The endolymphatic sac tumor: challenges in the eradication of a localized disease

Sykopetrites, Vittoria; Piras, Gianluca; Giannuzzi, Annalisa; Caruso, Antonio; Taibah, Abdelkader; Sanna, Mario

doi:10.1007/s00405-020-06323-x

Cited by 12 publications

(20 citation statements)

References 42 publications

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“…In this case, we can see that the amount of blood loss in the 2 operations before and after vascular embolization was 3000 and 500 mL, respectively. Advanced ELSTs often involve the facial nerve, but in most cases, the tumors can only destroy the fallopian canal 3 . At this time, it is necessary to dissect the facial nerve from the tumor to maintain the integrity of the facial nerve.…”

Section: Discussionmentioning

confidence: 99%

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The Diagnosis and Management of Advanced Endolymphatic Sac Tumor

Zhang

Guo

et al. 2023

Journal of Craniofacial Surgery

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Endolymphatic sac tumor (ELST) is a group of low-grade malignant tumors originating from the endolymphatic sac of the inner ear. It is rare in the clinic and has the biological characteristics of slow growth and local aggression. Due to the lack of specificity in the clinical manifestations of patients with ELST, many cases have entered the advanced stage at the time of diagnosis. However, there are still great challenges in the treatment of advanced ELSTs. Here, the authors describe a case of advanced ELST, which relapsed after 2 operations. This time, the authors chose the transotic approach for tumor resection, which achieved the goal of complete resection of the tumor, and the patient recovered smoothly after surgery. There were no surgical complications and no tumor recurrence after the follow-up. Through literature review and our own experience, the authors suggest that complete surgical resection is the first choice for both primary and recurrent advanced ELSTs. The choice of a reasonable surgical approach is the key to ensuring complete resection of the tumor, while preoperative angiography and embolization, fine treatment of important structures during surgery, and postoperative long-term follow-up are equally important for patients with advanced ELST to obtain a good prognosis.

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Section: Discussionmentioning

confidence: 99%

“…Surgical resection is the mainstream management for ELST 3,4 . For early tumors, the auditory function can be preserved based on complete tumor resection 5 .…”

mentioning

confidence: 99%

The Diagnosis and Management of Advanced Endolymphatic Sac Tumor

Zhang

Guo

et al. 2023

Journal of Craniofacial Surgery

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“…To our knowledge, this is the largest systematic review of ELSTs to date. Compared to previous literature reviews on ELSTs, 21,23,28 our systematic review presents information on symptomaticity, tumor characteristics, treatment modalities, surgical approaches, outcomes, and patient follow-up. ELSTs are rare neoplasms that require a high degree of suspicion for early diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“…Gross total resection may be technically difficult to achieve, with a recent case series and literature review by Sykopetrites et al 23 presenting 29.3% recurrent or residual tumor after surgical resection in the current literature. Our study of primary tumors reports a similar figure; 173 cases provided information on totality of resection, and of those, 45 were resected incompletely.…”

Section: Treatment and Outcomesmentioning

confidence: 99%

Systematic Review of Endolymphatic Sac Tumor Treatment and Outcomes

Tang

Grady

Nickel

et al. 2022

Otolaryngol.--head neck surg.

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Objective Endolymphatic sac tumors are rare neoplasms originating in the endolymphatic sac. Current literature is limited to case reports and small case series. The objective of this study was to systematically review the literature to better describe clinical presentation, treatment options, and outcomes in endolymphatic sac tumors. Data Source PubMed, Embase, and Cochrane Library. Review Methods A systematic review was performed following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines describing human endolymphatic sac tumors. Risk of bias was assessed using a validated critical appraisal checklist for case series. Studies without inclusion of individual patient characteristics, corresponding treatments, and outcomes were excluded. Heterogeneity of data precluded meta-analysis. Results A total of 82 studies met inclusion criteria, and 253 discrete tumors were analyzed. A total of 23.4% of patients had von Hippel-Lindau disease. Von Hippel-Lindau–associated tumors affected females to males in a 2.4:1 ratio. Patients with von Hippel-Lindau disease displayed earlier average age at diagnosis compared to the sporadic cohort. Surgery was the primary treatment modality and was performed in 88.9% of cases. Adjuvant radiation therapy was employed in 18.7% of cases; 16.2% cases recurred, and 10.6% had progression of residual disease after treatment. Mean time to recurrence or progression was 53.1 ± 52.4 months with a range of 3 to 240 months. Conclusion Endolymphatic sac tumors require a high degree of suspicion for early diagnosis. Complete resection is the standard of care. No strong evidence supports routine use of adjuvant radiation therapy. Given the high rate of recurrence and wide-ranging time to recurrence, long-term follow-up is necessary.

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“…Diaz et al сообщили о 134 случаях опухоли височных костей, пролеченных с 1994 по 2005 г.: 78% из них составили параганглиомы, 4% -шванномы яремного отверстия, 4% -гемангиомы, 4% -шванномы лицевого нерва, 4% -ОЭМ, 3% -метастазы, 1% -аденома среднего уха, 1% -хондросаркомы [79].…”

Section: диссертантunclassified

Endolymphatic sac tumor: rewiev of literature

et al. 2022

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Endolymphatic sac tumors are rare neoplasms of the temporal bone, histologically benign, but clinically behaves as malignant tumors causing destruction of surrounding tissues. The tumor originates from the posterior surface of petrous part of temporal bone, where endolymphatic sac is situated anatomically. The tumor causes destruction of the posterior surface of the petrous part of the temporal bone, inner ear, mastoid process, etc. Endolymphatic sac tumor can be both sporadically and in patients with von Hippel – Lindau disease. Due to the rarity of this tumor, it is easy to confuse it with other tumors, such as paraganglioma, middle ear adenoma, adenocarcinoma, papillary thyroid carcinoma or papilloma of the vascular plexus. Computed tomography (CT) and magnetic resonance imaging (MRI) are of great diagnostic importance and play an important role in planning treatment tactics. The optimal method of treatment is resection of pathologically altered tissues. In some cases (incomplete resection of tumor, the patients with concomitant diseases or inoperable cases) receive courses of X-ray or radiosurgery. If a tumor is detected in the early stages, the volume of resection can be minimized while preserving hearing and vestibular function of the inner ear. Recurrence usually happens due to difficulty to identify the extension of the tumor. Diagnosis and correct preoperative planning, with embolization if it possible, will facilitate surgery and avoid subtotal tumor resection due to intraoperative bleeding. Long follow-up period is important in order to avoid recurrences. Insufficient coverage of this problem in the literature is associated with a low percentage of its occurrence in otosurgical practice, which complicates the timely diagnosis and treatment of this type of tumors of the temporal bone, worsens the prognosis.

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The endolymphatic sac tumor: challenges in the eradication of a localized disease

Cited by 12 publications

References 42 publications

The Diagnosis and Management of Advanced Endolymphatic Sac Tumor

The Diagnosis and Management of Advanced Endolymphatic Sac Tumor

Systematic Review of Endolymphatic Sac Tumor Treatment and Outcomes

Endolymphatic sac tumor: rewiev of literature

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