The etiologies of sperm DNA abnormalities in male infertility: An assessment and review

Pourmasumi, Soheila; Sabeti, Parvin; Rahiminia, Tahereh; Mangoli, Esmat; Tabibnejad, Nasim; Talebi, Ali Reza

doi:10.29252/ijrm.15.6.331

Cited by 62 publications

(45 citation statements)

References 150 publications

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“…Different factors, especially leukocytospermia ( 60 , 61 ), smoking, obesity and other lifestyles ( 62 – 64 ), age ( 65 , 66 ), male accessory gland infections ( 67 ), varicocele ( 68 ), and neoplastic diseases ( 69 – 72 ), may be correlated with increased sperm DNA damage, with a consequent impact on male fertility. Iatrogenic causes, above all the chemo- and radiotherapies used to treat cancer, can also have effects on spermatogenesis and consequently on the sperm chromatin ( 43 , 73 , 74 ) (Figure 1 ).…”

Section: Introductionmentioning

confidence: 99%

Fatherhood and Sperm DNA Damage in Testicular Cancer Patients

et al. 2018

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Testicular cancer (TC) is one of the most treatable of all malignancies and the management of the quality of life of these patients is increasingly important, especially with regard to their sexuality and fertility. Survivors must overcome anxiety and fears about reduced fertility and possible pregnancy-related risks as well as health effects in offspring. There is thus a growing awareness of the need for reproductive counseling of cancer survivors. Studies found a high level of sperm DNA damage in TC patients in comparison with healthy, fertile controls, but no significant difference between these patients and infertile patients. Sperm DNA alterations due to cancer treatment persist from 2 to 5 years after the end of the treatment and may be influenced by both the type of therapy and the stage of the disease. Population studies reported a slightly reduced overall fertility of TC survivors and a more frequent use of ART than the general population, with a success rate of around 50%. Paternity after a diagnosis of cancer is an important issue and reproductive potential is becoming a major quality of life factor. Sperm chromatin instability associated with genome instability is the most important reproductive side effect related to the malignancy or its treatment. Studies investigating the magnitude of this damage could have a considerable translational importance in the management of cancer patients, as they could identify the time needed for the germ cell line to repair nuclear damage and thus produce gametes with a reduced risk for the offspring.

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Section: Introductionmentioning

confidence: 99%

Fatherhood and Sperm DNA Damage in Testicular Cancer Patients

et al. 2018

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“…This cluster had the lowest proportion of men with pus cells of 1 -2/hpf, the highest proportion of those with pus cells of ≥3/hpf and the highest mean pus cells of 5.5 (3.3) among those who had pyospermia of ≥3/hpf. Infection induces reactive oxygen species production, decreases the total antioxidant capacity and sperm DNA fragmentation or antigen production that lead to sperm dysfunctions and DNA fragmentation [18].…”

Section: Discussionmentioning

confidence: 99%

Pyospermia in Men Seeking Assisted Reproduction Technology

Ajayi¹,

Afolabi²,

Ajayi³

et al. 2018

OJU

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Introduction: Pyospermia is often detected in semen, especially when investigating for male infertility. Pyospermia, in a significantly large number is often correlated with inferior sperm parameters and reduced fertility. Pyospermia may be a factor of a fundamental genitourinary infection. This study assessed the relationship between pus cells and semen parameters in infertile Nigerian males. Subjects and Methods: A cross-sectional descriptive study was carried out at Nordica Fertility Center, Lagos, Nigeria, from 2004 to 2009. A total of 907 subjects were analyzed. Subjects ages (years) were categorized into ≤30, BMI into <18.5 (underweight), and ≥30 (obese) and pus cells into none, 1 -2 and ≥3. Results: Leucocytopenia of ≥3 per high power field (/hpf) occurred in 67 (7.4%) men. The overall means (±sd) of pus cells was 1.4 (0.9), 1.4 (0.7), 1.4 (0.7) and 1.6 (1.6) per high power field in all, normospermia, oligoospermic and azoospermic clusters of patients respectively. Mean (±sd) pus cells in semen was 6.0 (4.0), the highest, among obese (BMI ≥ 30) azoospermic patients. The proportion of subjects with pyospermia of 1 -2 was highest (323/346, 93.3%) among oligoospermic patients while that with pyospermia of ≥3 was highest (10/109, 9.2%) among azoospermic patients. Obese azoospermic patients were 1.8 times as likely to have ≥3/hpf pyospermia compared to normal normospermic patients (x² = 0.05, P-value = 0.51, OR = 1.82, 95% CI: 0.30, 11.02). Mean progressive motility (%) was significantly reduced (t = 1.95, P-value = 0.03) among patients with ≥3/hpf pyospermia (33.75 ± 19.23) compared to those with 1 -2/hpf pyospermia (38.58 ± 21.63). Patients with sperm oval head ≤ 30% had significantly higher pyospermia (t = 2.22, P-value = 0.013) than those with sperm oval head of >30%. Conclusion: Elevated pus cell counts were observed among obese

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“…Several external, post-testicular, and intra-testicular factors have been correlated with increased levels of male sperm DNA damage (e.g., diabetes, varicocele, spinal cord injury, cancer and chemotherapy, infections, age, lifestyle, and high temperature) [ 5 ]. The effect of metabolic syndrome (MetS) on semen quality, particularly on sperm DNA integrity, is supported by limited data.…”

Section: Introductionmentioning

confidence: 99%

Impact of body mass index and metabolic syndrome on sperm DNA fragmentation in males from infertile couples: A cross-sectional study from Vietnam

Lê

Nguyen

et al. 2020

Metabolism Open

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Objectives This study investigated the relationship between body mass index (BMI) and metabolic syndrome on sperm DNA fragmentation (SDF) in males from infertile couples. Methods This cross-sectional study was performed from September 2018 to September 2019 at the Hue Center for Reproductive Endocrinology and Infertility (HUECREI), Vietnam. The study included men from couples with at least one year of infertility, who were subjected to semen analysis and SDF assay (Halosperm). We also performed a 2-h oral glucose tolerance test and measured lipidemia. Metabolic syndrome (MetS) was defined based on the NHLBI/AHA-ATP III guidelines. Results The mean age of the patients was 35.26 ± 5.87 years and 53.8% of them had a BMI ≥23.0 kg/m 2 . The DNA fragmentation index was significantly associated with overweight (p = 0.024). Men without MetS had a higher rate of big halos and a lower rate of small halos, no halos, and degraded semen compared to that in men with MetS, but the differences were not significant (p > 0.05). By performing multivariable analysis, we found that the SDF value was significantly different among the two groups with either overweight or normal weight. Conclusion In males from infertile couples with a relatively young mean age, BMI can be an independent indicator for SDF. MetS thus has a significant role in the development of sperm DNA fragmentation, at least in overweight individuals; it should thus be assessed under the scope of BMI, for better/earlier detection of increased SDF.

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The etiologies of sperm DNA abnormalities in male infertility: An assessment and review

Cited by 62 publications

References 150 publications

Fatherhood and Sperm DNA Damage in Testicular Cancer Patients

Fatherhood and Sperm DNA Damage in Testicular Cancer Patients

Pyospermia in Men Seeking Assisted Reproduction Technology

Impact of body mass index and metabolic syndrome on sperm DNA fragmentation in males from infertile couples: A cross-sectional study from Vietnam

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