2023
DOI: 10.1210/endrev/bnad023
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The Emerging Therapeutic Potential of Kisspeptin and Neurokinin B

Abstract: Kisspeptin (KP) and neurokinin B (NKB) are neuropeptides that govern the reproductive endocrine axis through regulating hypothalamic gonadotropin-releasing hormone (GnRH) neuronal activity and pulsatile GnRH secretion. Their critical role in reproductive health was first identified after inactivating variants in genes encoding for KP or NKB signaling were shown to result in congenital hypogonadotropic hypogonadism (CHH) and a failure of pubertal development. Over the past two decades since their discovery, a w… Show more

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Cited by 15 publications
(2 citation statements)
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“…Conversely, excess kisspeptin signaling results in early activation of the reproductive endocrine axis and precocious puberty ( 3 ). Following a plethora of further research across several species, kisspeptin is now recognized to be a key regulator of reproductive hormones and controls the secretion of gonadotropin releasing hormone (GnRH) from dedicated neurons in the hypothalamus ( 4 , 5 ).…”
Section: Kisspeptin Regulates Gnrh Neurons In the Hypothalamusmentioning
confidence: 99%
“…Conversely, excess kisspeptin signaling results in early activation of the reproductive endocrine axis and precocious puberty ( 3 ). Following a plethora of further research across several species, kisspeptin is now recognized to be a key regulator of reproductive hormones and controls the secretion of gonadotropin releasing hormone (GnRH) from dedicated neurons in the hypothalamus ( 4 , 5 ).…”
Section: Kisspeptin Regulates Gnrh Neurons In the Hypothalamusmentioning
confidence: 99%
“…Neurokinin B (NKB) is a decapeptide (DMHDFFVGLM-amide) that plays a significant role in the nervous system [ 134 ]. It is a member of the tachykinin family of peptides.…”
Section: Factors Influencing Protein Aggregationmentioning
confidence: 99%