The essential roles of Toll-like receptor signaling pathways in sterile inflammatory diseases

Lin, Qi; Li, Mingcai; Fang, Dan; Jia, Fang; Su, Shao Bo

doi:10.1016/j.intimp.2011.04.026

Cited by 90 publications

(82 citation statements)

References 169 publications

(237 reference statements)

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“…Each member binds a conserved subset of pathogen-associated molecule patterns such as triacylated and diacylated lipoproteins (TLR2/1 and TLR2/6), LPS (TLR4), nucleic acids (TLR3, TLR7, TLR8, and TLR9), and flagellin (TLR5) or endogenous damage-associated molecule patterns such as HMGB1 (TLR4) or mitochondrial DNA (TLR9) to induce activation of TLR intracellular signaling pathways (8,9). In particular, TLR2 recognizes a diverse set of triacylated and diacylated microbial lipoproteins present on both Gram-negative and Gram-positive bacteria and forms heterodimers with either TLR1 or TLR6, respectively (10 -12).…”

mentioning

confidence: 99%

ERK5 Protein Promotes, whereas MEK1 Protein Differentially Regulates, the Toll-like Receptor 2 Protein-dependent Activation of Human Endothelial Cells and Monocytes

Wilhelmsen

Mesa

Lucero

et al. 2012

Journal of Biological Chemistry

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mentioning

confidence: 99%

ERK5 Protein Promotes, whereas MEK1 Protein Differentially Regulates, the Toll-like Receptor 2 Protein-dependent Activation of Human Endothelial Cells and Monocytes

Wilhelmsen

Mesa

Lucero

et al. 2012

Journal of Biological Chemistry

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“…In addition, emerging evidence suggests that innate immunity drives the development of ALD and that interferon regulatory factor 3 (IRF3), a transcription factor that regulates innate immune responses, is indispensable for the development of this disease (Petrasek et al 2013). TLRs are key molecules of the innate immune system that play a major role in mediating inflammatory processes by promoting the production of several circulating inflammatory molecules, including cytokines, chemokines, and other molecules that participate in tissue repair or exacerbate tissue damage in several diseases (Lin et al 2011). Patients with stable, chronic ALD exhibit attenuation of the TLR2-mediated innate immune responses in peripheral blood monocytes (Pimentel-Nunes et al 2010).…”

Section: Discussionmentioning

confidence: 99%

Association between circulating inflammatory molecules and alcoholic liver disease in men

Jia³

et al. 2016

Cell Stress and Chaperones

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The association between alcoholic liver disease (ALD) and the inflammatory response remains controversial. The aim of this study was to explore this association between ALD and inflammation. We enrolled 214 male participants, who were divided into three age-matched groups: ALD (n = 135), chronic alcohol ingestion without ALD (non-ALD; n = 42), and control (n = 37). The BMI was significantly higher in the ALD group than in the non-ALD and control groups (all P = 0.000). Further, the constituent ratio of the liver inflammatory level was significantly higher in the ALD group than in the non-ALD and control groups (P = 0.002 and P = 0.000, respectively). In addition, the median serum ALT, AST, and GGT levels were significantly higher in the ALD group than in the control group (P = 0.023, P = 0.008, and P = 0.000, respectively); these levels were also significantly higher in the ALD group than in the non-ALD group (P = 0.013, P = 0.010, and P = 0.000, respectively). The median serum CRP level was significantly higher in the ALD group than in the non-ALD and control groups (P = 0.006 and P = 0.000, respectively). Further, the median serum TNF-α level was significantly lower in the ALD group than in the non-ALD and control groups (P = 0.004 and P = 0.000, respectively). The median serum sOX40L and HSP70 levels were significantly lower in the ALD group than in the control group (P = 0.008 and P = 0.018, respectively). In addition, the ALT, AST, and GGT levels were positively correlated with the CRP level (r = 0.211, P = 0.002; r = 0.220, P = 0.001 and r = 0.295, P = 0.000, respectively), and the GGT level was negatively correlated with the TNF-α (r = −0.225, P = 0.001), sOX40L (r = −0.165, P = 0.016), and HSP70 levels (r = −0.178, P = 0.009). Further, the Cr level was negatively correlated with the IL-10 level (r = −0.166, P = 0.015). Logistic regression analysis verified that the BMI (OR = 1.637, 95%CI: 1.374-1.951, P = 0.000) and GGT level were significantly higher (OR = 1.039, 95%CI: 1.020-1.059, P = 0.000) and that the TNF-α (OR = 0.998, 95%CI: 0.996-1.000, P = 0.030) and HSP70 levels were significantly lower (OR = 1.017, 95%CI: 1.003-1.031, P = 0.029) in the ALD group than in the non-ALD group. Further, the moderate-to-severe ALD patients had a significantly higher serum CRP level (Or = 1.349, 95%CI: 1.066-1.702, P = 0.013) and significantly lower HSP60 (OR = 0.965, 95%CI: 0.938-0.993, P = 0.014) and HSP70 levels (OR = 0.978, 95%CI: 0.962-0.995, P = 0.010) than the mild ALD patients. These results suggest that ALD patients may present with obesity, liver damage, and an imbalanced inflammatory immune response, mainly manifesting as decreased levels of immune inflammatory cytokines. In addition, they suggest that certain liver and kidney function parameters and ALD severity are either positively or negatively correlated with certain inflammatory cytokines. Hence, ALD patients may be at increased risks of obesity-and inflammation-related diseases. Accordingly, to control the inflammatory response, preventativ...

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“…A molécula adaptadora MyD88 faz parte da cascata de sinalização de todos os TLRs, exceto o TLR3 (LIN et al, 2011). Assim sendo, a cascata de sinais mediada por MyD88 está associada com a ativação induzida por estes receptores durante a resposta inata.…”

Section: Discussionunclassified

Potencial da migalina (Acilpoliamina) como agente imunomodulador das funções de macrófagos murinos.

Nassar¹

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The essential roles of Toll-like receptor signaling pathways in sterile inflammatory diseases

Cited by 90 publications

References 169 publications

ERK5 Protein Promotes, whereas MEK1 Protein Differentially Regulates, the Toll-like Receptor 2 Protein-dependent Activation of Human Endothelial Cells and Monocytes

ERK5 Protein Promotes, whereas MEK1 Protein Differentially Regulates, the Toll-like Receptor 2 Protein-dependent Activation of Human Endothelial Cells and Monocytes

Association between circulating inflammatory molecules and alcoholic liver disease in men

Potencial da migalina (Acilpoliamina) como agente imunomodulador das funções de macrófagos murinos.

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