The ethanolic extract of the Eclipta prostrata L. ameliorates the cognitive impairment in mice induced by scopolamine

Jung, Won Yong; Kim, Haneul; Park, Ho Jae; Jeon, Se Jin; Park, Hye Jin; Choi, Hyung-Seok; Kim, Nam Jae; Jang, Dae Sik; Kim, Dong Hyun; Ryu, Jong Hoon

doi:10.1016/j.jep.2016.06.010

Cited by 28 publications

(5 citation statements)

References 44 publications

(48 reference statements)

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“…It can be speculated that neurotransmitters released by higher dose of ELCM could activate autoreceptors, resulting in the inhibition of the release of relevant neurotransmitters and inhibition of neuronal activities, such as decreased phosphorylation levels of signaling molecules [ 49 ]. Similar inverted U-shaped dose–response patterns have been reported by us and others [ 50 – 52 ]. Further studies are needed to clarify this issue.…”

Section: Discussionsupporting

confidence: 90%

The effects of the ethanol extract of Cordia myxa leaves on the cognitive function in mice

Kendir

Bae

Kim

et al. 2022

BMC Complement Med Ther

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Background Cordia myxa L. (Boraginaceae) is widely distributed in tropical regions and it’s fruits, leaves and stem bark have been utilized in folk medicine for treating trypanosomiasis caused by Trypanosoma cruzi. A population-based study showed that T. cruzi infection is associated with cognitive impairments. Therefore, if C. myxa has ameliorating activities on cognitive function, it would be useful for both T. cruzi infection and cognitive impairments. Methods In this study, we evaluated the effects of an ethanol extract of leaves of C. myxa (ELCM) on memory impairments and sensorimotor gating deficits in mice. The phosphorylation level of protein was observed by the Western blot analysis. Results The administration of ELCM significantly attenuated scopolamine-induced cognitive dysfunction in mice, as measured by passive avoidance test and novel object recognition test. Additionally, in the acoustic startle response test, we observed that the administration of ELCM ameliorated MK-801-induced prepulse inhibition deficits. We found that these behavioral outcomes were related with increased levels of phosphorylation phosphatidylinositol 3-kinase (PI3K), protein kinase B (Akt) and glycogen synthase kinase 3 beta (GSK-3β) in the cortex and extracellular signal-regulated kinase (ERK) and cAMP response element-binding protein (CREB) in the hippocampus by western blot analysis. Conclusions These results suggest that ELCM would be a potential candidate for treating cognitive dysfunction and sensorimotor gating deficits observed in individuals with neurodegenerative diseases.

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Section: Discussionsupporting

confidence: 90%

The effects of the ethanol extract of Cordia myxa leaves on the cognitive function in mice

Kendir

Bae

Kim

et al. 2022

BMC Complement Med Ther

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“…A major factor in age-related senile central nervous system dysfunction and the early stages of AD may be a disruption in the cholinergic neurotransmission system [ 37 ]. Scopolamine is a non-selective muscarinic acetylcholine receptor antagonist and it has been reported to be associated with learning and memory impairments by inhibition of the cholinergic system in the central nervous system [ 38 ]. Thus, in order to explore the possible mechanisms of memory-enhancing effects of SI in SCOP-treated mice, the change of cholinergic system was evaluated.…”

Section: Discussionmentioning

confidence: 99%

Neuroprotective Effects of Soy Isoflavones on Scopolamine-Induced Amnesia in Mice

Lü

Wang

et al. 2018

Nutrients

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In the recent years, interest in soybean as a neuroprotective nutrient in the management of Alzheimer’s disease (AD) has increased and soy isoflavones (SI), as kinds of soybean phytochemicals, are thought to be biologically active components that confer this beneficial effect against neurodegenerative diseases. However, the neuroprotective effect of SI is not well understood. Therefore, the present study (30 days) was conducted to investigate the neuroprotective effects of soy isoflavones (SI) on scopolamine (SCOP)-induced memory impairments in Institute of Cancer Research (ICR) mice (aged 4 weeks) and to elucidate its underlying mechanisms of action. SI (40 mg/kg) administration improved the cognitive performance of SCOP-treated mice in an object location recognition task and the Morris water maze test. SI (40 mg/kg) administration significantly enhanced cholinergic system function and suppressed oxidative stress levels in the hippocampus of SCOP-treated mice. Furthermore, SI (40 mg/kg) treatment markedly upregulated the phosphorylation levels of extracellular signal-regulated kinase (ERK), cAMP response element-binding protein (CREB) and brain-derived neurotrophic factor (BDNF) expression levels in the hippocampus. Taken together, these results demonstrated that soy isoflavones exerted a significant neuroprotective effect on cognitive dysfunctions induced by scopolamine, suggesting that soy isoflavones could be a good candidate for possible treatment of neurodegenerative diseases, such as Alzheimer’s disease (AD).

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“…The two chambers were separated by a guillotine door (5 × 5 cm 2 ). The floor of the non-illuminated compartment was composed of 2-mm stainless steel rods spaced 1 cm apart and connected with an electric grid as described previously (Jung et al 2016). Mice were administered with PAF-EA (100 or 200 mg/kg, p.o.)…”

Section: Passive Avoidance Testmentioning

confidence: 99%

HO-1 dependent antioxidant effects of ethyl acetate fraction from Physalis alkekengi fruit ameliorates scopolamine-induced cognitive impairments

Moniruzzaman

Chin

Cho

2018

Cell Stress and Chaperones

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Physalis alkekengi var. francheti is an indigenous herb well known for its anti-inflammatory, sedative, antipyretic, and expectorant properties. However, the information regarding the impacts of P. alkekengi fruits (PAF) in modulation of oxidative stress and learning memory are still unknown. This study therefore evaluated the antioxidant properties of ethyl acetate (EA) fraction of PAF and its impacts on learning and memory. The antioxidant activities of PAF were evaluated in LPS-induced BV2 microglial cells. The potent EA fraction then investigated and confirmed for its involvement of HO-1 pathway using hemin (HO-1 inducer) and ZnPP (HO-1 inhibitor) through Western blotting, DCFH-DA, and/or Griess assay. The involvements of PI3K/Akt, MEK, and p38 MAPK also investigated. Furthermore, we applied EA fraction to the animals at 100 and 200 mg/kg doses to check if the extract could improve scopolamine-induced memory deficits in passive avoidance and elevated plus maze tests. Our results demonstrated that the fractions from PAF significantly inhibited the generation of intracellular reactive oxygen species (ROS) induced by LPS in concentration-dependent manners. In comparison to other fractions, the EA fraction exhibited potent effect in suppressing intracellular ROS generation. Besides, EA fraction also induced the expression of HO-1 in time-and concentrationdependent manners. ZnPP significantly reversed the suppressive effect of EA fraction on LPS-induced ROS generation and NO production, which confirm the involvement of HO-1 signaling in EA-fraction-mediated antioxidant activities. Consistently, blocking of PI3K/Akt, MEK, and p38 MAPK pathways by PAF-EA suppressed the production of intracellular ROS, indicating their potential participation. In addition, one of the major constituents of EA fraction, luteolin-7-O-β-D-glucoside, also demonstrated HO-1-dependent antioxidant effects in BV2 cells. Further, the EA fraction significantly (p < 0.05) improves scopolamineinduced memory deficits in mice. Taken together, our findings highlight the antioxidant effects of EA fraction of PAF which may be beneficial in treatment of different neurodegenerative diseases associated with free radicals.

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The ethanolic extract of the Eclipta prostrata L. ameliorates the cognitive impairment in mice induced by scopolamine

Cited by 28 publications

References 44 publications

The effects of the ethanol extract of Cordia myxa leaves on the cognitive function in mice

The effects of the ethanol extract of Cordia myxa leaves on the cognitive function in mice

Neuroprotective Effects of Soy Isoflavones on Scopolamine-Induced Amnesia in Mice

HO-1 dependent antioxidant effects of ethyl acetate fraction from Physalis alkekengi fruit ameliorates scopolamine-induced cognitive impairments

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