The evaluation of the hypoglycemic effect of soft drink leaf extract of <i>Phyllanthus amarus</i> (Euphorbiaceae) in rats

Adedapo, Adeolu Alex; Ofuegbe, Sunday Oluwaseun

doi:10.1515/jbcpp-2013-0033

Cited by 16 publications

(6 citation statements)

References 32 publications

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“…Hypoglycaemic effects have been reported for some plants that contain flavonoids (Adedapo & Ofuegbe, 2014;Juárez-Reyes et al, 2015;Liu et al, 2014;Zhang et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Investigation of antidiabetic action ofAntidesma buniusextract in type 1 diabetes

El-Tantawy

Soliman

Elnaggar

et al. 2015

Archives of Physiology and Biochemistry

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“…Hypoglycaemic effects have been reported for some plants that contain flavonoids (Adedapo & Ofuegbe, 2014;Juárez-Reyes et al, 2015;Liu et al, 2014;Zhang et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Investigation of antidiabetic action ofAntidesma buniusextract in type 1 diabetes

El-Tantawy

Soliman

Elnaggar

et al. 2015

Archives of Physiology and Biochemistry

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“…Higher sperm count, percentages of sperm forward motility, viability and HOS tail-coiled with lower percentage of abnormal sperm were observed following C. borivilianum root extract treatment to STZ-induced diabetic rats. Administration of the root extract also lower the percentage of sperm with abnormal appearances, and in few occasion, the herbal root extract effect exceeds glibenclamide, a reference anti-diabetic drug [43]. Our findings have further shown that C. borivilianum root extract was able to lower the level of sperm oxidative stress as evident from lower amount of lipid peroxidation product, MDA, tissue superoxide and nitric oxide free radicals and higher amount of total antioxidant capacity (TAC) and levels of endogenous antioxidant enzymes (SOD, CAT and GPx) in the sperm of diabetic rats.…”

Section: Discussionmentioning

confidence: 99%

Chlorophytum borivilianum (Safed Musli) root extract prevents impairment in characteristics and elevation of oxidative stress in sperm of streptozotocin-induced adult male diabetic Wistar rats

Giribabu

Kilari

Rekha

et al. 2014

BMC Complement Altern Med

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BackgroundWe hypothesized that C. borivilianum root, known to improve male reproductive performance, prevents impairment in characteristics, morphology and elevation of oxidative stress in sperm of diabetics. We therefore investigated the effect of aqueous root extract of C. borivilianum on these parameters in diabetic rat model.MethodsC. borivilianum root aqueous extract (250 and 500 mg/kg/day) or glibenclamide (600 μg/kg/day) were administered to streptozotocin (STZ)-induced diabetic male rats for 28 consecutive days. At the end of treatment, animals were sacrificed and sperm were collected. Sperm count and percentages of forward motility, viability, hypoosmotic swelling (HOS) tail-coiled and abnormal sperm were evaluated. Sperm lipid peroxidation product (LPO), hydrogen peroxide (H2O2) and nitric oxide (NO) levels, total antioxidant capacity (TAC), activity levels of endogenous antioxidant enzymes (superoxide dismutase-SOD, catalase-CAT and glutathione peroxidase-GPx), epididymal sperm density, serum fasting blood glucose (FBG) and HbA1c levels were measured. The expression of sperm caspase-3 was assessed. Meanwhile, in-vitro free radical scavenging activity of C. borivilianum root extract was determined and the root extract was analyzed for the presence of bioactive compounds by FTIR spectroscopy.ResultsC. borivilianum root aqueous extract prevents the decrease in sperm count, percentages of forward motility, viability, HOS and the increase in abnormal sperm percentage and caspase-3 level in diabetic rats. Sperm LPO, H2O2 and NO levels, FBG and HbA1c were lower while TAC, SOD, CAT, GPx and epididymal sperm density were higher in diabetic rats receiving C. borivilianum root extract treatment. C. borivilianum root exhibited strong in-vitro free radical scavenging activity which may be due to the phenolic compound.ConclusionsC. borivilianum root extract prevents impairment in sperm characteristics and morphology via preventing elevation of oxidative stress, apoptosis and free radicals levels of the sperm in diabetes. These effects may be achieved through maintaining sperm antioxidant level which could be related to free radical scavenging activity of the root extract by phenolic compounds. These effects could also be due to ability of the extract to maintain near normal serum FBG and HBA1c levels in diabetes.

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“…Phyllanthus amarus belongs to the Euphorbiaceae family, which has been used to treat problems related to the genitourinary tracts [ 47 ]. Recent studies have also revealed antidiabetic activity of this extract [ 26 , 48 ]. It is notable that Phyllanthus amarus exhibit considerable α-amylase inhibitory activities, which may suppress postprandial glucose [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Inhibitory effect of herbal medicines and their trapping abilities against methylglyoxal-derived advanced glycation end-products

Sompong¹

2015

BMC Complement Altern Med

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BackgroundMethylglyoxal (MG) is one of the most reactive glycating agents, which result the formation of advanced glycation end-products (AGEs) that have been implicated in the progression of age-related diseases. Inhibition of MG-induced AGE formation is the imperative approach for alleviating diabetic complications. The objective of this study was to investigate the MG-trapping abilities of herbal medicines and their inhibitory activities on the formation of MG-derived AGEs.MethodsThe aqueous extract of herbal medicines was measured for the content of total phenolic compounds and the antioxidant activity by Folin-Ciocalteu assay and the 1,1-diphenyl 2-picrylhydrazyl (DPPH) radical scavenging activity, respectively. The extracts were investigated the MG-trapping ability by high performance liquid chromatography (HPLC). The extracts were incubated with BSA and MG at 37 °C for 1 day. The formation of MG-derived AGEs was measured.ResultsTotal phenolic compounds of eleven herbal medicines showed marked variations, ranging from 12.16 to 272.36 mg gallic acid equivalents/g extract. All extracts (1 mg/mL) markedly exhibited the DPPH radical scavenging activity (0.31–73.52 %) and the MG-trapping abilities (13.97–58.97 %). In addition, they also inhibited the formation of MG-derived AGEs by 4.01–79.98 %. The results demonstrated that Rhinacanthus nasutus, Syzygium aromaticum, and Phyllanthus amarus were the potent inhibitors against the formation of MG-derived AGEs. The positive correlations between the contents of phenolics and % MG trapping (r = 0.912, p < 0.01) and % inhibition of MG-derived AGEs (r = 0.716, p < 0.01) were observed in the study. Furthermore, there was a moderate positive correlation between % MG trapping and % inhibition of MG-derived AGEs (r =0.584, p < 0.01).ConclusionsRhinacanthus nasutus, Syzygium aromaticum, and Phyllanthus amarus could reduce the formation of MG-derived AGEs through their MG-trapping abilities. These findings are relevant for focusing on potential herbal medicines to prevent or ameliorate AGE-mediated diabetic complications.

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The evaluation of the hypoglycemic effect of soft drink leaf extract of Phyllanthus amarus (Euphorbiaceae) in rats

Cited by 16 publications

References 32 publications

Investigation of antidiabetic action ofAntidesma buniusextract in type 1 diabetes

Investigation of antidiabetic action ofAntidesma buniusextract in type 1 diabetes

Chlorophytum borivilianum (Safed Musli) root extract prevents impairment in characteristics and elevation of oxidative stress in sperm of streptozotocin-induced adult male diabetic Wistar rats

Inhibitory effect of herbal medicines and their trapping abilities against methylglyoxal-derived advanced glycation end-products

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