The Emerging Evidence for a Protective Role of Fucoidan from Laminaria japonica in Chronic Kidney Disease-Triggered Cognitive Dysfunction

Ma, Zhihui; Yang, Zhiyou; Feng, Xinyue; Deng, Jiahang; He, Chuantong; Li, Rui; Zhao, Yuntao; Ge, Yue‐Wei; Zhang, Yongping; Song, Cai; Zhong, Saiyi

doi:10.3390/md20040258

Cited by 15 publications

(5 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Fucoidans have shown potential bioactivities, including antioxidant, anti-coagulant, anti-tumor, anti-inflammatory, and management of metabolic diseases and kidney dysfunction [ 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 ] with furtherly formulated in pharmaceutical preparations as an essential step for clinical investigations and commercial marketing [ 20 ]. However, the recent studies found that the antioxidant activity is correlated potentially with the phenolic contents in crude fucoidan extracts [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Characterization and Cytotoxic Activity of Microwave-Assisted Extracted Crude Fucoidans from Different Brown Seaweeds

et al. 2023

View full text Add to dashboard Cite

Microwave-assisted extraction (MAE) is recognized as a green method for extraction of natural products. The current research aimed to explore the MAE for fucoidans extraction from different brown seaweeds, including Fucus vesiculosus, F. spiralis, and Laminaria saccharina. Following several solvent-extraction pre-treatment steps and MAE optimization, the algal biomasses were extracted in a ratio of 1:25 in 0.1 M HCl containing 2 M CaCl2 for 1.0 min. The results showed that L. saccharina’s extract was different from the others, regarding the highest sugar content reached 0.47 mg glucose equivalent/mg extract being confirmed by monosaccharide composition analysis and the lowest fucoidan content and sulfation degree at 0.09 mg/mg extract and 0.13, respectively. Moreover, these findings were confirmed by tentative structural elucidation based on Fourier-transform infrared spectrometry which also showed a different spectrum. However, the MAE enhanced melanoidins formation in products, which was confirmed by the intense band at 1420 cm−1. Interestingly, the results of monomeric composition showed that fucoidan extract by MAE from F. vesiculosus belonged to sulfated galactofucans which are known for their potential bioactivities. Furthermore, the cytotoxic activity of the four fucoidans in concentrations ranging from 4.9 µg/mL to 2500 µg/mL was investigated and correlated with the chemical characterization showing that F. vesiculosus_MAE fucoidan was the most potent and safest. The current research revealed the chemical heterogeneity of fucoidans regarding taxonomical class and used greener extraction method of fucoidans toward the achievement of the UN sustainability goals.

show abstract

Section: Introductionmentioning

confidence: 99%

Characterization and Cytotoxic Activity of Microwave-Assisted Extracted Crude Fucoidans from Different Brown Seaweeds

et al. 2023

View full text Add to dashboard Cite

show abstract

“…In the studies of CKD, fucoidan has been reported to improve the composition of gut microbiota. , However, there are few reports on the effect of fucoidan on gut microbiota in DN. Herein, we evaluated the effects of fucoidan on intestinal microflora composition in the early stage of DN (Figure ).…”

Section: Discussionmentioning

confidence: 99%

Fucoidan Improves Early Stage Diabetic Nephropathy via the Gut Microbiota–Mitochondria Axis in High-Fat Diet-Induced Diabetic Mice

Zhong,

Zhang,

Wei

et al. 2024

J. Agric. Food Chem.

View full text Add to dashboard Cite

Diabetic nephropathy (DN) is a common microvascular complication of diabetes. Fucoidan, a polysaccharide containing fucose and sulfate group, ameliorates DN. However, the underlying mechanism has not been fully understood. This study aimed to explore the effects and mechanism of fucoidan on DN in high-fat diet-induced diabetic mice. A total of 90 C57BL/6J mice were randomly assigned to six groups (n = 15) as follows: normal control (NC), diabetes mellitus (DM), metformin (MTF), lowdose fucoidan (LFC), medium-dose fucoidan (MFC), and high-dose fucoidan (HFC). A technique based on fluorescein isothiocyanate (FITC-sinistin) elimination kinetics measured percutaneously was applied to determine the glomerular filtration rate (GFR). After 24 weeks, the mice were sacrificed and an early stage DN model was confirmed by GFR hyperfiltration, elevated urinary creatinine, normal urinary albumin, tubulointerstitial fibrosis, and glomerular hypertrophy. Fucoidan significantly improved the GFR hyperfiltration and renal fibrosis. An enriched SCFAs-producing bacteria and increased acetic concentration in cecum contents were found in fucoidan groups, as well as increased renal ATP levels and improved mitochondrial dysfunction. The renal inflammation and fibrosis were ameliorated through inhibiting the MAPKs pathway. In conclusion, fucoidan improved early stage DN targeting the microbiota−mitochondria axis by ameliorating mitochondrial oxidative stress and inhibiting the MAPKs pathway.

show abstract

“…Moreover, the behavioural changes might be related to changes in hippocampal BDNF and GFAP expression, which are common in renal dysfunction (Ma et al., 2022 ; Mazumder et al., 2019 ). BDNF decrease and GFAP increase could be related to the inflammatory and oxidative changes occurring in hippocampus, as well as urinary Zn losses (Kida et al., 2015 ; Lima Giacobbo et al., 2019 ).…”

Section: Discussionmentioning

confidence: 99%

Possible protective effect of zinc administration on renal and cognitive changes occurring in uninephrectomized adult male Wistar rats

Basta

Yassin

Sayed

2022

Experimental Physiology

View full text Add to dashboard Cite

New Findings What is the central question of this study?Are renal changes occurring post‐nephrectomy accompanied by cognitive changes, and does early administration of zinc supplements such as ZnSO4 to uninephrectomized rats ameliorate the renal and cognitive changes if present? What is the main finding and its importance?Uninephrectomy‐induced renal changes were accompanied by species‐atypical behaviour in rats in both Morris water maze and T maze tests, together with hypozincaemia and hippocampal inflammatory and oxidative changes. Early zinc administration to uninephrectomized rats ameliorated the renal, behavioural, hippocampal and serum zinc changes. Abstract Cognitive impairment is increasingly recognized as an important consequence of kidney disease in humans. Kidney donation is a safe procedure but is known to increase the long‐term risk of cardiovascular and kidney disease. Whether kidney donation impairs cognitive function is not known. In the present study, we examined whether the renal changes occurring post‐nephrectomy were accompanied by cognitive changes as well, and whether early administration of zinc supplements such as ZnSO4 to uninephrectomized (UNX) rats could ameliorate the renal and cognitive changes if present. The present study included 30 adult male Wistar rats that were randomly assigned to three groups (n = 10 per group): sham‐operated rats, UNX and UNX treated with ZnSO4 for 20 weeks. Before termination, rats were subjected to 24‐h urine collection and behavioural testing with the Morris water maze and T maze tests. UNX induced significant proteinuria, renal functional, fibrotic and oxidative changes, as well as increased renal desmin expression. UNX rats also showed significant behavioural changes indicating spatial learning and memory affection, together with decreased hippocampal brain derived neurotrophic factor (BDNF) and antioxidant capacity, and increased glial fibrillary acidic protein (GFAP), nitric oxide and malondialdehyde. In addition, UNX induced significant hyperglycaemia and dyslipidaemia, as well as significant reduction in serum zinc, copper and selenium. Early administration of ZnSO4 starting 1 week post‐nephrectomy significantly ameliorated renal and behavioural changes, as well as hippocampal oxidative, BDNF and GFAP changes. Additionally, Zn recovered serum changes of triglycerides, cholesterol, zinc and copper. Therefore, early administration of zinc to humans undergoing nephrectomy may be of benefit and should be considered in human trials.

show abstract

The Emerging Evidence for a Protective Role of Fucoidan from Laminaria japonica in Chronic Kidney Disease-Triggered Cognitive Dysfunction

Cited by 15 publications

References 63 publications

Characterization and Cytotoxic Activity of Microwave-Assisted Extracted Crude Fucoidans from Different Brown Seaweeds

Characterization and Cytotoxic Activity of Microwave-Assisted Extracted Crude Fucoidans from Different Brown Seaweeds

Fucoidan Improves Early Stage Diabetic Nephropathy via the Gut Microbiota–Mitochondria Axis in High-Fat Diet-Induced Diabetic Mice

Possible protective effect of zinc administration on renal and cognitive changes occurring in uninephrectomized adult male Wistar rats

Contact Info

Product

Resources

About