The Epigenetic Effects of Coffee

Ding, Qi; Xu, Yan‐Ming; Lau, Andy T. Y.

doi:10.3390/molecules28041770

Cited by 15 publications

(5 citation statements)

References 78 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…When possible, the review listed mechanisms that might explain the relationship of disease comorbidities to AD. Another recent review outlined the health benefits of Coffee Caffeic acid is one of three active ingredients in coffee [226].…”

Section: Discussionmentioning

confidence: 99%

Diet’s Role in Modifying Risk of Alzheimer’s Disease: History and Present Understanding

Grant,

Blake

2023

JAD

View full text Add to dashboard Cite

Diet is an important nonpharmacological risk-modifying factor for Alzheimer’s disease (AD). The approaches used here to assess diet’s role in the risk of AD include multi-country ecological studies, prospective and cross-sectional observational studies, and laboratory studies. Ecological studies have identified fat, meat, and obesity from high-energy diets as important risk factors for AD and reported that AD rates peak about 15–20 years after national dietary changes. Observational studies have compared the Western dietary pattern with those of the Dietary Approaches to Stop Hypertension (DASH), Mediterranean (MedDi), and Mediterranean–DASH Intervention for Neurodegenerative Delay (MIND) diets. Those studies identified AD risk factors including higher consumption of saturated and total fats, meat, and ultraprocessed foods and a lower risk of AD with higher consumption of fruits, legumes, nuts, omega-3 fatty acids, vegetables, and whole grains. Diet-induced factors associated with a significant risk of AD include inflammation, insulin resistance, oxidative stress, elevated homocysteine, dietary advanced glycation end products, and trimethylamine N-oxide. The molecular mechanisms by which dietary bioactive components and specific foods affect risk of AD are discussed. Given most countries’ entrenched food supply systems, the upward trends of AD rates would be hard to reverse. However, for people willing and able, a low–animal product diet with plenty of anti-inflammatory, low–glycemic load foods may be helpful.

show abstract

Section: Discussionmentioning

confidence: 99%

Diet’s Role in Modifying Risk of Alzheimer’s Disease: History and Present Understanding

Grant,

Blake

2023

JAD

View full text Add to dashboard Cite

show abstract

“…Hernandes et al [ 166 ] revealed that CGA restored the CpG hypomethylation status of cancer and then predisposed the cancer cells to its cytotoxic and genotoxic effects [ 166 ]. Ding et al [ 167 ] asserted that CGA modulates gene expression patterns by restoring normal epigenetic signatures such as CpG island DNA methylation, histone post-translational modification, and microRNA expression [ 167 ]. In their investigation of the roles of CGA on epigenetic reprogramming in breast cancer, Lee and Zhu [ 112 ] found that CGA inhibits DNA methyltransferase (DNMT) to prevent hypermethylation of the DNA sequence in both triple negative and triple positive breast cancer cells [ 112 ].…”

Section: Chlorogenic Acid and Cinnamaldehydementioning

confidence: 99%

Natural Compounds and Breast Cancer: Chemo-Preventive and Therapeutic Capabilities of Chlorogenic Acid and Cinnamaldehyde

Olayiwola,

Gollahon

2024

Pharmaceuticals

View full text Add to dashboard Cite

Globally, breast cancer is not only the most frequently diagnosed cancer but also the leading cause of cancer death in women. Depending on breast cancer histotype, conventional breast cancer treatment options vary greatly in efficacy and accompanying side effects. Thus, there is a need for more effective and safer strategies that impact breast cancer at all stages. Plant-based natural products are easily available, with them proving effective and inexpensive. Two such phytochemicals are chlorogenic acid and cinnamaldehyde. Studies have shown their efficacy against different molecular subtypes of breast cancers in vitro and in vivo. In this review, we discuss their current status in anticancer research with specific emphasis on chlorogenic acid and cinnamaldehyde. We describe their multiple mechanisms of action in destroying breast cancer cells, their potential uses, and the need for translational applications. We also include future directions for investigations to progress chlorogenic acid and cinnamaldehyde research from bench to bedside.

show abstract

“…Coffee can impact gene expression via alteration of DNA methylation, histone modificationes and ncRNA expression. Understanding the epigenetic effects is important to finding ways for improving human health (Ding et al 2023).…”

Section: Figure 1 the Repartion Of The Cases According To The Caffee ...mentioning

confidence: 99%

The Coffee Consumption Among Women Over 40 Years Old

Olimid

2023

bihpt

View full text Add to dashboard Cite

The aim of this study was to evaluate the coffee consumption among 204 premenopausal and postmenopausal women. 84.31% of subjects steted that they consume coffee daily, 65.12% of them prefer to add sugar to coffee, 21.51% add sugar and milk and only 13.37% drink black coffee. Regarding the amount consumed daily, 47.67% of women stated that they consume 2 cups of coffee per day, 38.37% consume 1 cups per day and only 13.95% consume 3 or more cups daily. 24.74% of women were smokers. 23.84% of subjects have insomnia if they drink coffee în the afternoon or in the evening. 56.86% of women considered that coffee has benefical effects on health and 38.23% stated that they do no know how to answer.

show abstract

The Epigenetic Effects of Coffee

Cited by 15 publications

References 78 publications

Diet’s Role in Modifying Risk of Alzheimer’s Disease: History and Present Understanding

Diet’s Role in Modifying Risk of Alzheimer’s Disease: History and Present Understanding

Natural Compounds and Breast Cancer: Chemo-Preventive and Therapeutic Capabilities of Chlorogenic Acid and Cinnamaldehyde

The Coffee Consumption Among Women Over 40 Years Old

Contact Info

Product

Resources

About