The Emerging and Diverse Roles of Src‐Like Adaptor Proteins in Health and Disease

Marton, Nikolett; Baricza, Eszter; Érsek, Barbara; Buzás, Edit I.; Nagy, György

doi:10.1155/2015/952536

Cited by 13 publications

(16 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Of the 22 positional candidate genes identified in the 47 identified QTL, 10 were identified as potential functional candidate genes based upon their gene ontology results and previous reports on their function in the literature (Bannantine and Bermudez, 2013;Liu et al, 2013;Marton et al, 2015). Some of these genes are novel in the sense that they have not previously been associated with bovine paratuberculosis.…”

Section: Candidate Genes Associated With Humoral Response To Mapmentioning

confidence: 99%

“…The src-like adaptor protein 2 (SLAP-2), encoded by SLA2, has been observed to be expressed in the small intestine, colon, spleen, and lymph nodes in humans (Fagerberg et al, 2014). As reviewed by Marton et al (2015), SLAP-2 negatively regulates the antigen receptor signaling action of both B and T lymphocytes, thus suppressing host immune responses. It has also been suggested that SLAP-2 is necessary for the maturation and activation of mono-Journal of Dairy Science Vol.…”

Section: Zbtb20mentioning

confidence: 99%

See 1 more Smart Citation

Candidate genes associated with the heritable humoral response to Mycobacterium avium ssp. paratuberculosis in dairy cows have factors in common with gastrointestinal diseases in humans

McGovern

Purfield

Ring

et al. 2019

Journal of Dairy Science

View full text Add to dashboard Cite

Infection of cattle with bovine paratuberculosis (i.e., Johne's disease) is caused by Mycobacterium avium ssp. paratuberculosis (MAP) and results in a chronic incurable gastroenteritis. This disease, which has economic ramifications for the cattle industry, is increasing in detected prevalence globally; subclinically infected animals can silently shed the bacterium into the environment for years, exposing contemporaries and hampering disease-control programs. The objective of the present study was to first quantify the genetic parameters for humoral response to MAP in dairy cattle. This was followed by a genome-based association analysis and subsequent downstream bioinformatic analyses from imputed whole genome sequence SNP data. After edits, ELISA test records were available on 136,767 cows; analyses were also undertaken on a subset of 33,818 of these animals from herds with at least 5 MAP ELISApositive cows, with at least 1 of those positive cows being homebred. Variance components were estimated using univariate animal and sire linear mixed models. The heritability calculated from the animal model for humoral response to MAP using alternative phenotype definitions varied from 0.02 (standard error = 0.003) to 0.05 (standard error = 0.008). The genome-based associations were undertaken within a mixed model framework using weighted deregressed estimated breeding values as a dependent variable on 1,883 phenotyped animals that were ≥87.5% Holstein-Friesian. Putative susceptibility quantitative trait loci (QTL) were identified on Bos taurus autosome 1,

show abstract

Section: Candidate Genes Associated With Humoral Response To Mapmentioning

confidence: 99%

Section: Zbtb20mentioning

confidence: 99%

Candidate genes associated with the heritable humoral response to Mycobacterium avium ssp. paratuberculosis in dairy cows have factors in common with gastrointestinal diseases in humans

McGovern

Purfield

Ring

et al. 2019

Journal of Dairy Science

View full text Add to dashboard Cite

show abstract

“…A previous study demonstrated that the migration activity of murine fibroblast cells in Src-knockout rats is reduced, which further supports the role of Src in cell migration (22). The interactions between Src, the extracellular matrix and integrin are essential for the induction of ras homolog gene family, member A (RhoA), and in turn, the activation of RhoA is closely associated with cell migration (23). The present study revealed that mechanical stress significantly suppressed Src protein expression in OLF cells.…”

Section: Discussionmentioning

confidence: 58%

Mechanical stress affects the osteogenic differentiation of human ligamentum flavum cells via the BMP-Smad1 signaling pathway

Yan

2017

Molecular Medicine Reports

View full text Add to dashboard Cite

The aim of the present study was to investigate the effects of mechanical stress on the osteogenic differentiation of human ligamentum flavum cells via the bone morphogenetic protein (BMP)‑Smad1 signaling pathway. Mechanical stress increased cell proliferation and induced osteogenic differentiation of human cells derived from the ossification of the ligamentum flavum (OLF). In addition, mechanical stress activated osteocalcin (OC), alkaline phosphatase (ALP) and runt‑related transcription factor 2 (RUNX‑2) mRNA expression, and suppressed Ets proto‑oncogene 1 (Ets‑1) and sex determining region Y‑box 2 (SOX‑2) mRNA expression in OLF cells. Src protein expression was suppressed by mechanical stress in human OLF cells. In addition, the protein expression levels of BMP, phosphorylated (p)‑mothers against decapentaplegic homolog‑1 (Smad1) and p‑p38‑mitogen‑activated protein kinases (p38MAPK) were increased by mechanical stress. These results demonstrate that mechanical stress effectively increases cell proliferation, promotes the osteogenic differentiation rate of OLF cells, activates OC, ALP and RUNX‑2, and suppresses Ets‑1 and SOX‑2 potentially via the BMP‑Smad1 and Src‑p38MAPK signaling pathways.

show abstract

“…SLA 2 is known to be involved with signal transduction in B and T cells. Further, SLA 2 downregulates humoral and cell-mediated immune responses, by contributing to a correct lymphocytes’ activation and proliferation [73,123,124]. SLA 2 antagonistic effect on lymphocytes proliferation would suggest its putative involvement in opposing the diffusion of T. parva parva in the organism.…”

Section: Discussionmentioning

confidence: 99%

Combining landscape genomics and ecological modelling to investigate local adaptation of indigenous Ugandan cattle to East Coast fever

Vajana

Barbato

Colli

et al. 2018

Preprint

View full text Add to dashboard Cite

63East Coast fever (ECF) is a fatal sickness affecting cattle populations of eastern, central, 64and southern Africa. The disease is transmitted by the tick Rhipicephalus appendiculatus, and 65 caused by the protozoan Theileria parva parva, which invades host lymphocytes and promotes 66 their clonal expansion. Importantly, indigenous cattle show tolerance to infection in ECF-67 endemically stable areas. Here, the putative genetic bases underlying ECF-tolerance were 68 investigated using molecular data and epidemiological information from 823 indigenous cattle 69 from Uganda. Vector distribution and host infection risk were estimated over the study area and 70 subsequently tested as triggers of local adaptation by means of landscape genomics analysis. We 71 identified 41 and seven candidate adaptive loci for tick resistance and infection tolerance, 72 respectively. Among the genes associated with the candidate adaptive loci are PRKG1 and SLA2. 73 PRKG1 was already described as associated with tick resistance in indigenous South African 74 cattle, due to its role into inflammatory response. SLA2 is part of the regulatory pathways 75 involved into lymphocytes' proliferation. Additionally, local ancestry analysis suggested the 76 zebuine origin of the genomic region candidate for tick resistance. 77 Author summary 78The tick-borne parasite Theileria parva parva infects cattle populations of eastern, central 79 and southern Africa, by causing a highly fatal pathology called "East Coast fever". The disease is 80 especially severe for the exotic breeds imported to Africa, as well as outside the endemic areas of 81 East Africa. In these regions, indigenous cattle populations can survive to infection, and this 82 5 tolerance might result from unique adaptations evolved to fight the disease. We investigated this 83 hypothesis by using a method named "landscape genomics", with which we compared the genetic 84 characteristics of indigenous Ugandan cattle coming from areas at different infection risk, and 85 located genomic sites potentially attributable to tolerance. In particular, the method pinpointed 86 two genes, one (PRKG1) involved into inflammatory response and potentially affecting East 87Coast fever vector attachment, the other (SLA2) involved into lymphocytes proliferation, a 88 process activated by T. parva parva infection. Our findings can orientate future research on the 89 genetic basis of East Coast fever-tolerance, and derive from a general method that can be applied 90 to investigate adaptation in analogous host-vector-parasite systems. Characterization of the 91 genetic factors underlying East Coast-fever-tolerance represents an essential step towards 92 enhancing sustainability and productivity of local agroecosystems. 93

show abstract

The Emerging and Diverse Roles of Src‐Like Adaptor Proteins in Health and Disease

Cited by 13 publications

References 51 publications

Candidate genes associated with the heritable humoral response to Mycobacterium avium ssp. paratuberculosis in dairy cows have factors in common with gastrointestinal diseases in humans

Candidate genes associated with the heritable humoral response to Mycobacterium avium ssp. paratuberculosis in dairy cows have factors in common with gastrointestinal diseases in humans

Mechanical stress affects the osteogenic differentiation of human ligamentum flavum cells via the BMP-Smad1 signaling pathway

Combining landscape genomics and ecological modelling to investigate local adaptation of indigenous Ugandan cattle to East Coast fever

Contact Info

Product

Resources

About