The Evaluation of Hemodynamic Changes During the Reperfusion Phase in Adult Living Donor Liver Transplantations: The Role of Cardiovascular Problems

Ayhan, Asude; Araz, Çoşkun; Kömürcü, Özgür; Kaplan, Şerife; Haberal, Mehmet

doi:10.1016/j.transproceed.2015.03.002

Cited by 3 publications

(3 citation statements)

References 8 publications

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“…Prevention of hyperlipidemia and other metabolic disorders can decrease cardiovascular complications and improve the long term outcomes. Liver transplant is considered a coronary heart disease high risk based on the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults [ 4 ]. The study aims to compare the different use of glucocorticoid and the impact on liver function and hyperlipidemia after liver transplantation.…”

Section: Introductionmentioning

confidence: 99%

The Hyperlipidemia Caused by Overuse of Glucocorticoid after Liver Transplantation and the Immune Adjustment Strategy

Meng

Chen

et al. 2017

Journal of Immunology Research

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The overuse of glucocorticoid may cause the metabolic disorders affecting the long term outcome of liver transplantation. This study aims to investigate the immune adjustment strategy by decreasing use of glucocorticoid after liver transplantation. The follow-up study was carried out on liver function and lipid metabolism. This study included adult recipients of liver transplantation. There were 3 groups according to their use of glucocorticoid: long term (>3 months, n = 18), short term (<3 months, n = 20), and control group (no use of glucocorticoid, radical hepatic resection, n = 22). The laboratory results of liver function (AST/ALT ratio) and serum lipid were compared 6 months after liver transplantation. AST/ALT ratio, the marker of liver function, showed no significant difference between long and short term group (P > 0.05). The acute rejection had no significant difference between short and long term groups, while TG, HDL, LDL, and glucose showed significant change in the long term group (P < 0.05). At 6 months after liver transplantation, the long term group showed higher metabolic disorders (P < 0.05). The proper immune adjustment strategy should be made to avoid overuse of glucocorticoid. It can decrease hyperlipidemia and other metabolic disorders after liver transplantation without increasing the acute rejection or liver function damage.

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Section: Introductionmentioning

confidence: 99%

The Hyperlipidemia Caused by Overuse of Glucocorticoid after Liver Transplantation and the Immune Adjustment Strategy

Meng

Chen

et al. 2017

Journal of Immunology Research

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“…The etiology of PRS is complex and multifactorial. Pathophysiology of the hemodynamic instability could be related to deceases in preload, afterload, myocardial contractility of either/both ventricles or rate and/or rhythm changes [4]. These cardiovascular alterations result from a complex phenomenon possibly related to sudden release of cold, acidotic, and hyperkalemic preservation fluid along with vasoactive mediators into the circulation [5].…”

Section: Discussionmentioning

confidence: 99%

“…The causes of this spectrum of hemodynamic instability are multifactorial and complex. They include the sudden release of cold, acidotic, hyperkalemic preservation fluid along with vasoactive mediators into the systemic circulation, surgical anastomotic mishaps with accompanying blood loss and air embolism causing right ventricular outflow tract obstruction and failure [2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Graft reperfusion of transplanted liver–perfect storm for coronary vasospasm

Hebbar¹,

Nelson²,

Kottkamp³

et al. 2016

Liver Pancreat Sci

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Major adverse cardiac events in patients during liver transplantation are due to preexisting cardiopulmonary comorbidities and the impact of surgery on hemodynamics. Graft reperfusion of the transplanted liver is the most hemodynamically critical phase and can be associated with air embolism and the release of acidotic, cold, hyperkalemic effluent containing vaso-constrictive chemical mediators such endothelin-1 and thromboxane A2. Concomitant release of oxygen reactive species can further sensitize the coronary vasculature to vasoconstrictors creating the perfect milieu for coronary vasospasm. We report a case in which myocardial ischemia accompanied by significant ST depression followed reperfusion possibly caused by coronary vasospasm.

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Intraoperative management and early post-operative outcomes of patients with coronary artery disease who underwent orthotopic liver transplantation

Kong

Zhao

Wang

2020

Hepatobiliary & Pancreatic Diseases International

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The Evaluation of Hemodynamic Changes During the Reperfusion Phase in Adult Living Donor Liver Transplantations: The Role of Cardiovascular Problems

Cited by 3 publications

References 8 publications

The Hyperlipidemia Caused by Overuse of Glucocorticoid after Liver Transplantation and the Immune Adjustment Strategy

The Hyperlipidemia Caused by Overuse of Glucocorticoid after Liver Transplantation and the Immune Adjustment Strategy

Graft reperfusion of transplanted liver–perfect storm for coronary vasospasm

Intraoperative management and early post-operative outcomes of patients with coronary artery disease who underwent orthotopic liver transplantation

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