The Epidemiologic and Genetic Aspects of an Outbreak of Leukemia Among Hamadryas Baboons of the Sukhumi Monkey Colony

Ba, Lapin

doi:10.1159/000427851

Cited by 16 publications

(16 citation statements)

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“…One of the ¢rst simian LCVs identi¢ed was from baboons at the Institute of Experimental Pathology, USSR Academy of Medical Sciences at Sukhumi. An outbreak of lymphomas in this baboon colony was recognized, beginning in 1967 (Lapin 1974), and lymphoid cell lines containing herpes particles and expressing a crossreactive VCA were established from lymphomatous baboons (Djatchenko et al 1976;Rabin et al 1977). Simian LCV-infected lymphoblastoid cell lines were also established by other investigators using peripheral blood lymphocytes from normal, healthy baboons (Falk et al 1976).…”

Section: Historical Perspectivementioning

confidence: 99%

Simian homologues of Epstein–Barr virus

Wang

Rivailler

Rao

et al. 2001

Phil. Trans. R. Soc. Lond. B

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g-Herpesviruses closely related to the Epstein^Barr virus (EBV) are known to naturally infect Old World non-human primates and are classi¢ed in the same lymphocryptovirus (LCV) genera. LCV infecting humans and Old World primates share similar biology, and recent studies have demonstrated that these viruses share a similar repertoire of viral genes. Surprisingly, the latent infection genes associated with cell growth transformation demonstrate the most striking sequence divergence, but the functional mechanisms for these genes are generally well conserved. The recent discovery of LCVs naturally infecting New World primates has rewritten the old paradigm of LCV host range restriction to humans and Old World non-human primates, so that these viruses are more widespread than previously believed. However, the New World LCV genome has signi¢cant and interesting di¡erences from EBV and other Old World LCVs despite similar biological properties. Thus, the simian homologues of EBV can provide an important animal model for studying LCV pathogenesis, and the similarities and di¡erences that have evolved among these related viruses can provide a unique perspective towards a better understanding of EBV.

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Section: Historical Perspectivementioning

confidence: 99%

Simian homologues of Epstein–Barr virus

Wang

Rivailler

Rao

et al. 2001

Phil. Trans. R. Soc. Lond. B

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“…The cases occurred after the introduction into the colony of several baboons which had been inoculated with human leukemic blood. Disease was seen mainly in sexually mature, colony-born monkeys over 5 years of age [1,2].…”

mentioning

confidence: 99%

Transforming Activity and Antigenicity of an Epstein-Barr-Like Virus from Lymphoblastoid Cell Lines of Baboons with Lymphoid Disease

Rabin¹,

Neubauer²,

Hopkins³

et al. 1977

Intervirology

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Two lymphoblastoid cell lines were established from baboons with lymphoid disease. Cells of these lines were positive for complement and Fc receptors but lacked sheep cell receptors, thereby indicating B-cell origin. The cells contained antigens which cross-reacted with Epstein-Barr virus (EBV), viral capsid antigen (VCA), early antigen (EA) and membrane antigen (MA). Both lines released virus with in vitro transforming activity for lymphocytes of several primate species including humans. Cells of the original lines and transformed cells showed no staining for EB nuclear antigen (EBNA). The virus was neutralized by anti-MA positive baboon and human sera. Baboon virus and EBV had different but overlapping in vitro host-cell ranges.

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“…The baboon lymphomas at Sukhumi have all occurred in sexually mature monkeys over five years of age that were born in the colony [16], While a type-C virus has been implicated in the etiology of this disease, it was of interest to examine individual cases for other virus isolates.…”

Section: Discussionmentioning

confidence: 99%

“…Multiple cases of lymphoma have occurred in captivity in four species of nonhuman primates: owl monkeys (Aotus trivirgatus) [9,21]; rhesus mon keys (Macaco mulatta) [23]; gibbons (Hylobates lar) [12,13]; and baboons (Papio hamadryas) [16]. A known oncogenic herpesvirus, Herpesvirus saimiri (HVS), was shown to be associated with the spontaneous lymphomas in owl monkeys.…”

Section: Introductionmentioning

confidence: 99%

“…Evidence suggesting transmissibility of granulocytic leukemia in gibbons via a type-C virus has been obtained [14]. In rhesus monkeys, epidemiological evidence suggests a transmissible agent and there is a report of a foamyvirus isolation from one spontaneous case [20], In the baboons, cases of leukemia occurred in animals which had been in contact with one another or had received inoculations of blood or filtrates of leukemic tissue, and it has been suggested that a type-C virus may be in volved in the etiology of the disease [16].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Virological Studies of Baboon (Papio hamadryas) Lymphoma : Isolation and Characterization of Foamyviruses

Rabin¹,

Neubauer²,

Woodside³

et al. 1976

J Med Primatol

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In accordance with a memorandum of understanding in cancer research between scientists in the USSR and the USA, virological studies were performed on two baboons from the Russian colony at the Institute of Experimental Pathology and Therapy at Sukhumi where several cases of leukemia have been observed over the past few years. Foamyvirus isolations were made from lymphoid cells of both of these monkeys, one of which had a confirmed case of lymphoma. The isolates were similar to each other serologically and morphologically, possessed characteristics typical of foamyviruses, and crossreacted to a low level with antibody to simian foamyvirus type 1.

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The Epidemiologic and Genetic Aspects of an Outbreak of Leukemia Among Hamadryas Baboons of the Sukhumi Monkey Colony

Cited by 16 publications

References 0 publications

Simian homologues of Epstein–Barr virus

Simian homologues of Epstein–Barr virus

Transforming Activity and Antigenicity of an Epstein-Barr-Like Virus from Lymphoblastoid Cell Lines of Baboons with Lymphoid Disease

Virological Studies of Baboon (Papio hamadryas) Lymphoma : Isolation and Characterization of Foamyviruses

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