The evaluation of platelet indices and markers of inflammation, coagulation and disease progression in treatment‐naïve, asymptomatic <scp>HIV</scp>‐infected individuals

Nkambule, Bongani B.; Davison, Glenda Mary; Ipp, Hayley

doi:10.1111/ijlh.12307

Cited by 24 publications

(27 citation statements)

References 43 publications

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“…Active platelets play a key role in both inflammation and thrombosis. Hematology analyzers measure this activity with different indicators, and MPV is also one of these indicators (21,22). MPV is a cost-effective and cheap parameter showing platelet function and activation, which may be demonstrated in whole blood count and affected by inflammation (23).…”

Section: Resultsmentioning

confidence: 99%

The Significance of Mean Platelet Volume in Acute Pancreatitis

2016

Ann Clin Anal Med

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ÖzetAmaç: Akut pankreatit, önemli komplikasyonlar ve yüksek mortalite ile seyredebilen bir hastalıktır. Pankreasta normalde inaktif halde bulunan sindirim enzimlerinin aktif hale geçerek pankreas dokularını sindirmesi ve buna bağlı ortaya çıkan inflamasyonla karakterize bir hastalıktır. Çalışmamızda; acil servise karın ağrısı şikayeti ile başvurup Akut Pankreatit tanısı alan hastalarda Ortalama Trombosit Hacmi oranlarının seyrini izlemeyi amaçladık. and compared after all patients had been diagnosed with acute pancreatitis and regained good health. Also, the values of mean platelet volume, white blood cells and lipase were recorded twice for these patients. Results: After diagnosis and complete treatment, the mean platelet volume, white blood cells and the lipase values of 116 acute pancreatitis patients were statistically compared it was found that the values on admission were higher than after the treatment. Discussion: Mean platelet volume is an indicator that increases in acute pancreatitis so, we consider that mean platelet volume may be beneficial in the diagnosis and in monitoring the course of acute pancreatitis.

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Section: Resultsmentioning

confidence: 99%

The Significance of Mean Platelet Volume in Acute Pancreatitis

2016

Ann Clin Anal Med

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“…PDW has been considered to be a more reliable marker for distinguishing hyperdestructive thrombocytopenia from hypoproductive thrombocytopenia [24]. In the literature, there are studies showing higher MPV values in patients with HCV or HBV infection, no significant difference in MPV values in acute HBV patients or inactive HBV carriers, decreased MPV levels in HIV patients, and lower PCT values and higher PDW values in patients with HBV infection compared with those in controls [6,7,12,[20][21][22][23]. We consider that platelet indices in our patients may not be significantly affected, in parallel with minimal thrombocytopenia.…”

Section: Discussionmentioning

confidence: 99%

“…In our study, no correlation between serum AST, ALT, or HCV RNA levels and platelet indices was found in young adult male patients with HCV infection. In the literature, decreased MPV levels in HIV patients have been shown to be correlated with PCT, PDW, and viral load [12]. Also, platelet counts and PCT have been reported to be inversely correlated with HBV deoxyribonucleic acid (DNA) levels [25].…”

Section: Discussionmentioning

confidence: 99%

“…MPV levels have been described as a diagnostic or prognostic predictor not only for patients with prothrombotic conditions including obesity, hypercholesterolemia, diabetes, hypertension, smoking, and arterial stiffness, but also for those with proinflammatory conditions including rheumatic diseases or infectious disorders such as sepsis, infective endocarditis, pneumonia, or viral hepatitis [3][4][5][6][7][8][9][10][11]. Also, decreased MPV levels in human immunodeficiency virus (HIV) patients compared with controls have been shown to be correlated with PCT, PDW, and viral load [12]. PDW, an indicator of the variation in platelet size, has also been found significantly higher in non-survivor sepsis patients and has been defined as an independent variable determining the severity of fibrosis [5,8,9].…”

mentioning

confidence: 99%

“…PDW, an indicator of the variation in platelet size, has also been found significantly higher in non-survivor sepsis patients and has been defined as an independent variable determining the severity of fibrosis [5,8,9]. PCT, a reliable parameter of platelet biomass but also the most neglected CBC parameter in clinical practice, is influenced by platelet numbers as well as platelet sizes [8,12,13]. PCT has been reported to be negatively correlated with parasitema in patients with malaria caused by Plasmodium vivax [13].…”

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confidence: 99%

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Evaluation of Platelet Indices in Young Male Patients with Hepatitis C

Afyon¹

2016

Ann Clin Anal Med

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ÖzetAmaç: Hepatit C virüs (HCV) enfeksiyonu olan hastalarda enflamasyon ve fibrozisin şiddetine bağlı olarak platelet sayısı ve boyutlarının değişebileceği gerçeği doğrultusunda, HCV enfeksiyonu olan erkek hastalarda sağlıklı kontrol grubuna kıyasla platelet parametrelerinin ve platelet-lenfosit oranı (PLR) seviyelerini ve önemini araştırmayı amaçladık. Gereç ve Yöntem: 01 Ocak 2012 ve 01 Haziran 2015 tarihleri arasında Enfeksiyon Hastalıkları polikliniğine HCV enfeksiyonu nedeniyle müracaat eden hastaların dosyaları geriye dönük olarak değerlendirildi. Karaciğer biyopsisi olmuş 21 erkek hasta ile cinsiyet ve yaş uyumlu 22 sağlıklı kontrol çalışmaya dahil edildi. İsta-tiksel analizler SPSS 15.0 programı ile yapıldı. Bulgular: Hasta grubu (ortalama yaş=24.62±5.84 yıl ve yaş aralığı=21-41 yıl) ve kontrol grubu (ortalama yaş=24.59±5.21 yıl ve yaş aralığı=21-41 yıl) arasında yaş değişkeni açısından anlamlı farklılık yoktu. Hastaların %23.8'inde fibrozis skoru 1, %61.9'unda fibrozis skoru 2 ve sadece %14.3'ünde fibrozis skoru 3 olarak belirlendi. Kontrol grubuna göre hasta grubunda, lenfosit sayıları, platelet sayıları, PLR, plateletcrit ve platelet hacmi dağılım genişliği düşük ve ortalama platelet hacmi (MPV) daha yüksek olsa da, iki grup arasında istatiksel olarak anlamlı farklı-lık yoktu. Ayrıca, platelet sayıları, platelet parametreleri ve PLR değerleri açı-sından fibrozis skoruna ve histolojik aktivite indeksi skoruna göre hasta grupları arasında da anlamlı farklılık yoktu. Tartışma: Çalışmamız sonucunda HCV enfeksiyonuna bağlı minimal ve orta derecede fibrozisi olan genç yetişkin erkek hastalarda, platelet sayıları, platelet parametreleri ve PLR değerlerinde anlamlı olmayan minimal bir etkilenme tespit edildi. Bununla birlikte, platelet sayılarının daha düşük beklendiği ilerlemiş fibrozisi veya sirozu olan hastalarda, platelet parametrelerinin önemi artabilir. Anahtar KelimelerHepatit C Virüsü; Fibrozis; Platelet Parametreleri; Ortalama Platelet Hacmi; Platelet-Lenfosit Oranı Abstract Aim: In light of the fact that platelet counts and sizes or lymphocyte counts may be altered in patients with hepatitis C virus (HCV) depending upon the severity of inflammation or fibrosis, we aimed to investigate the values and the roles of platelet indices and platelet-to-lymphocyte ratio (PLR) in male patients with HCV infection compared with healthy controls. Material and Method: Patients with HCV infection who applied to an Infectious Diseases clinic between 01 January 2012 and 01 June 2015 were evaluated retrospectively. Overall, 21 male HCV patients who underwent percutaneous liver biopsy and 22 gender-and age-matched healthy controls were included in the study. Statistical analyses were performed by SPSS 15.0. Results: There was no significant difference in age variable between the patients group with an age range of 21-41 years [22 (Iq=4), 24.62±5.84 years] and the control group with an age range of 21-41 years [22,5 (Iq=5), 24.59±5.21 years].

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Development and validation of a prognostic nomogram for HIV/AIDS patients who underwent antiretroviral therapy: Data from a China population-based cohort

et al. 2019

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BackgroundAccurate forecast of the death risk is crucial to the administration of people living with HIV/AIDS (PLHIV). We aimed to establish and validate an effective prognosis nomogram in PLHIV receiving antiretroviral therapy (ART).MethodsAll the data were obtained from 2006 to 2018 in the Wenzhou area from China AIDS prevention and control information system. Factors included in the nomogram were determined by univariate and multiple Cox proportional hazard analysis based on the training set. The receiver operating characteristic (ROC) and calibration curves were used to assess its predictive accuracy and discriminative ability. Its clinical utility was also evaluated using decision curve analysis (DCA), X-tile analysis and Kaplan-Meier curve, respectively in an independent validation set.FindingsIndependent prognostic factors including haemoglobin, viral load and CD4+ T-cell count were determined and contained in the nomogram. Good agreement between the prediction by nomogram and actual observation could be detected in the calibration curve for mortality, especially in the first year. In the training cohort, AUC (95% CI) and C-index (95% CI) were 0.93 (0.90, 0.96) and 0.90 (0.85, 0.96), respectively. In the validation set, the nomogram still revealed excellent discriminations [AUC (95% CI): 0.95 (0.91, 1.00)] and good calibration [C-index (95% CI): 0.92 (0.82–1.00)]. Moreover, DCA also demonstrated that the nomogram was clinical beneficial. Additionally, participants could be classified into three distinct (low, middle and high) risk groups by the nomogram.InterpretationThe nomogram presents accurate and favourable prognostic prediction for PLHIV who underwent ART.FundingThis work was supported by (LGF19H260011), (Y20180201), the (KYQD170301), the Major Project of the Eye Hospital Wenzhou the Major Project of the (YNZD201602). Part of this work was also funded by (81670777) and and (2019R413073). The funders had no roles in study design, data collection, data analysis, interpretation and writing of the report.

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The evaluation of platelet indices and markers of inflammation, coagulation and disease progression in treatment‐naïve, asymptomatic HIV‐infected individuals

Abstract: Platelet indices may offer a rapid and affordable method for monitoring platelet activation and disease progression in patients with HIV.

Cited by 24 publications

References 43 publications

The Significance of Mean Platelet Volume in Acute Pancreatitis

The Significance of Mean Platelet Volume in Acute Pancreatitis

Evaluation of Platelet Indices in Young Male Patients with Hepatitis C

Development and validation of a prognostic nomogram for HIV/AIDS patients who underwent antiretroviral therapy: Data from a China population-based cohort

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