The efficient hemostatic effect of Antarctic krill chitosan is related to its hydration property

Wu, Shuai; Huang, Zhengdong; Yue, Jianhui; Liu, Di; Wang, Ting; Ezanno, Pierre; Ruan, Changshun; Zhao, Xiaoli; Lu, Wenqiang; Pan, Haobo

doi:10.1016/j.carbpol.2015.06.030

Cited by 48 publications

(16 citation statements)

References 53 publications

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“…Antarctic krill ( Euphausia superba ) is the predominant prey in the Southern Ocean owing to its rich biomass (Auerswald, Meyer, Teschke, Hagen, & Kawaguchi, ; Wu et al., ), and 70% of which are distributed between longitudes 0° and 90°W (Atkinson et al., ). It comprises 77.9%–83.1% moisture, 11.9%–15.4% protein, 0.4%–3.6% lipids, and approximately 2% chitin (Grantham, ).…”

Section: Introductionmentioning

confidence: 99%

The comparison of krill oil extracted through ethanol–hexane method and subcritical method

Sun

Shi

Xue

et al. 2019

Food Science & Nutrition

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This study aimed to develop a safe method EH (ethanol–hexane) to extract two kinds of krill oil (KO) simultaneously and analyze their composition. Meanwhile, subcritical butane and subcritical butane‐dimethyl ether extraction were used to extract KO for analysis comparison. Folch method was used to extract total lipids. When the volume ratio of ethanol to hexane is 4:6, the separation effect of ethanol layer and hexane layer is best. At this condition, the EH method yielded similar amount of lipids (up to 97. 72% of total lipids) with subcritical butane extraction method (97.60%). The recovery rate of ethanol and hexane was 83.6% and 86.86%, respectively. KO in hexane layer and extracted by the subcritical butane method are abundant in astaxanthin (910 and 940 mg/kg respectively), while KO in the ethanol layer had the highest phospholipid (PL) content (47.34%), n−3 polyunsaturated fatty acids (PUFA) content (45.51%), and the lowest fluorine content (11.17 μg/g), making it a potential candidate in the nutraceutical and antioxidant industry.

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Section: Introductionmentioning

confidence: 99%

The comparison of krill oil extracted through ethanol–hexane method and subcritical method

Sun

Shi

Xue

et al. 2019

Food Science & Nutrition

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show abstract

“…This phenomenon could be caused by the combined effects of multiple clotting routes of chitosan and HA. Indeed, chitosan stimulated platelet and erythrocytes aggregation via its amino residue (positively charged surface) [19] and concentrated blood to accelerate clotting via its hydration behavior [20], showing completely different coagulation routes to HA. On the other hand, when HA was coated onto chitosan matrix, the clotting activity was not only depending on the combined effects of chitosan and HA, but also influenced by the amount of blood concentrated by porous scaffold.…”

Section: Resultsmentioning

confidence: 99%

Hydroxyapatite: a promising hemostatic component in orthopaedic applications

Yin¹,

Zhou²,

Ni³

et al. 2017

Biol Eng Med

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Agent with both great blood clotting activity and bone regeneration ability is deserved to replace conventional bone wax. Recently, hydroxyapatite (HA) has attracted interests from researchers with its both hemostatic and bone healing functions. In present work, the blood clotting activity comparisons of HA to other potential bone repairing materials including calcium silicate, calcium combined attapulgite, calcium tripolyphosphate, and chitosan were carried out to show HA as a recommended hemostatic component to replace bone wax. In addition, the impacts of HA synthesis routes on its blood clotting activity were evaluated, indicating increase of surface area as well as active Ca 2+ of HA can greatly enhance blood clotting. With these attributes, it is expected HA can be a promising component in fabricating hemostatic materials in orthopedic applications as alternatives to bone wax.

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“…In these cases, the body's natural mechanisms are not sufficient to control massive bleeding. Therefore, hemostatic intervention is commonly required (Wu et al, ). Current standard hemostatic treatments often rely on compression wraps or gauze.…”

Section: Discussionmentioning

confidence: 99%

In situ forming gelatin/hyaluronic acid hydrogel for tissue sealing and hemostasis

Luo

Liu

et al. 2019

J Biomed Mater Res

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Fibrin glue has been widely used as a surgical sealing and hemostatic agent. Its application is restricted due to poor tissue adhesion and low mechanical strength. To develop better tissue sealant and hemostatic agent, this study prepared the injectable hydrogels by chemically cross‐linking gelatin (G) with or without hyaluronic acid (HA) in situ at a mild condition. The rheological analysis, Fourier transform infrared spectroscopy, swelling, proteolytic degradation, biocompatibility, tissue sealing, and hemostatic ability of the hydrogels were investigated. It was found that the chemical cross‐linking rapidly formed in both self‐crosslinking gelatin (sc‐G) and gelatin/hyaluronate acid (G/HA) hydrogels. The hydrogels could be degraded by trypsin and had a desirable biocompatibility. The tissue sealing ability of the hydrogels was superior to fibrin glue. Furthermore, the G/HA hydrogel had similar hemostatic performance as fibrin glue, and was better than that of gelatin hydrogel. The results in the study indicated that the G/HA hydrogel could be used in clinic as a tissue sealant or surgical hemostat.

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The efficient hemostatic effect of Antarctic krill chitosan is related to its hydration property

Cited by 48 publications

References 53 publications

The comparison of krill oil extracted through ethanol–hexane method and subcritical method

The comparison of krill oil extracted through ethanol–hexane method and subcritical method

Hydroxyapatite: a promising hemostatic component in orthopaedic applications

In situ forming gelatin/hyaluronic acid hydrogel for tissue sealing and hemostasis

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