The evaluation of a biodegradable dental chip containing chlorhexidine in chitosan base as a targeted drug delivery in the management of chronic periodontitis in patients

Jothi, M.V.; Bhat, Kumar M.R.; Pratibha, PK; Kumar, Raj; Bhat, GS

doi:10.1002/ddr.20323

Cited by 2 publications

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“…Clinically, chitosan also has high potential in dental applications, and it has used to repair socket after dental extraction ( Ezoddini-Ardakani, 2011 ). Other research also reported that biodegradable dental chip containing chlorhexidine or thymoquinone was applied for management of chronic periodontitis in patients ( Al-Bayaty et al, 2013 ; Jothi et al, 2009 ).…”

Section: Discussionmentioning

confidence: 99%

In vitroevaluation of osteoprotegerin in chitosan for potential bone defect applications

Jayash

Hashim

Misran

et al. 2016

PeerJ

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BackgroundThe receptor activator of nuclear factor kappa-B (RANK)/RANK ligand/osteoprotegerin (OPG) system plays a critical role in bone remodelling by regulating osteoclast formation and activity. OPG has been used systemically in the treatment of bone diseases. In searching for more effective and safer treatment for bone diseases, we investigated newly formulated OPG-chitosan complexes, which is prepared as a local application for its osteogenic potential to remediate bone defects.MethodsWe examined high, medium and low molecular weights of chitosan combined with OPG. The cytotoxicity of OPG in chitosan and its proliferation in vitro was evaluated using normal, human periodontal ligament (NHPL) fibroblasts in 2D and 3D cell culture. The cytotoxicity of these combinations was compared by measuring cell survival with a tetrazolium salt reduction (MTT) assay and AlamarBlue assay. The cellular morphological changes were observed under an inverted microscope. A propidium iodide and acridine orange double-staining assay was used to evaluate the morphology and quantify the viable and nonviable cells. The expression level of osteopontin and osteocalcin protein in treated normal human osteoblast cells was evaluated by using Western blot.ResultsThe results demonstrated that OPG in combination with chitosan was non-toxic, and OPG combined with low molecular weight chitosan has the most significant effect on NHPL fibroblasts and stimulates proliferation of cells over the period of treatment.

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Section: Discussionmentioning

confidence: 99%

In vitroevaluation of osteoprotegerin in chitosan for potential bone defect applications

Jayash

Hashim

Misran

et al. 2016

PeerJ

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“…[ 20 ] revealed that a chitosan concentration of 3% w/w could offer a base for an optimum modulation in drug dose, and make them efficient to use as a local drug delivery agent. According to Jothi et al .,[ 21 ] the local drug delivery system using chlorhexidine with chitosan base polymer reported reduction in probing depths and gain in clinical attachment levels and concluded that chitosan-loaded drugs can be an alternative treatment modality for patients with chronic periodontitis in recall intervals.…”

Section: A Pplications Of C Hitosan In P Eriodonticsmentioning

confidence: 99%

An Overview of Chitosan and Its Role in Periodontics

Thangavelu

Stelin

Vannala

et al. 2021

Journal of Pharmacy and Bioallied Sciences

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Chitosan is a biopolymer with numerous biological properties such as antibacterial, anti-inflammatory, and wound healing. Chitosan also stimulates cell proliferation and osteogenesis and thus used as a scaffold material in tissue engineering. The physical proprieties of chitosan such as biocompatibility and biodegradability give promising results in periodontal therapies. This review gives an updated explanation of the applications of chitosan in dentistry and periodontics. Furthermore, the review demonstrates the actions of chitosan in detail and its role in the regeneration of periodontal structures.

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The evaluation of a biodegradable dental chip containing chlorhexidine in chitosan base as a targeted drug delivery in the management of chronic periodontitis in patients

Cited by 2 publications

References 0 publications

In vitroevaluation of osteoprotegerin in chitosan for potential bone defect applications

In vitroevaluation of osteoprotegerin in chitosan for potential bone defect applications

An Overview of Chitosan and Its Role in Periodontics

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