The Establishment of an In Vivo HIV-1 Infection Model in Humanized B-NSG Mice

Fan, Tianjiao; Sun, Li; Yang, Xianguang; Jin, Xia; Sun, Wei‐Zen; Wang, Jianhua

doi:10.1007/s12250-019-00181-6

Cited by 3 publications

(3 citation statements)

References 32 publications

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“…Enhancing innate immune activation along with enduring antigen-specific Th1 responses and Th17 responses via STING -activating adjuvants could be desirable in TB/HIV coinfection vaccine design. While a number of studies report characterization of successful Mtb/HIV coinfection mouse model 37,[47][48][49] , it remains largely unsuitable to study the HIV coinfection induced reactivation of a latent TB infection (LTBI). In addition, the mouse model is limited in terms of reliability as an efficient evaluation system for longterm protective immune responses.…”

Section: Mouse Model In Tb/hiv Vaccinesmentioning

confidence: 99%

“…While a number of studies report characterization of successful Mtb /HIV coinfection mouse model 37 , 47 – 49 , it remains largely unsuitable to study the HIV coinfection induced reactivation of a latent TB infection (LTBI). In addition, the mouse model is limited in terms of reliability as an efficient evaluation system for long-term protective immune responses.…”

Section: Mouse Model In Tb/hiv Vaccinesmentioning

confidence: 99%

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Vaccine strategies for the Mtb/HIV copandemic

Sharan

Kaushal

2020

npj Vaccines

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One-third of world’s population is predicted to be infected with tuberculosis (TB). The resurgence of this deadly disease has been inflamed by comorbidity with human immunodeficiency virus (HIV). The risk of TB in people living with HIV (PLWH) is 15–22 times higher than people without HIV. Development of a single vaccine to combat both diseases is an ardent but tenable ambition. Studies have focused on the induction of specific humoral and cellular immune responses against HIV-1 following recombinant BCG (rBCG) expressing HIV-1 antigens. Recent advances in the TB vaccines led to the development of promising candidates such as MTBVAC, the BCG revaccination approach, H4:IC31, H56:IC31, M72/AS01 and more recently, intravenous (IV) BCG. Modification of these vaccine candidates against TB/HIV coinfection could reveal key correlates of protection in a representative animal model. This review discusses the (i) potential TB vaccine candidates that can be exploited for use as a dual vaccine against TB/HIV copandemic (ii) progress made in the realm of TB/HIV dual vaccine candidates in small animal model, NHP model, and human clinical trials (iii) the failures and promising targets for a successful vaccine strategy while delineating the correlates of vaccine-induced protection.

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Section: Mouse Model In Tb/hiv Vaccinesmentioning

confidence: 99%

Section: Mouse Model In Tb/hiv Vaccinesmentioning

confidence: 99%

Vaccine strategies for the Mtb/HIV copandemic

Sharan

Kaushal

2020

npj Vaccines

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“…Retroviruses (family Retroviridae) have great medical and economic significance, as some are associated with severe infectious disease or are oncogenic (1)(2)(3)(4)(5). Retroviruses are notable as they occasionally integrate into the germline of a host and become endogenous retroviruses (ERVs), which can be vertically inherited (6,7).…”

Section: Introductionmentioning

confidence: 99%

Multiple infiltration and cross-species transmission of foamy viruses across Paleozoic to Cenozoic era

Chen

Zhang

Wei

et al. 2020

Preprint

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Foamy viruses (FVs) are complex retroviruses that can infect humans and other animals. In this study, by integrating transcriptomic and genomic data, we discovered 412 FVs from 6 lineages in amphibians, which significantly increased the known set of FVs in amphibians. Among these lineages, salamander FVs maintained a co-evolutionary pattern with their hosts that could be dated back to the Paleozoic era, while, on the contrary, frog FVs were much more likely acquired from cross-species (class level) transmission in the Cenozoic era. In addition, we found three distinct FV lineages had integrated into the genome of a salamander. Unexpectedly, we identified a potential exogenous form of FV circulated in caecilian, demonstrating the existence of exogenous form of FV besides mammals. Our discovery of rare phenomena in amphibian FVs has overturned our collective understanding of the macroevolution of the complex retrovirus.ImportanceFoamy viruses (FVs) represent, more so than other viruses, the best model of co-evolution between a virus and a host. This study represents so far, the largest investigation of amphibian FVs and revealed 412 FVs of 6 distinct lineages from three major orders of amphibians. Besides co-evolutionary pattern, cross-species and repeated infection were also observed during evolution of amphibian FVs. Remarkably, expressed FVs including a potential exogenous form were discovered, suggesting live FVs could be underestimated in nature. These findings revealed the multiple origin and complex evolution of amphibian FVs started from the Paleozoic era.

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Tuberculosis meningitis coexisting with HIV Infection: a comprehensive review

Navasardyan,

Abdou,

Kades

et al. 2023

Front. Tuberc

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Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis (TB) in humans, Although Mtb is primarily considered a respiratory pathogen, its ability to spread to and affect the central nervous system (CNS) is of particular interest due to its clinical importance. Tuberculosis meningitis (TBM) is described as the manifestation of Mtb infection in the meninges, leading to inflammation and disease. Individuals with a weakened immune system, particularly those infected with human immunodeficiency virus (HIV), are more susceptible to both pulmonary and extrapulmonary Mtb infection. HIV infection leads to a gradual depletion of CD4 T-cells, severely impairing the host's immune response against pathogens and, thus, predisposes one to several opportunistic infections, including Mtb. Herein, we discuss the current knowledge, potential therapeutic agents, and mechanisms of action and describe various in vivo and in vitro models that may be used to study TBM coexisting with HIV infection.

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The Establishment of an In Vivo HIV-1 Infection Model in Humanized B-NSG Mice

Cited by 3 publications

References 32 publications

Vaccine strategies for the Mtb/HIV copandemic

Vaccine strategies for the Mtb/HIV copandemic

Multiple infiltration and cross-species transmission of foamy viruses across Paleozoic to Cenozoic era

Tuberculosis meningitis coexisting with HIV Infection: a comprehensive review

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