The Emerging Proteomic Research Facilitates in-Depth Understanding of the Biology of Honeybees

Altaye, Solomon Zewdu; Meng, Lifeng; Lu, Yuanan; Li, Jianke

doi:10.3390/ijms20174252

Cited by 10 publications

(9 citation statements)

References 106 publications

(199 reference statements)

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“…Furthermore, proteomics has also become a powerful tool for revealing the HGs morphology and physiology that supports honey bee biology (Altaye et al, 2019b;Hu et al, 2019). Notably, the potential of secreting RJ in the HGs of ITBs and RJBs is varied.…”

Section: Molecular Insight Into the Development And Physiology Of Hgsmentioning

confidence: 99%

Novel Insight Into the Development and Function of Hypopharyngeal Glands in Honey Bees

Ahmad

Khan

et al. 2021

Front. Physiol.

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Hypopharyngeal glands (HGs) are the most important organ of hymenopterans which play critical roles for the insect physiology. In honey bees, HGs are paired structures located bilaterally in the head, in front of the brain between compound eyes. Each gland is composed of thousands of secretory units connecting to secretory duct in worker bees. To better understand the recent progress made in understanding the structure and function of these glands, we here review the ontogeny of HGs, and the factors affecting the morphology, physiology, and molecular basis of the functionality of the glands. We also review the morphogenesis of HGs in the pupal and adult stages, and the secretory role of the glands across the ages for the first time. Furthermore, recent transcriptome, proteome, and phosphoproteome analyses have elucidated the potential mechanisms driving the HGs development and functionality. This adds a comprehensive novel knowledge of the development and physiology of HGs in honey bees over time, which may be helpful for future research investigations.

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Section: Molecular Insight Into the Development And Physiology Of Hgsmentioning

confidence: 99%

Novel Insight Into the Development and Function of Hypopharyngeal Glands in Honey Bees

Ahmad

Khan

et al. 2021

Front. Physiol.

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“…Significant progress has been made recently in understanding of the various aspects of the honeybee biology due to the advances in instrumentation and computational analysis utilized in proteomics studies [50]. For example, using two‐dimensional gel electrophoresis (2DE), 3‐glucose oxidase, 1‐peroxiredoxin, and 1‐glutathione‐S‐transferase were identified in the RJ samples of Italian bees (ITBs, or A. m. lingustica ), high RJ‐yielding strain of bees (RJBs), and A. m. carnica bees (Carnica) [44].…”

Section: Proteinaceous Content Of Rjmentioning

confidence: 99%

“…The complexity of the RJ proteome is further increased by the abundant post‐translational modifications (PTMs) of the RJ proteins [50]. For example, analysis of the RJ proteome by a combination of liquid chromatography‐tandem mass spectrometry techniques, N‐glycopeptide enrichment strategies, and bioinformatics identified 25 N‐glycosylated proteins carrying 53 N‐glycosylation sites [54].…”

Section: Proteinaceous Content Of Rjmentioning

confidence: 99%

Multifunctionality and intrinsic disorder of royal jelly proteome

et al. 2021

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Royal Jelly (RJ) is a gelatinous white‐yellowish fluid, possessing a sour taste and a slight phenolic smell that is secreted by the hypopharyngeal and mandibular salivary glands of the nurse honeybees, and is used in nutrition of larvae and adult queens. Similar to other substances associated with the activities of honeybees, RJ not only contains nutritive components, such as carbohydrates, proteins, peptides, lipids, vitamins, and mineral salts, but also represents a natural ingredient with cosmetic and health‐promoting properties. RJ is characterized by remarkable multifunctionality, possessing numerous biological activities. Although this multifunctionality of RJ can be considered as a consequence of its complex nature, many proteins and peptides in RJ are polyfunctional entities themselves. In this article, we show that RJ proteins contain different levels of intrinsic disorder, have sites of post‐translational modifications, can be found in multiple isoforms, and many of them possess disorder‐based binding sites, suggesting that the conformational ensembles of the RJ proteins might undergo change as a result of their interaction with specific binding partners. All these observations suggest that the multifunctionality of proteins and peptides from RJ is determined by their structural heterogeneity and polymorphism, and serve as an illustration of the protein structure‐function continuum concept.

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“…At present RJBs have the potential to produce more than 10 kg RJ/colony/year, which is 10 times more than for non-selected Italian bees [15][16][17][18]. Notably, China is the largest producer and exporter of RJ around the world, producing more than 4000 tons annually, with more than $2.5 billion market, which is 90% of the total RJ production globally and mostly exported to Japan, Europe, and the United States [12,19].…”

Section: Introductionmentioning

confidence: 99%

New Insights into the Biological and Pharmaceutical Properties of Royal Jelly

Ahmad

Campos

Fratini

et al. 2020

IJMS

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169

134

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Royal jelly (RJ) is a yellowish-white and acidic secretion of hypopharyngeal and mandibular glands of nurse bees used to feed young worker larvae during the first three days and the entire life of queen bees. RJ is one of the most appreciated and valued natural product which has been mainly used in traditional medicines, health foods, and cosmetics for a long time in different parts of the world. It is also the most studied bee product, aimed at unravelling its bioactivities, such as antimicrobial, antioxidant, anti-aging, immunomodulatory, and general tonic action against laboratory animals, microbial organisms, farm animals, and clinical trials. It is commonly used to supplement various diseases, including cancer, diabetes, cardiovascular, and Alzheimer’s disease. Here, we highlight the recent research advances on the main bioactive compounds of RJ, such as proteins, peptides, fatty acids, and phenolics, for a comprehensive understanding of the biochemistry, biological, and pharmaceutical responses to human health promotion and life benefits. This is potentially important to gain novel insight into the biological and pharmaceutical properties of RJ.

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The Emerging Proteomic Research Facilitates in-Depth Understanding of the Biology of Honeybees

Cited by 10 publications

References 106 publications

Novel Insight Into the Development and Function of Hypopharyngeal Glands in Honey Bees

Novel Insight Into the Development and Function of Hypopharyngeal Glands in Honey Bees

Multifunctionality and intrinsic disorder of royal jelly proteome

New Insights into the Biological and Pharmaceutical Properties of Royal Jelly

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