The endogenous oxytocin system in depressive disorders: A systematic review and meta-analysis

Engel, Sinha; Laufer, Sebastian; Knaevelsrud, Christine; Schumacher, Sarah

doi:10.1016/j.psyneuen.2018.11.011

Cited by 42 publications

(32 citation statements)

References 59 publications

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“…A balanced activity of the OXT and AVP system within the CNS appears to be crucial for mental health, with central OXT and AVP effects on anxiety and depression‐like behaviour being characterised in a number of studies . However, the value of OXT and AVP as biomarkers in psychiatric disorders remains unclear because studies have demonstrated varied results and, in most cases, peripheral neuropeptide levels are determined . As far as OXT is concerned, we found no correlation of blood, CSF or saliva concentrations with either the anxiety or depression score of the HADS.…”

Section: Discussioncontrasting

confidence: 57%

“…4 However, the value of OXT and AVP as biomarkers in psychiatric disorders remains unclear because studies have demonstrated varied results and, in most cases, peripheral neuropeptide levels are determined. 11,34 As far as OXT is concerned, we found no correlation of blood, CSF or saliva concentrations with either the anxiety or depression score of the HADS. These results are not completely unexpected because, in a recent review, Engel et al 34 found very heterogeneous results concerning the role of endogenous OXT levels in human psychopathology.…”

Section: Neuropeptide Levels and Hads Scorementioning

confidence: 64%

“…As far as OXT is concerned, we found no correlation of blood, CSF or saliva concentrations with either the anxiety or depression score of the HADS. These results are not completely unexpected because, in a recent review, Engel et al found very heterogeneous results concerning the role of endogenous OXT levels in human psychopathology. In their meta‐analysis, basal OXT levels did not differ between depressive patients and healthy controls .…”

Section: Discussionmentioning

confidence: 79%

“…These results are not completely unexpected because, in a recent review, Engel et al found very heterogeneous results concerning the role of endogenous OXT levels in human psychopathology. In their meta‐analysis, basal OXT levels did not differ between depressive patients and healthy controls . Studies on peripheral AVP levels in psychopathology also reveal inconsistent findings .…”

Section: Discussionmentioning

confidence: 79%

“…In their meta-analysis, basal OXT levels did not differ between depressive patients and healthy controls. 34 Studies on peripheral AVP levels in psychopathology also reveal inconsistent findings. 11 In the present study, we showed a sig- separately in the present study, only men showed significant negative correlations between HADS scores and AVP blood concentrations.…”

Section: Neuropeptide Levels and Hads Scorementioning

confidence: 99%

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Influence of perioperative stress on central and peripheral oxytocin and arginine‐vasopressin concentrations

Kagerbauer

Martin

Ulm

et al. 2019

J Neuroendocrinology

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Perioperative stress provides not only physical, but also psychic and emotional aspects, which may influence the hypothalamic neuropeptide system. Studies investigating the perioperative course of central neuropeptide activity are missing. Therefore, the present study aimed to determine perioperative fluctuations in central and concomitant peripheral concentrations of the hypothalamic neuropeptides oxytocin (OXT) and arginine‐vasopressin (AVP), as well as their impact on perioperative anxiety and depression. Cerebrospinal fluid (CSF), blood and saliva were collected from 12 patients who underwent elective endovascular aortic repair with a routinely inserted spinal catheter. AVP and OXT concentrations were analysed at four timepoints: (i) the evening before the operation; (ii) the operation day immediately before anaesthesia induction; (iii) intraoperatively after the stent was placed; and (iv) on day 1 after the operation. Patients completed the Hospital Anxiety and Depression Scale (HADS) at timepoints 1 and 4. For CSF OXT, the present study showed a significant intraoperative decline, accompanied by a decrease in saliva. OXT blood concentrations before anaesthesia induction were higher than at the evening before the operation. OXT concentrations in CSF and saliva correlated well at timepoints 2‐4. AVP concentrations in CSF, blood and saliva did not show any significant changes perioperatively. However, postoperative AVP blood concentrations showed a significant negative correlation with anxiety and depression scores according to the HADS. This pilot study demonstrates perioperative fluctuations in central OXT concentrations, which are better reflected by saliva than by blood. Further studies are required to determine whether OXT and AVP can predict postoperative post‐traumatic stress disorder.

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Section: Discussioncontrasting

confidence: 57%

Section: Neuropeptide Levels and Hads Scorementioning

confidence: 64%

Section: Discussionmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 79%

Section: Neuropeptide Levels and Hads Scorementioning

confidence: 99%

See 3 more Smart Citations

Influence of perioperative stress on central and peripheral oxytocin and arginine‐vasopressin concentrations

Kagerbauer

Martin

Ulm

et al. 2019

J Neuroendocrinology

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Whole-Body Hyperthermia (WBH) in Psychiatry

Knobel,

Hanusch,

Auen

et al. 2022

Water-Filtered Infrared a (wIRA) Irradiation

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New effective therapies for managing and treating psychiatric disorders such as major depression are urgently needed. Mood-enhancing effects have repeatedly been observed after whole-body hyperthermia (WBH) treatment in other medical disciplines, and there is promising evidence that WBH may be used in psychiatry for patients suffering from depressive disorders. Most importantly, a recent study demonstrated a significant, rapid, and partially lasting reduction of depressive symptoms in patients with major depressive disorder following a single session of water-filtered infrared-A induced whole-body hyperthermia (wIRA-WBH). Underlying mechanisms of actions may include immune modulation and serotonergic neurotransmission via warm-sensitive afferent thermosensory pathways to the midbrain.Current studies are focused on verifying these earlier findings and clarifying the mechanisms involved. Herein, we report on the establishment of WBH methodology in the psychiatry setting and provide our opinions on necessary future research.

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The cellular and molecular basis of major depressive disorder: towards a unified model for understanding clinical depression

et al. 2019

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The endogenous oxytocin system in depressive disorders: A systematic review and meta-analysis

Cited by 42 publications

References 59 publications

Influence of perioperative stress on central and peripheral oxytocin and arginine‐vasopressin concentrations

Influence of perioperative stress on central and peripheral oxytocin and arginine‐vasopressin concentrations

Whole-Body Hyperthermia (WBH) in Psychiatry

The cellular and molecular basis of major depressive disorder: towards a unified model for understanding clinical depression

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