The elastase and melanogenesis inhibitory and anti-inflammatory activities of phosvitin phosphopeptides produced using high-temperature and mild-pressure (HTMP) pretreatment and enzyme hydrolysis combinations

Lee, Jieun; An, Bong-Jeun; Jo, Cheorun; Min, Byungrok; Paik, Hyun‐Dong; Ahn, Dong U.

doi:10.1016/j.psj.2023.102680

Cited by 8 publications

(3 citation statements)

References 39 publications

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“…Yap et al (2020) reported that the monophenolase and diphenolase activity inhibition values of EWPPs were 45.9% and 48.1%, respectively, at the optimized conditions (55% trypsin, 45% chymotrypsin, S/E 10:1 w/w, 2 h; 100% trypsin, S/E 22.13:1 w/w and 3.18 h), and EWPPs were able to bind to H85, H94, H259, H263, and H296 (hotspots for active residues) as well as F92, M280, and F292 (stabilizing residues) of tyrosinase based on the structure-activity relationship analysis [128]. PPPs prepared with HTMP-T-S (HTMP pretreatment-trypsin-sterilization hydrolysis) showed the most potent inhibition of tyrosinase and elastase, with the inhibition rates of 88.09% and 70.67% in sequence, respectively, which reduced the melanin content in B16F10 melanoma cells [82].…”

Section: Enzyme Inhibitorsmentioning

confidence: 99%

Preparation, Biological Activities, and Potential Applications of Hen Egg-Derived Peptides: A Review

Song,

Chen,

Liu

et al. 2024

Foods

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Food-derived peptides have been extensively studied for their benefits in humans. Hen eggs, characterized by high protein and digestibility, are an excellent source of food-derived bioactive peptides. This review summarizes the preparation methods, purification, and identification of hen egg-derived peptides (HEPs). The preparation methods mainly include enzymatic hydrolysis, microbial fermentation, and chemical synthesis. Genetic engineering is an emerging trend of HEP preparation. Then, we summarize the biological activities of HEPs, such as antioxidant activities, enzyme inhibitory activity, and antibacterial activity, of which the enzyme inhibitory activity is comprehensively summarized for the first time. The structure–activity relationship and underlying mechanism of the HEPs are further elucidated. Finally, the applications, future challenges, and opportunities of HEPs were mainly discussed in the food and non-food sectors. We focus on the potential applications of HEPs in intestinal health and assembly delivery and provide a reference for the further utilization and commercial development of HEPs.

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Section: Enzyme Inhibitorsmentioning

confidence: 99%

Preparation, Biological Activities, and Potential Applications of Hen Egg-Derived Peptides: A Review

Song,

Chen,

Liu

et al. 2024

Foods

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“…Similarly, some peptides harbor the ability to forestall damages orchestrated by reactive nitrogen species (RNS), encompassing peroxynitrite and nitric oxide, the latter recognized as the most potent oxidant [ 117 ]. It is imperative to note that ROS/RNS have garnered infamy as culprits behind a gamut of chronic ailments, spanning diabetes, renal impairment, Parkinson’s disease, cardiovascular events, and an array of inflammatory disorders, skin aging, cancers, cardiovascular maladies, osteoporosis, and gastrointestinal afflictions [ 118 , 119 ]. The vista that unfolds before us beckons toward the horizon of bioactive peptides as therapeutic forerunners.…”

Section: The Implications Of Research On Bioactive Peptides and Gut M...mentioning

confidence: 99%

Effect of Bioactive Peptides on Gut Microbiota and Their Relations to Human Health

Wijesekara,

Abeyrathne,

Ahn

2024

Foods

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Bioactive peptides derived from both exogenous and endogenous origins have been studied extensively to use their beneficial effects in humans and animals. Bioactive peptides exhibit beneficial bodily functions and contribute to a healthy gastrointestinal system by influencing barrier functions, immune responses, and gut microbiota. Gut microbiota is a diverse microbial community that significantly influences the overall well-being and homeostasis of the body. Factors such as diet, age, lifestyle, medication, and environmental circumstances can affect the composition and diversity of the gut microbiota. The disturbances or imbalances in the gut microbiota have been associated with various health problems. The interplays between bioactive peptides and gut microbiota are not fully understood, but bioactive peptides hold promise as modulators of the gut microbiota to promote gut health. Almost all the bioactive research on human health, including the development of therapeutics and nutritional interventions, uses cell culture, even though their direct biofunctional activities can only occur when absorbed in the intestine and into the blood system. This review focuses on the current understanding of bioactive peptides in gut microbiota and their impact and mechanisms on gut and human health. The novelty of this review lies in its comprehensive analysis of the multifaceted interactions between bioactive peptides and gut microbiota, integrating knowledge from diverse disciplines between microbiology and nutrition. By elucidating the underlying mechanisms and identifying current research gaps, this review offers an outlook on the potential of bioactive peptides in promoting gut health and shaping future therapeutic and nutritional interventions.

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“…In a model of H 2 O 2 -induced Caco-2 cells, PPPs could upregulate the expression of antioxidant genes and promote the secretion of antioxidant enzymes, reducing oxidative stress and protecting cells from oxidative damage [114−115] . Lee et al [116] found that PPP obtained by enzymatic hydrolysis (trypsin) after high temperature and light pressure pretreatment had the efficacy of reducing elastase and tyrosinase activities in B16F10 melanoma cells. In addition, melanin levels in melanoma cells decreased from 31.18% to 38.58% after the intervention of PPP.…”

Section: Enhancement Of Bone Density and Antioxidant Effect Of Pvmentioning

confidence: 99%

Eggstraordinary health: exploring avian egg proteins and peptides in boosting immunity and health maintenance

Li,

Xia,

Zeng

et al. 2023

Food Science of Animal Products

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Amidst the outbreak of the Corona Virus Disease 2019 , there has been a pivotal shift in nutritional focus towards adopting healthier lifestyles to enhance immune function. The successive resurgence of COVID-19 serves as a stark reminder that prioritizing the enhancement of our own immune systems is of paramount importance. Eggs are nutritious, productive, cost-effective, and affordable for consumption. Likewise, eggs are exclusive among the numerous ways consumers can obtain high-quality animal protein.Egg proteins and their peptide derivatives are abundant and biologically active and have significant therapeutic effects on chronic diseases induced by a variety of factors, including metabolic syndrome, making eggs an important raw material for the study of proteins and peptide-active substances. This paper reviewed methods for the isolation and purification of avian egg proteins and their derived peptides; the effects of the proteins and peptides in enhancing the body's immunity, lowering blood pressure and expression levels of inflammatory factors; as well as the potential of the proteins and peptides in reducing the risk of chronic diseases such as osteoporosis and cardiovascular disease. This review was written with the expectation that it would provide a comprehensive understanding of the potential value of poultry egg proteins for maintaining health.

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The elastase and melanogenesis inhibitory and anti-inflammatory activities of phosvitin phosphopeptides produced using high-temperature and mild-pressure (HTMP) pretreatment and enzyme hydrolysis combinations

Cited by 8 publications

References 39 publications

Preparation, Biological Activities, and Potential Applications of Hen Egg-Derived Peptides: A Review

Preparation, Biological Activities, and Potential Applications of Hen Egg-Derived Peptides: A Review

Effect of Bioactive Peptides on Gut Microbiota and Their Relations to Human Health

Eggstraordinary health: exploring avian egg proteins and peptides in boosting immunity and health maintenance

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