The Enhancing Effect of Spawning on Elimination of a Persistent Polychlorinated Biphenyl from Female Yellow Perch

Vodicnik, Mary Jo; Peterson, Richard E.

doi:10.1093/toxsci/5.4.770

Cited by 19 publications

(25 citation statements)

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“…A mutant form of p53 occurs in leukemic clams taken from PCB-contaminated sites (13). Developing larvae are particularly at risk because up to 50% of the PCB burden of an animal can be redistributed to the gonad during oogenesis (44). In our study we exposed early embryos to Aroclor 1254, a defined mixture of orthosubstituted (noncoplanar) and coplanar PCBs.…”

Section: Discussionmentioning

confidence: 99%

A new invertebrate member of the p53 gene family is developmentally expressed and responds to polychlorinated biphenyls.

Jessen-Eller

Kreiling

Begley

et al. 2002

Environ Health Perspect

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The cell-cycle checkpoint protein p53 both directs terminal differentiation and protects embryos from DNA damage. To study invertebrate p53 during early development, we identified three differentially expressed p53 family members (p53, p97, p120) in the surf clam, Spisula solidissima. In these mollusks, p53 and p97 occur in both embryonic and adult tissue, whereas p120 is exclusively embryonic. We sequenced, cloned, and characterized p120 cDNA. The predicted protein, p120, resembles p53 across all evolutionarily conserved regions and contains a C-terminal extension with a sterile alpha motif (SAM) as in p63 and p73. These vertebrate forms of p53 are required for normal inflammatory, epithelial, and neuronal development. Unlike clam p53 and p97, p120 mRNA and protein levels are temporally expressed in embryos, with mRNA levels decreasing with increasing p120 protein (R(2) = 0.97). Highest surf clam p120 mRNA levels coincide with the onset of neuronal growth. In earlier work we have shown that neuronal development is altered by exposure to polychlorinated biphenyls (PCBs), a neurotoxic environmental contaminant. In this study we show that PCBs differentially affect expression of the three surf clam p53 family members. p120 mRNA and protein are reduced the most and earliest in development, p97 protein shows a smaller and later reduction, and p53 protein levels do not change. For the first time we report that unlike p53 and p97, p120 is specifically embryonic and expressed in a time-dependent manner. Furthermore, p120 responds to PCBs by 48 hr when PCB-induced suppression of the serotonergic nervous system occurs.

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Section: Discussionmentioning

confidence: 99%

A new invertebrate member of the p53 gene family is developmentally expressed and responds to polychlorinated biphenyls.

Jessen-Eller

Kreiling

Begley

et al. 2002

Environ Health Perspect

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“…This makes the reproduction success of the fish susceptible for lipophilic persistent compounds that are accumulated by the mother fish and transported to the eggs during gametogenesis (Solbakken et al, 1984;Vodicnic and Peterson, 1985).…”

Section: Field Relevancementioning

confidence: 99%

Prolonged ELS test with the marine flatfish sole (Solea solea) shows delayed toxic effects of previous exposure to PCB 126

Foekema¹,

Deerenberg²,

Murk

2008

Aquatic Toxicology

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“…Concentrations of TCB ranging from 0.002 to 0.068 ug/g wet weight have been measured in the white muscle of striped bass from the Hudson River (Hong and Bush 1990). Lipophilic compounds, such as PCBs tend to accumulate to a greater degree in tissues with high lipid contents such as the ovaries or liver (Vodicnik and Peterson 1985). PCB concentrations measured in eggs obtained from Hudson River striped bass were 10-20 fold greater than in the white muscle (Westin et al 1983).…”

Section: Steroidmentioning

confidence: 99%

Blood Plasma Levels of Sex Steroid Hormones and Vitellogenin in Striped Bass ( Morone saxatilis ) Exposed to 3,3',4,4'-Tetrachlorobiphenyl (TCB)

Monosson

Hogson

Fleming³

et al. 1996

Bulletin of Environmental Contamination and Toxicology

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The Enhancing Effect of Spawning on Elimination of a Persistent Polychlorinated Biphenyl from Female Yellow Perch

Cited by 19 publications

References 0 publications

A new invertebrate member of the p53 gene family is developmentally expressed and responds to polychlorinated biphenyls.

A new invertebrate member of the p53 gene family is developmentally expressed and responds to polychlorinated biphenyls.

Prolonged ELS test with the marine flatfish sole (Solea solea) shows delayed toxic effects of previous exposure to PCB 126

Blood Plasma Levels of Sex Steroid Hormones and Vitellogenin in Striped Bass ( Morone saxatilis ) Exposed to 3,3',4,4'-Tetrachlorobiphenyl (TCB)

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