The Electrocardiogram in Chronic Thiamine Deficiency in Rats

Proposed Diagnostic Criteria for the Brugada Syndrome

“…Right or left bundle branch block, left ventricular hypertrophy 28 Acute myocardial ischemia or infarction 29 Acute myocarditis 30 Right ventricular ischemia or infarction 31 Dissecting aortic aneurysm 32 Acute pulmonary thromboemboli 33 Various central and autonomic nervous system abnormalities 34,35 Heterocyclic antidepressant overdose 36 Duchenne muscular dystrophy 37 Friedreich's ataxia 38 Thiamine deficiency 39,40 Hypercalcemia 41 Hyperkalemia 42 Cocaine intoxication 43,44 Mediastinal tumor compressing RVOT 45 Arrhythmogenic right ventricular dysplasia/cardiomyopathy 24,25 Long-QT syndrome, type 3 11,12 Other conditions that can lead to ST-segment elevation in the right precordial leads…”

ST-segment Elevation of Electrocardiogram in a Patient with Shoshin Beriberi

“…Shoshin beriberi is the fulminant form of this disease and is characterized by hypotension, tachycardia, and lactic acidosis (1)(2)(3)(4)(5)(6). While thiamine deficiency is also associated with ST-segment elevation in some animal models (7,8), there has been no report of ST-segment elevation in humans with beriberi. We describe a case of Shoshin beriberi and ST-segment elevation, which was subsequently resolved with thiamine therapy.…”

The Effects of Thiamine Deprivation, and Oxythiamine- And Pyrithiamine-Treatment on Cardiac Function and Metabolism in the Rat

“…DRURY et al (29) found no change in the ECG of thiamine-deprived or pair-fed rats until a moribund condition resulted. HUNDLEY et al (31) found prolonged P-R interval in 7 out of 20 acutely thiamine-deficient rats. YosHITosHI et al (32) reported a 17.6% occurrence of arrhythmia in severely deficient rats.…”