The evaluation of healing effect of triclosan and flurbiprofen-loaded nanogels in experimental periodontitis in rats by morphometric analysis

Aminu, Nafiu; Yam, Mun-Fei; Chan, Siok-Yee; Bello, Isabelle Cenci di; Umar, Nura Muhammad; Tanko, Nuhu; Toh, Seok-Ming

doi:10.1016/j.sdentj.2020.08.008

Cited by 7 publications

(5 citation statements)

References 21 publications

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“…Micelles released the cargo faster in acidic environments and demonstrated excellent antimicrobial ability against S. aureus and E. coli. Significant regeneration of the lost bone was revealed for the nanogels-treated group as per another study [55] based on morphometric findings. The developed nano-gel system, loaded with antimicrobial TCS and anti-inflammatory FLB (flurbiprofen-loaded nanogels), showed a superior healing effect in treating periodontitis based on the overall results.…”

Section: Drug Deliverysupporting

confidence: 53%

Application of nanotechnology in periodontal therapy: Narrative review

Boitsaniuk,

Levkiv,

Kochan

2024

Charact. Appl. Nanomater.

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The potential of nanotechnology to improve human health, optimize natural resource utilization, and reduce environmental pollution is remarkable. With the ever-growing advancement in dentistry, one of the breakthroughs is using nanotechnology. Nanotechnology in periodontics has touched every aspect of treatment modality, from non-surgical therapy to implant procedures, including regenerative procedures. Understanding of their mechanism plays a pivotal role in more efficient usage of nanotechnology, better treatment procedures, and eventually better outcomes. In this paper we review the application of nanotechnology in periodontal therapy. We performed the search for papers in Scopus using the key words and phrases as follows: “nanodentistry”; “dentistry and nanotechnology”; “dentistry and nanoparticles”; “dentistry and nanomedicine”; “dentistry and nanorobots”. There were found 530 papers in total. Some papers belonged to two and more categories. It is revealed that the number of papers versus year does not follow any specific pattern, but the cumulative amount of papers versus year is fitted with the exponential regression. There were also selected papers using certain inclusion/exclusion criteria. Only the selected papers were analyzed. Nanomedicine is subjected to intensive studies nowadays. There are some promising results that will likely be implemented into praxis soon in the fields of medical diagnostics and clinical therapeutics. The appearance of nanotechnology can have a considerable impact on treatment of periodontal diseases.

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Section: Drug Deliverysupporting

confidence: 53%

Application of nanotechnology in periodontal therapy: Narrative review

Boitsaniuk,

Levkiv,

Kochan

2024

Charact. Appl. Nanomater.

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“…The flow rate was 1.0 mL/min, the injection volume was 10 µL at 25 • C, and the elution of CZP from the HPLC column was monitored by UV absorption at 234 nm for 10 min. Different dilutions of CZP in artificial saliva or water (20,50,80,110,140, and 170 µM) were used to develop a concentration curve using the measured absorbance and areas. The curve allowed for CZP quantification in different samples, and the loading efficiency and release profile were calculated.…”

Section: High-performance Liquid Chromatographymentioning

confidence: 99%

“…There are a few reports on nanogels for local use in the oral cavity, including their use for remineralization in dental caries processes [ 18 , 19 ] and the management of periodontal disease [ 20 ]; furthermore, there are many aspects that remain unknown. Therefore, this study aimed to develop and characterize a novel gelatin-based nanogel delivery system loaded with CZP that has not been reported previously, and evaluate its ability to modulate TRPV1 channels in an in vitro oral cell model as a potential therapeutic strategy for dental pain management.…”

Section: Introductionmentioning

confidence: 99%

Modulation of TRPV1 on Odontoblast-like Cells Using Capsazepine-Loaded Nanogels

Bernal-Cepeda,

Jiménez,

Velandia-Romero

et al. 2024

Pharmaceutics

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The modulation of TRPV1 emerges as a promising strategy for dental pain management. This study aimed to assess TRPV1 modulation in a human odontoblast-like cell model using Capsazepine (CZP) loaded in a nanogel delivery system. Gelatin nanogels, synthesized via the emulsification-gelation technique, were characterized and loaded with the TRPV1 antagonist, CZP. HPLC determined a remarkable 67.5 ± 0.04% CZP loading efficiency, with 71.7% of nanogels falling within the 300–950 nm size range, as evidenced by light microscopy. Moreover, CZP-loaded nanogels had a low cytotoxicity. An FTIR analysis showed no adverse chemical interactions, ensuring stability and active release. When examining biological responses, TRPV1 expression and channel activity were assessed in odontoblast-like cells. On the fifth day post-treatment, cells treated with CZP-loaded nanogels exhibited an increased TRPV1 expression and a reduction in calcium fluxes after agonist stimulus (F/F0 ratio 1.18 ± 0.18), resembling the response in free CZP-treated cells (1.28 ± 0.15). A two-way analysis of variance and the Tukey’s test were used to determine statistical significance (p < 0.05). This delivery system, proven to be economical and straightforward, holds promise for dental pain management and potential local use. Local administration minimizes systemic adverse effects, making it a practical solution for releasing molecules in the oral cavity.

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“…The results suggest that an oral hygiene regimen including a TCS/copolymer/fluoride dentifrice may sustain the short-term effect of non-surgical periodontal therapy in smokers. A recent study on rats demonstrated the therapeutic effectiveness of TCS and an anti-inflammatory flurbiprofen-loaded nanogels system in ligature-induced experimental periodontitis in rats [ 97 ]. TCS activity in periodontitis is related to the activation of human periodontal ligament fibroblasts that are induced by lipopolysaccharide from Porphyromonas gingivalis [ 98 ].…”

Section: Studies On Toothpastes Containing Tcsmentioning

confidence: 99%

Triclosan: A Small Molecule with Controversial Roles

et al. 2022

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Triclosan (TCS), a broad-spectrum antimicrobial agent, has been widely used in personal care products, medical products, plastic cutting boards, and food storage containers. Colgate Total® toothpaste, containing 10 mM TCS, is effective in controlling biofilm formation and maintaining gingival health. Given its broad usage, TCS is present ubiquitously in the environment. Given its strong lipophilicity and accumulation ability in organisms, it is potentially harmful to biohealth. Several reports suggest the toxicity of this compound, which is inserted in the class of endocrine disrupting chemicals (EDCs). In September 2016, TCS was banned by the U.S. Food and Drug Administration (FDA) and the European Union in soap products. Despite these problems, its application in personal care products within certain limits is still allowed. Today, it is still unclear whether TCS is truly toxic to mammals and the adverse effects of continuous, long-term, and low concentration exposure remain unknown. Indeed, some recent reports suggest the use of TCS as a repositioned drug for cancer treatment and cutaneous leishmaniasis. In this scenario it is necessary to investigate the advantages and disadvantages of TCS, to understand whether its use is advisable or not. This review intends to highlight the pros and cons that are associated with the use of TCS in humans.

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The evaluation of healing effect of triclosan and flurbiprofen-loaded nanogels in experimental periodontitis in rats by morphometric analysis

Cited by 7 publications

References 21 publications

Application of nanotechnology in periodontal therapy: Narrative review

Application of nanotechnology in periodontal therapy: Narrative review

Modulation of TRPV1 on Odontoblast-like Cells Using Capsazepine-Loaded Nanogels

Triclosan: A Small Molecule with Controversial Roles

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