The end of the decline in cervical cancer mortality in Spain: trends across the period 1981–2012

Cervantes-Amat, Marta; López‐Abente, Gonzalo; Aragonés, Núria; Pollán, Marina; Pastor-Barriuso, Roberto; Pérez‐Gómez, Beatriz

doi:10.1186/s12885-015-1306-x

Cited by 12 publications

(13 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, our study illustrated that about half of all the reported cases and a third of the mortalities occurred in women of the reproductive age (15–49 years). The increasing rates of CC at young ages (25–49 years) in SA may be associated with the high prevalence of HIV in this age group, poor health care access (including screening), decreasing age at sexual debut and prevalent teenage pregnancy . However, initiation of ART in 2004 could have accounted for a reduction in mortality rates among women aged 20–24 (AAPC = −4.5%), since HIV/AIDS is a major driver of CC in young women.…”

Section: Discussionmentioning

confidence: 99%

Temporal trends in the epidemiology of cervical cancer in South Africa (1994–2012)

Olorunfemi

Ndlovu

Masukume

et al. 2018

Intl Journal of Cancer

View full text Add to dashboard Cite

Cervical cancer (CC) is the leading cause of cancer death among female South Africans (SA). Improved access to reproductive health services following multi-ethnic democracy in 1994, HIV epidemic, and the initiation of CC population-based screening in early 2000s have influenced the epidemiology of CC in SA. We therefore evaluated the trends in CC age-standardised incidence (ASIR) (1994-2009) and mortality rates (ASMR) (2004-2012) using data from the South African National Cancer Registry and the Statistics South Africa, respectively. Five-year relative survival rates and average per cent change (AAPC) stratified by ethnicity and age-groups was determined. The average annual CC cases and mortalities were 4,694 (75,099 cases/16 years) and 2,789 (25,101 deaths/9 years), respectively. The ASIR was 22.1/100,000 in 1994 and 23.3/100,000 in 2009, with an average annual decline in incidence of 0.9% per annum (AAPC = -0.9%, p-value < 0.001). The ASMR decreased slightly by 0.6% per annum from 13.9/100,000 in 2004 to 13.1/100,000 in 2012 (AAPC = -0.6%, p-value < 0.001). In 2012, ASMR was 5.8-fold higher in Blacks than in Whites. The 5-year survival rates were higher in Whites and Indians/Asians (60-80%) than in Blacks and Coloureds (40-50%). The incidence rate increased (AAPC range: 1.1-3.1%, p-value < 0.001) among young women (25-34 years) from 2000 to 2009. Despite interventions, there were minimal changes in overall epidemiology of CC in SA but there were increased CC rates among young women and ethnic disparities in CC burden. A review of the CC national policy and directed CC prevention and treatment are required to positively impact the burden of CC in SA.

show abstract

Section: Discussionmentioning

confidence: 99%

Temporal trends in the epidemiology of cervical cancer in South Africa (1994–2012)

Olorunfemi

Ndlovu

Masukume

et al. 2018

Intl Journal of Cancer

View full text Add to dashboard Cite

show abstract

“…Em Espanha foram reportados resultados semelhantes. 28 O exame citológico para deteção de CCU tem forte impacto na redução da mortalidade devido a esta forma de neoplasia. 3,7,8 Em Portugal esta forma de diagnóstico surgiu na década de 60, 29 mas foi exclusivamente utilizada para rastreios de forma oportunista durante a maior parte do período de tempo em análise.…”

Section: Discussionunclassified

“…No entanto, tal situação pode ser explicada pela não adesão a qualquer tipo de rastreio. Em Portugal, 31,32 à semelhança do observado em Espanha, 28 tem sido demonstrada uma menor prevalência de adesão ao exame citológico cervical em mulheres de idade mais avançada em comparação com as mais jovens.…”

Section: Discussionunclassified

Evolução Temporal da Mortalidade por Cancro do Colo do Útero em Portugal

Teixeira¹,

Pereira²,

Anes³

et al. 2019

Acta Med Port

View full text Add to dashboard Cite

Introduction: The mortality rate due to cervical cancer is higher in Portugal compared to other European countries. This study aimed to evaluate the time-trends in cervical cancer mortality rates observed in Portugal over the last six decades.Material and Methods: Age-standardized cervical cancer mortality rates reported in Portugal between 1955 and 2014, were collected from the International Agency for Research on Cancer (IARC). Joinpoint regression analysis was used to identify significant changes in mortality rates by assessing the percentage of annual variation (%AV) of the rate and respective 95% confidence interval (95%CI) according to the age groups.Results: Among women with 30–39 years, cervical cancer mortality decreased 1.9% per year (95%CI: –2.3; –1.4) throughout the time-period, reaching 0.5/100 000 in 2014. Among women aged 40–49 years, CC mortality decreased between 1971 and 1981 (%AV = –11.6; IC 95%: –14.6; –8.6). Rates then increased by 2.4% per year (95%CI: 1.0; 3.8) until 2001 and such trend reverted from 2001 onwards (%AV = –5.2; IC 95%: –7.7; –2.6), reaching 3.0/100 000 in 2014. In women aged 50–64, 65–74 and 75 years or older, cervical cancer mortality rates decreased from 29.2 to 6.7/100 000, from 34.3 to 7.7/100 000 and from 24.7 to 9.2/100 000. The decline in mortality rates in these three age groups occurred mainly between 1970 and 1980, and there have been no significant changes in the last three decades.Discussion: In Portugal, the most impressive decline in cervical cancer mortality rates occurred in the 1970s concurrently with changes in the National Healthcare System. The most important changes were the increased access to early diagnosis and the improvement in therapeutic approaches. The plateau that we observed among older women over the last three decades can be partially explained by factors with negative impact on adherence to cervical screening.Conclusion: There was a marked decrease in mortality due to CC among all age groups. However, we observed a plateau of this indicator in more advanced age groups over the last three decades. These findings suggest the need of promoting adherence to cervical screening in Portugal.

show abstract

“…7 A similar reallocation method has been applied for correcting the reported mortality for cervix and corpus uteri in all the European Union member states, 8,9 as well as revealing a rapidly increasing corpus uteri mortality trend in Korea, 10 and a halt in decreasing cervix uteri cancer mortality in Spain. 11 In this paper we present the corrected figures on mortality from and incidence of cervix and corpus uteri cancers in the Nordic countries for the years 1960-2016 by using reallocation of U-NOS deaths and cases. To further validate the accuracy of reallocation, we analyzed how well the reallocation captures the changes occurring as the results of a transition in cause of death coding in Norway from 2005 onwards.…”

Section: Introductionmentioning

confidence: 99%

Setting the record straight—Correcting uterine cancer incidence and mortality in the Nordic countries by reallocation of unspecified cases

Partanen

Heinävaara

Anttila

et al. 2022

Acta Obstet Gynecol Scand

View full text Add to dashboard Cite

Introduction The incidence of and mortality from cancers of the cervix uteri and corpus uteri are underestimated if the presence of uterine cancers, where the exact topography (site of origin) is not specified, is omitted. In this paper we present the corrected figures on mortality from and incidence of cervix and corpus uteri cancers in the Nordic countries by reallocating unspecified uterine cancer deaths and cases to originate either from the corpus uteri or cervix uteri. To further validate the accuracy of reallocation, we also analyzed how well the reallocation captures the changes occurring as the result of a transition in cause of death coding in Norway that took place in 2005. Material and Methods This study uses data available in the NORDCAN database, which contains aggregated cancer data from all the Nordic countries for the years 1960–2016. The unspecified uterine cancer cases and deaths were reallocated to either cervix uteri or corpus uteri based on the estimated probability that follows the distribution of cases and deaths with verified topography. The estimated proportions of cases and deaths for both cancers were calculated for each combination of age group, year, and country as a proportion of cases (and deaths, respectively) with known topography. Annual age‐standardized rates were calculated by direct age‐adjustment. Results The proportions of unspecified uterine cancers were higher in the mortality data than in incidence data, with mean values for 1960–2016 ranging between 5.1% and 26.6% and between 0.2% and 6.8% by country, respectively. In the Nordic countries combined, the reallocation increased the number of cases by 4% and deaths by approximately 20% for both cancers. Finland was the only Nordic country where the mortality rate did not increase substantially after reallocation. Conclusions The reallocation procedure had a significant impact on mortality from cancers of the cervix and corpus uteri for countries where the proportion of cancer deaths coded as uterus, not otherwise specified, is substantial. More effort to validate cause of death data with incidence data from cancer registries is warranted to avoid erroneous conclusions of temporal trends based on uncorrected cancer burden.

show abstract

The end of the decline in cervical cancer mortality in Spain: trends across the period 1981–2012

Cited by 12 publications

References 27 publications

Temporal trends in the epidemiology of cervical cancer in South Africa (1994–2012)

Temporal trends in the epidemiology of cervical cancer in South Africa (1994–2012)

Evolução Temporal da Mortalidade por Cancro do Colo do Útero em Portugal

Setting the record straight—Correcting uterine cancer incidence and mortality in the Nordic countries by reallocation of unspecified cases

Contact Info

Product

Resources

About