The epidermal immune microenvironment plays a dominant role in psoriasis development, as revealed by mass cytometry

Zhou, Yuan; Xu, Fangying; Chen, Xueyan; Yan, Binjun; Wang, Zhao-Yuan; Chen, Si-Qi; Zheng, Min; Man, Xiao‐Yong

doi:10.1038/s41423-022-00940-8

Cited by 21 publications

(22 citation statements)

References 53 publications

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“…Within the skin microenvironment, a diverse array of immune cells orchestrates the maintenance of immunological balance [29], while nonimmune cellular constituents, notably keratinocytes, modulate immune cell behavior through cytokine secretion [30]. These cytokines exert profound effects on immune cell function and play pivotal roles in the initiation, propagation, and perpetuation of cutaneous in ammation [31]. Given in ammation's dual nature, keratinocytes often act as initiators of the in ammatory cascade in numerous in ammatory skin disorders [32].…”

Section: Discussionmentioning

confidence: 99%

Investigating the Epidermal Anti-inflammatory Properties of Paris Polyphylla through Network Pharmacology and Experimental Studies

Wang,

Yang

et al. 2024

Preprint

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Background: Epidermal inflammation, often triggered by environmental exposure or pathological conditions, is intricately associated with tissue damage and various skin diseases. Methods:This study employed network pharmacology and cell experiments to validate the anti-inflammatory mechanism of Paris polyphylla. Results: Paris polyphylla targets crucial inflammation-related genes such as IL6, IL-1B, TNF, and CXCL8 within its protein-protein interaction (PPI) network. Pathway analysis revealed significant enrichment not only in inflammatory factor processes but also in toll-like receptor, MAPK, and NF-κB pathways. Key nodes in the PPI network include TLR4, MAPK3, and MYD88. Molecular docking demonstrated robust binding of Polyphyllin H, a component of Paris polyphylla, with MAPK3 and MYD88, suggesting its potential in modulating skin inflammation. Paris polyphylla exhibited the ability to attenuate the upregulation of IL-1β, IL-6, IL-8, and TNF-α in both UVA-damaged and LPS-bacteria stimulated HaCat models. Conclusions: Thus, Paris polyphylla may regulate the TLR4 pathway through MYD88 and MAPK3, alleviating epidermal inflammation induced by MAPK pathway and NFκB activation. These findings underscore the promise of Paris polyphylla in ameliorating skin damage and diseases, underscoring its significance in dermatology and cosmetics.

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Section: Discussionmentioning

confidence: 99%

Investigating the Epidermal Anti-inflammatory Properties of Paris Polyphylla through Network Pharmacology and Experimental Studies

Wang,

Yang

et al. 2024

Preprint

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“…Ultrastructural studies show integrin chains’ distribution in the basal cell layer of the squamous epithelium, which is crucial for the interaction between the epithelium and basal lamina [ 20 ]. The interactions between them can be altered during the first steps of dysplastic transformations that come before micro-invasive cervical cancer [ 21 , 22 , 23 ].…”

Section: Discussionmentioning

confidence: 99%

The Role of β1 Integrin/CD29 as a Potential Prognostic Factor for the Risk of Progression to Cervical Carcinoma in HPV-Associated Lesions

Schettino,

Preti,

Vietri

et al. 2024

Medicina

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Background and Objectives: Available evidence reports the overexpression of β1 integrin in dysplastic rather than normal cervical tissue. We aimed to evaluate the involvement of β1 (CD29) integrin in the progressive pathogenesis of cervical intraepithelial neoplasia (CIN). Materials and Methods: From January 2019 to December 2021, we prospectively enrolled women undergoing a colposcopy with a cervical biopsy for abnormal cervical cytology and/or undefined cytology with a positive HPV DNA test and women with relapsing cervical inflammatory disorders. Based on the histopathological results, women were divided into four groups: group A (CIN1), group B (CIN2), group C (CIN3), and group D (no CIN diagnosis) as a control group. Subsequently, cytofluorimetry and immunohistochemical analysis (based on the identified positive cell ratios as follows: ≤10%, negative; 10–25%, 1+ (weak); 25–50%, 2+ (medium); ≥50%, and 3+ (high)) for β1 integrin were carried out. Results: In total, 154 women were included. The average fluorescence intensity in the four groups was 2.35 ± 1.37, 2.73 ± 1.56, 3.09 ± 1.56, and 2.13 ± 1.25 UA from groups A to D, respectively; this figure was significantly different for CIN3 (group C) women relative to the other groups (p = 0.0132). Higher β1 integrin/CD29 concentrations in the CIN groups with HR-HPV 16 and 18 were also detected (p = 0.0292, 0.0367, and 0.0357 respectively for CIN3, CIN2, and CIN1). Immunohistochemistry analysis showed higher results for the CIN3 group compared to controls and all the other groups (p < 0.001). Conclusions: β1/CD29 integrin expression increased with CIN grade, and it was significantly higher in CIN3 lesions. This could be used as a promising screening tool to identify women prone to developing high-grade cervical lesions. However, additional evidence is needed to strengthen these findings.

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“…Once DCs detect potential threats, they initiate the immune response process ( 101 ). Dermal CD1c + CD11b + cDC2s migrate to the surrounding skin epidermis in the early stage of psoriasis, causing rapid inflammation ( 102 ).DCs bridge the innate and adaptive immune systems. Activated DCs up-regulate co-stimulatory molecules and generate cytokines, which activate T cells and induce their differentiation into effector cells for carrying out specific immune functions.…”

Section: Inflammatory Role Of Immune Cells In Psoriasismentioning

confidence: 99%

Immune cells in the epithelial immune microenvironment of psoriasis: emerging therapeutic targets

Li,

Lu,

Liu

et al. 2024

Front. Immunol.

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Psoriasis is a chronic autoimmune inflammatory disease characterized by erroneous metabolism of keratinocytes. The development of psoriasis is closely related to abnormal activation and disorders of the immune system. Dysregulated skin protective mechanisms can activate inflammatory pathways within the epithelial immune microenvironment (EIME), leading to the development of autoimmune-related and inflammatory skin diseases. In this review, we initially emphasized the pathogenesis of psoriasis, paying particular attention to the interactions between the abnormal activation of immune cells and the production of cytokines in psoriasis. Subsequently, we delved into the significance of the interactions between EIME and immune cells in the emergence of psoriasis. A thorough understanding of these immune processes is crucial to the development of targeted therapies for psoriasis. Finally, we discussed the potential novel targeted therapies aimed at modulating the EIME in psoriasis. This comprehensive examination sheds light on the intricate underlying immune mechanisms and provides insights into potential therapeutic avenues of immune-mediated inflammatory diseases.

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The epidermal immune microenvironment plays a dominant role in psoriasis development, as revealed by mass cytometry

Cited by 21 publications

References 53 publications

Investigating the Epidermal Anti-inflammatory Properties of Paris Polyphylla through Network Pharmacology and Experimental Studies

Investigating the Epidermal Anti-inflammatory Properties of Paris Polyphylla through Network Pharmacology and Experimental Studies

The Role of β1 Integrin/CD29 as a Potential Prognostic Factor for the Risk of Progression to Cervical Carcinoma in HPV-Associated Lesions

Immune cells in the epithelial immune microenvironment of psoriasis: emerging therapeutic targets

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