2010
DOI: 10.1016/j.jnutbio.2010.04.011
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The endocannabinoid signaling system: a marriage of PUFA and musculoskeletal health

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Cited by 32 publications
(29 citation statements)
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“…Higher n-3 PUFA intake reduces oxidative stress and inflammation that may affect obesity related comorbidities and bone metabolism [144147]. In addition, PUFA alters endocannobanoids production and release and CB1/CB2 gene expression, and this may be another mechanism whereby PUFA affects the fate of osteoblast and osteoclast in obesity and chronic over-activated ECS system [145, 148150]. Furthermore, monounsaturated fatty acids (MUFA) intake from dietary olive, olive, and nuts also show a beneficial or neural effect on bone health.…”
Section: Dietary Energy and Fat On Bone In Preclinical Studiesmentioning
confidence: 99%
“…Higher n-3 PUFA intake reduces oxidative stress and inflammation that may affect obesity related comorbidities and bone metabolism [144147]. In addition, PUFA alters endocannobanoids production and release and CB1/CB2 gene expression, and this may be another mechanism whereby PUFA affects the fate of osteoblast and osteoclast in obesity and chronic over-activated ECS system [145, 148150]. Furthermore, monounsaturated fatty acids (MUFA) intake from dietary olive, olive, and nuts also show a beneficial or neural effect on bone health.…”
Section: Dietary Energy and Fat On Bone In Preclinical Studiesmentioning
confidence: 99%
“…Concerning the musculoskeletal compartment, evidence exists for a correlation between dietary ω-6/ω-3 ratio and levels of ARA-and ω-3-derived endocannabinoids [91,100,101]. More interestingly, addition of free ω-3 in the culture medium of osteoblastes changes the level of proteins of the endocannabinoid system: CB2 receptors and NAPE-PLD [101].…”
Section: Endocannabinoids Derived From ω-3 Pufasmentioning
confidence: 99%
“…The endocannabinoid (EC) system is comprised of receptors, ligands, and enzymes for the synthesis and degradation of the endogenous ligands [1]. The two most studied endogenous cannabinoid ligands are synthesized from arachidonic acid (AA) by N-acyl phosphatidylethanolamine-selective phospholipase D (NAPE-PLD) or diacylglycerol lipases (DAGL) α and β to form Narachidonoylethanolamide (anandamide, AEA) and 2-arachidonoylglycerol (2-AG), respectively [1].…”
Section: Introductionmentioning
confidence: 99%
“…The two most studied endogenous cannabinoid ligands are synthesized from arachidonic acid (AA) by N-acyl phosphatidylethanolamine-selective phospholipase D (NAPE-PLD) or diacylglycerol lipases (DAGL) α and β to form Narachidonoylethanolamide (anandamide, AEA) and 2-arachidonoylglycerol (2-AG), respectively [1]. Fatty acid amide hydrolase (FAAH) hydrolyzes AEA to yield AA and an ethanolamide.…”
Section: Introductionmentioning
confidence: 99%
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