hospitals in China

Contact Info

Product

Resources

About