2003
DOI: 10.1016/s0958-1669(03)00092-2
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The enzyme as drug: application of enzymes as pharmaceuticals

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Cited by 250 publications
(141 citation statements)
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“…tion, approval, and use in humans of several recombinant enzyme products such as ADAGEN (ERT to treat adenosine deaminase deficiency and SCID), Pulmozyme (to treat cystic fibrosis), pegloticase (to treat gout), and more (37,38), attests to the applicability of enzyme therapies in humans. Our proposed ERT thus provides a therapeutic strategy for CBSDH patients that allows for the prevention or treatment of symptoms and relaxes the need to maintain a strict diet.…”
Section: Author Contributionsmentioning
confidence: 99%
“…tion, approval, and use in humans of several recombinant enzyme products such as ADAGEN (ERT to treat adenosine deaminase deficiency and SCID), Pulmozyme (to treat cystic fibrosis), pegloticase (to treat gout), and more (37,38), attests to the applicability of enzyme therapies in humans. Our proposed ERT thus provides a therapeutic strategy for CBSDH patients that allows for the prevention or treatment of symptoms and relaxes the need to maintain a strict diet.…”
Section: Author Contributionsmentioning
confidence: 99%
“…D espite the many attractive features of protein enzymes as catalysts for organic synthesis (1), as research tools (2)(3)(4), and as an important class of human therapeutics (5,6), the extent and diversity of their applications remain limited by the difficulty of finding in nature or creating in the laboratory highly active proteins that catalyze chemical reactions of interest. A significant fraction of protein catalysts currently used for research and industrial applications was obtained through the directed evolution of natural enzymes (7).…”
mentioning
confidence: 99%
“…celiac sprue | prolyl oligopeptidase | autoimmune disease E xogenous enzymes are being tested or already used orally to treat several diseases, including pancreatic insufficiency, lactose intolerance, and phenylketonuria (1,2). However, harsh pH changes and the presence of proteases in the gastrointestinal (GI) environment can strongly alter the activity of orally-administered enzymes.…”
mentioning
confidence: 99%