The epithelial cadherin –160C/A polymorphism is associated with decreased risk of colorectal cancer: a case–control study

Li, Wenhuan; Xiao, Deshuang; Wu, Huawen; Xu, Lewei

doi:10.1007/s10238-019-00586-3

Cited by 2 publications

(4 citation statements)

References 23 publications

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“…In the Caucasian population, the CDH1 polymorphism had significant protective effects on the risk of CRC in four genetic models (OR = 0.91, 95% CI = 0.85-0.98 for the dominant model; OR = 0.93, 95% we also failed to detect any association between the CDH1 polymorphism and any genotyping method. In the stratified analysis by tumor location, six studies 10,13,15,17,19,21 reported the available data and we found that the -160C/A polymorphism may be a protective factor for rectum cancer (heterozygote comparison model: OR = 0.85, 95% CI = 0.77-0.94) (Table 2).…”

Section: Quantitative Synthesismentioning

confidence: 88%

“…As shown in Table 1, there were 16 case-control studies with 8699 CRC cases and 8592 controls concerning the CDH1 polymorphism. [10][11][12][13][14][15][16][17][18][19][20][21][22][23] Ten studies 10,12,13,15,17,[19][20][21][22][23] with 8019 subjects reported the clinical characteristics in the CRC group. The distribution of genotypes in the controls was consistent with HWE for all selected studies except for two studies.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…8 A common polymorphism (CDH1-160C>A; rs16260) of the CDH1 gene promoter region has been reported to have a direct effect on its transcriptional regulation and therefore may influence susceptibility to cancers. 9 Several studies [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25] have investigated associations between CDH1 gene promoter variants and CRC risk. However, the results are inconsistent.…”

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confidence: 99%

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E‐cadherin (CDH1) gene –160C/A polymorphism and the risk of colorectal cancer: A meta‐analysis involving 17,291 subjects

Wang

2021

The Journal of Gene Medicine

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Background: The E-cadherin (CDH1) polymorphism has been implicated in the susceptibility to colorectal cancer (CRC). However, the results remain inconclusive.The present meta-analysis aimed to investigate the association between the CDH1-160C/A polymorphism and CRC risk.Methods: Relevant studies were retrieved by searching PubMed, Web of Science, Google Scholar, the Cochrane Library, Embase, CNKI and Wanfang databases up to 11 March 2021. Pooled odds ratio and 95% confidence interval were calculated using either the fixed-or random-effects model. Quality evaluation was carried out using Newcastle-Ottawa Scale (NOS). A trial sequential analysis (TSA) was conducted to reduce the risk of type I error.Results: In total, 16 studies from 14 articles with 8699 patients and 8592 controls were included. In general, all studies were of high quality (NOS score higher than 6).Overall, no significant associations between the CDH1 -160C/A polymorphism and CRC risk were detected. In subgroup analysis by ethnicity, source of control, genotyping method and location, significant associations were found between the CDH1-160C/A polymorphism and the risk of CRC in the Caucasians and the hospital-based subgroup. Furthermore, 10 studies with 8019 subjects reported the association between the polymorphism and clinical characteristics in CRC patients, and we found that the CDH1-160C/A polymorphism might show a protective role in the distal CRC subgroup. By TSA, the findings in the present study were based on sufficient evidence in Caucasians, but not in Asians.Conclusions: This meta-analysis suggests that the CDH1-160C/A polymorphism may be an important protective factor for CRC in Caucasians and a hospital-based subgroup. Moreover, the polymorphism show a protective role in the distal CRC group. However, large and well-designed studies are warranted to validate our findings, especially for Asians. K E Y W O R D S CDH1, colorectal cancer, meta-analysis, polymorphism 1 | INTRODUCTION Colorectal cancer (CRC) is one of the most common gastrointestinal tumors worldwide. CRC ranks third in terms of incidence and second in terms of mortality based on the GLOBOCAN 2018. 1 The exact etiology and pathogenesis of CRC remain unclear. Epidemiological studies have demonstrated that some risk factors and interactions between genetic and environmental factors may play important roles

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Section: Quantitative Synthesismentioning

confidence: 88%

Section: Study Characteristicsmentioning

confidence: 99%

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confidence: 99%

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E‐cadherin (CDH1) gene –160C/A polymorphism and the risk of colorectal cancer: A meta‐analysis involving 17,291 subjects

Wang

2021

The Journal of Gene Medicine

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“…Research conducted by He et al also found an association between a decrease in E-cadherin regulation and the final stage and poor prognosis of CRC [23]. Research conducted by Li et al concluded that expression of CDH1 (E-cadherin) patients and CDH1-160C/A polymorphism is associated with the decreased risk of CRC in the Chinese Han population [24]. A similar result of the research conducted by Sun et al, who concluded that CDH1-160C/A polymorphism may become a susceptible predictor for risk of CRC in Caucasians [25].…”

Section: Figure 4: the Intensity Of E-cadherin And N-cadherin Expressionsmentioning

confidence: 97%

Differences in the Expression of β-Catenin Nucleus/Cytoplasm Ratio e-Cadherin and n-Cadherin and Correlation of β-Catenin Cytoplasm and Cadherin in Model of Duke D Stage Colorectal Cancer Cell Line

Winarko

Rahayu

Soeatmadji

et al. 2021

Open Access Maced J Med Sci

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BACKGROUND: β-catenin has a critical role in the homeostasis processes. Wnt/β-catenin signaling mainly involved in the modulation of cancer cell development. AIM: This research aimed to investigate the differences of β-catenin expression observed in the form of nucleus–cytoplasm ratio, the differences of E-cadherin and N-cadherin expressions, and the correlation between N-cadherin and E-cadherin and β-catenin cytoplasm in Dukes D stage colorectal cancer (CRC), which is an advanced stage and has experienced metastasis. MATERIALS AND METHODS: This study followed an experimental research design. The processes of culture manufacturing and subculture preparation of Dukes D stage CRC cell line model were performed before the administration of β-catenin, E-cadherin, and N-cadherin antibodies. The next process was staining using fluorescein-5-isothiocyanate and rhodamine, and observations were performed using a confocal microscope. The number of cells was counted, and the intensity of antibody expression based on the arbitrary unit was measured. RESULTS: There was a significant difference between the expression of β-catenin nucleus and cytoplasm expression (p = 0.00), as well as between E-cadherin expression and N-cadherin expression (p = 0.00). In addition, a correlation also existed between an increased N-cadherin expression and decreased E-cadherin expression and β-catenin cytoplasm in Dukes D stage CRC, but the results were not significant (p = 0.837 and p = 0.108). CONCLUSION: In advanced-stage CRC (Dukes D), the Wnt signaling proved to be active and was characterized by a high expression of β-catenin nucleus, it activates the target gene. Similarly, at the Dukes D stage, N-cadherin expression increased whereas E-cadherin expression decreased in which causing the translocation of β-catenin into the nucleus.

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The epithelial cadherin –160C/A polymorphism is associated with decreased risk of colorectal cancer: a case–control study

Cited by 2 publications

References 23 publications

E‐cadherin (CDH1) gene –160C/A polymorphism and the risk of colorectal cancer: A meta‐analysis involving 17,291 subjects

E‐cadherin (CDH1) gene –160C/A polymorphism and the risk of colorectal cancer: A meta‐analysis involving 17,291 subjects

Differences in the Expression of β-Catenin Nucleus/Cytoplasm Ratio e-Cadherin and n-Cadherin and Correlation of β-Catenin Cytoplasm and Cadherin in Model of Duke D Stage Colorectal Cancer Cell Line

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