The emerging functions and roles of circular RNAs in cancer

Qu, Shibin; Liu, Zhengcai; Yang, Xisheng; Zhou, Jingyu; Yu, Heng-Chao; Zhang, Rui; Li, Haimin

doi:10.1016/j.canlet.2017.11.022

Cited by 239 publications

(196 citation statements)

References 90 publications

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“…Lü investigated that the expression level of circ_103110, circ_104689 and circ_104821 were up-regulated in breast cancer tissues while those of circ_006054, circ_100219 and circ_406697 were down-regulated [21]. With the constant breakthrough and application of new technologies such as chip technology and second-generation sequencing, circular RNA has gradually become the focus of tumor genomics research [22].…”

Section: Introductionmentioning

confidence: 99%

Circular RNA Expression Profiling Identifies Prostate Cancer- Specific circRNAs in Prostate Cancer

Xia

Ding

Zhang

et al. 2018

Cell Physiol Biochem

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Background/Aims: Prostate cancer (PCa) is one of the main cancers that damage males’ health severely with high morbidity and mortality, but there is still no ideal molecular marker for the diagnosis and prognosis of prostate cancer. Methods: To determine whether the differentially expressed circRNAs in prostate cancer can serve as novel biomarkers for prostate cancer diagnosis, we screened differentially expressed circRNAs using SBC-ceRNA array in 4 pairs of prostate tumor and paracancerous tissues. A circRNA-miRNA-mRNA regulatory network for the differential circRNAs and their host genes was constructed by Cytoscape3.5.1 software. Quantitative real-time polymerase chain reaction analysis (qRT-PCR) was performed to confirm the microarray data. Results: We found 1021 differentially expressed circRNAs in PCa tumor using SBC-ceRNA array and confirmed the expression of circ_0057558, circ_0062019 and SLC19A1 in PCa cell lines and tumor tissues through qRT-PCR analysis. We demonstrated that combination of PSA level and two differentially expressed circRNAs showed significantly increased AUC, sensitivity and specificity (0.938, 84.5% and 90.9%, respectively) than PSA alone (AUC of serum PSA was 0.854). Moreover, circ_0057558 was correlated positively with total cholesterol. The functional network of circRNA-miRNA-mRNA analysis showed that circ_0057558 and circ_0034467 regulated miR-6884, and circ_0062019 and circ_0060325 regulated miR-5008. Conclusion: Our results demonstrated that differentially expressed circRNAs (circ_0062019 and circ_0057558) and host gene SLC19A1 of circ_0062019 could be used as potential novel biomarkers for prostate cancer.

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Section: Introductionmentioning

confidence: 99%

Circular RNA Expression Profiling Identifies Prostate Cancer- Specific circRNAs in Prostate Cancer

Xia

Ding

Zhang

et al. 2018

Cell Physiol Biochem

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“…Several studies showed that circRNAs act as miRNA sponges . In this study, our analysis identified miR‐760 as a downstream hsa_circ_0007874 target.…”

Section: Discussionmentioning

confidence: 62%

Upregulation of hsa_circ_0007874 suppresses the progression of ovarian cancer by regulating the miR‐760/SOCS3 pathway

Yu²,

Zhang

et al. 2020

Cancer Medicine

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Ovarian cancer (OVA) is a fatal and common malignancy in women worldwide. Circular RNAs (circRNAs) consist of a family of circular endogenous RNAs generated by selective splicing, and they are involved in many diseases. Previous studies reported that hsa_circ_0007874 is aberrantly expressed in cancer and functions in tumorigenesis. While the hsa_circ_0007874 role in OVA is unclear. Here, we detected the hsa_circ_0007874 expression in OVA cell lines using Rt‐qPCR. Hsa_circ_0007874 subcellular localization was confirmed by fluorescence in situ hybridization. The relationship between hsa_circ_0007874, microRNAs (miRNAs), and relative protein levels was assessed using the luciferase reporter assays. Results verified that hsa_circ_0007874 is downregulated in OVA cell lines. hsa_circ_0007874 overexpression decreased the OVA cell migration and proliferation in vitro and in vivo. Bioinformatics and luciferase reporter assays confirmed that miR‐760 and SOCS3 are the downstream targets of hsa_circ_0007874. Downregulation of SOCS3 or miR‐760 overexpression restored the migration and proliferation ability of SKOV3 or A2780 cells overexpressing hsa_circ_0007874. Downregulation of SOCS3 restored the proliferation and migration in miR‐760 knockdown SKOV3 and A2780 cells. In summary, the data suggest that hsa_circ_0007874 acts as a tumor suppressor by regulating the miR‐760/SOCS3 axis, highlighting its potential as an effective therapeutic target for OVA.

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“…They are characterized by the distinct loop structures without 5′ caps and 3′ tails compared to mRNAs . Due to the application of next‐generation sequencing and bioinformatics, circRNAs were now discovered to be widely expressed in cells, exceeding the abundance of the linear mRNAs . circRNAs have now become a new star in RNA research field, as recent reports revealed their critical roles in various biological processes .…”

Section: Discussionmentioning

confidence: 99%

Decreased expression of hsa_circ_0137287 predicts aggressive clinicopathologic characteristics in papillary thyroid carcinoma

Lan

Cao

et al. 2018

Clinical Laboratory Analysis

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The emerging functions and roles of circular RNAs in cancer

Cited by 239 publications

References 90 publications

Circular RNA Expression Profiling Identifies Prostate Cancer- Specific circRNAs in Prostate Cancer

Circular RNA Expression Profiling Identifies Prostate Cancer- Specific circRNAs in Prostate Cancer

Upregulation of hsa_circ_0007874 suppresses the progression of ovarian cancer by regulating the miR‐760/SOCS3 pathway

Decreased expression of hsa_circ_0137287 predicts aggressive clinicopathologic characteristics in papillary thyroid carcinoma

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