The evaluation of non‐invasive multi‐slice spiral computed tomography‐based indices for the diagnosis and prognosis prediction of liver cirrhosis

Ling, Feng; Lei, Shu Juan; Zeng, Xin; Wang, Pei Qin; Chen, Ru Tan; Wang, Jian; Sheng, Xia; Shi, Pei Mei; Yuan, Zong Li; Xie, Wei

doi:10.1111/1751-2980.12506

Cited by 6 publications

(2 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several studies using CT and MRI have shown that volumetric analysis of the liver and spleen can be used to differentiate between cirrhotic and non-cirrhotic livers (Supplementary Table 1 ) [ 22 , 34 , 36 , 49 , 51 , 67 – 69 ]. Torres et al in 1986 reported on morphological volume changes of hepatic segments using CT images of 75 biopsy-proven cirrhotic and 50 control patients with no liver disease.…”

Section: Methodsmentioning

confidence: 99%

“…This is evidenced by data from a large cohort from the United States of 8853 patients undergoing CT colonography or CT for renal donor work-up whereby the mean spleen volume for males and females was 216 ± 100 cm 3 [39]. A summary of studies reporting normal spleen volumes is provided in Supplementary Table 7 [22,24,31,[39][40][41][42][43][44][45][46][47][48][49][50][51][52][53][54][55][56][57]. Such countryspecific thresholds for normal splenic volume remain below the reported splenic volumes for CLD patients with no hepatic fibrosis (Table 2).…”

Section: Thresholds and Normal Rangesmentioning

confidence: 99%

See 1 more Smart Citation

The impact of hepatic and splenic volumetric assessment in imaging for chronic liver disease: a narrative review

Kutaiba,

Chung,

Goodwin

et al. 2024

Insights Imaging

View full text Add to dashboard Cite

Chronic liver disease is responsible for significant morbidity and mortality worldwide. Abdominal computed tomography (CT) and magnetic resonance imaging (MRI) can fully visualise the liver and adjacent structures in the upper abdomen providing a reproducible assessment of the liver and biliary system and can detect features of portal hypertension. Subjective interpretation of CT and MRI in the assessment of liver parenchyma for early and advanced stages of fibrosis (pre-cirrhosis), as well as severity of portal hypertension, is limited. Quantitative and reproducible measurements of hepatic and splenic volumes have been shown to correlate with fibrosis staging, clinical outcomes, and mortality. In this review, we will explore the role of volumetric measurements in relation to diagnosis, assessment of severity and prediction of outcomes in chronic liver disease patients. We conclude that volumetric analysis of the liver and spleen can provide important information in such patients, has the potential to stratify patients’ stage of hepatic fibrosis and disease severity, and can provide critical prognostic information. Critical relevance statement This review highlights the role of volumetric measurements of the liver and spleen using CT and MRI in relation to diagnosis, assessment of severity, and prediction of outcomes in chronic liver disease patients. Key Points Volumetry of the liver and spleen using CT and MRI correlates with hepatic fibrosis stages and cirrhosis. Volumetric measurements correlate with chronic liver disease outcomes. Fully automated methods for volumetry are required for implementation into routine clinical practice. Graphical Abstract

show abstract