The evolving atopic dermatitis management landscape

Sahni, Vikram N; Balogh, Esther A.; Strowd, Lindsay C.; Feldman, Steven R.

doi:10.1080/14656566.2021.1999412

Cited by 16 publications

(7 citation statements)

References 68 publications

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“…Canine atopic dermatitis diagnosis and treatment remain challenging due to the lack of specialized laboratory tests and medications [9]. Thus, doctors employ varying strategies to treat the condition, such as prescribing corticosteroids, emollients, antihistamines, antibiotics, and immunomodulatory drugs [10].…”

Section: Introductionmentioning

confidence: 99%

Detecting common allergens in dogs with atopic dermatitis in South Korean Provinces using a serological immunoglobulin E-specific allergen test

Adam

Park²,

Cho³

et al. 2022

Vet World

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Background and Aim: Canine atopic dermatitis (CAD) is a hereditary susceptibility to the development of allergic symptoms in response to repeated exposure to generally innocuous substances known as "allergens." Allergens can be plants, animals, mold, mites, or milk. At present, serological enzyme-linked immunoassay (ELISA) kits are used for immunoglobulin E (IgE)-specific allergen detection due to their simplicity and accuracy. This study aimed to detect allergens in dogs with CAD and determine how they differ according to season, breed, age, and sex using a serological test in six provinces in South Korea for 12 months. This will allow practitioners to easily understand the risk factors related to CAD. Materials and Methods: In this study, IgE allergen-specific ELISA kits were used. The allergens were detected in serum samples collected from different regions considering season, sex, breed, and age. Allergens were divided into the following Ten categories: 1. Dairy, yeast, and egg, 2. grains, 3. vegetables, 4. meat, 5. seafood, 6. animals, 7. mold, 8. insects, 9. mites, and 10. trees. Results: The percentage of allergens detected in males (54.8%) was higher than that of females (45.2%); 54.2% of allergens occurred in 3-year-old dogs or older. Moreover, regarding frequency, 65.6% of overall allergens occur during autumn; Chungcheongnam-do and Jeollabuk-do showed 20.7% and 20.9%, respectively. Additionally, among allergens categories, notable allergen occurrence was as follows: 38.3% corn; 28.7% potatoes; 22.7% duck; 24.4%,codfish; 31.2% animal wool; 95.6% Aspergillus fumigatus; 31.9% flea; 41.8% oak; and 25.0% sheep's sorrel grass. Conclusion: This study showcases the frequency of 60 allergens in six provinces detected in dogs with CAD; most likely from food or the environment using serological ELISA kits. Environmental sensitizer results can be considered for humans suffering from allergies to avoid a similar environment. A large-scale study can be performed to evaluate the allergens in the state. However, neither a skin test nor feed analysis was conducted, which is a limitation of this study.

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Section: Introductionmentioning

confidence: 99%

Detecting common allergens in dogs with atopic dermatitis in South Korean Provinces using a serological immunoglobulin E-specific allergen test

Adam

Park²,

Cho³

et al. 2022

Vet World

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“…Furthermore, the safety profile is a key aspect in a chronic disease such as atopic dermatitis [27]. Both traditional and innovative systemic drugs are currently available or under clinical trials (Table 1); however, in many countries only cyclosporine and dupilumab are labelled for atopic dermatitis, while alitretinoin is labelled for chronic hand eczema, including atopic dermatitis of the hand [29].…”

Section: Treatmentmentioning

confidence: 99%

“…Tavecchio et al analysed the dupilumab efficacy on 221 adult atopic dermatitis patients in a reworld study [25]. The patients were stratified into six phenotypes; a consistent improvement was found for all the phenotypes, with the best results in more severe cases (especially erythroderma) [29]. On the other hand, in another Italian real-life study on 165 adult patients treated with dupilumab no statistical differences were reported between seven different atopic dermatitis clinical phenotypes [60].…”

Section: Treatmentmentioning

confidence: 99%

Clinical phenotypes of adult atopic dermatitis and related therapies

Patruno

Potestio

Napolitano

2022

Current Opinion in Allergy &Amp; Clinical Immunology

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Purpose of reviewTo report current knowledge on the different clinical phenotypes of adult atopic dermatitis. Possible therapeutic intervention in relation to phenotype is also evaluated. Recent findingsAtopic dermatitis is a chronic inflammatory disease affecting up to 10% of adults. It can manifest with different clinical phenotypes, causing diagnostic difficulties. Long-term is often required and systemic drugs are needed for moderate-to-severe forms. However, few drugs are registered for atopic dermatitis in many countries. Furthermore, limited data exist regarding the treatment in relation to individual clinical phenotypes. SummaryCurrently, the most relevant data are those for cyclosporine, alitretinoin, and dupilumab. Cyclosporine and dupilumab showed to be effective in the treatment of atopic dermatitis, although in trials and real-life experiences the different phenotypes treated are usually not reported. However, cyclosporine appears to be effective in prurigo nodularis. Alitretinoin is reported to be particularly efficacious for atopic dermatitis of the hands, while it is ineffective for other locations of the disease. Dupilumab demonstrated its efficacy in prurigo nodularis and nummular eczema phenotypes of atopic dermatitis; moreover, especially in elderly patients, its effectiveness seems to be faster if the folds of the limbs are involved.

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“…Atopic dermatitis (AD) is a chronic-relapsing inflammatory skin condition with variable clinical manifestations, depending on its activity phase [ 105 , 106 ]. AD is characterised by a strict differentiation of CD4 lymphocytes towards the Th2 lineage, thus leading to the increased production of IL-4, IL-5, and IL-13 within the skin.…”

Section: Skin Aquaporins In Inflammatory Dermatological Diseasesmentioning

confidence: 99%

Aquaporins Are One of the Critical Factors in the Disruption of the Skin Barrier in Inflammatory Skin Diseases

Tricarico

Mentino

Marco

et al. 2022

IJMS

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The skin is the largest organ of the human body, serving as an effective mechanical barrier between the internal milieu and the external environment. The skin is widely considered the first-line defence of the body, with an essential function in rejecting pathogens and preventing mechanical, chemical, and physical damages. Keratinocytes are the predominant cells of the outer skin layer, the epidermis, which acts as a mechanical and water-permeability barrier. The epidermis is a permanently renewed tissue where undifferentiated keratinocytes located at the basal layer proliferate and migrate to the overlying layers. During this migration process, keratinocytes undertake a differentiation program known as keratinization process. Dysregulation of this differentiation process can result in a series of skin disorders. In this context, aquaporins (AQPs), a family of membrane channel proteins allowing the movement of water and small neutral solutes, are emerging as important players in skin physiology and skin diseases. Here, we review the role of AQPs in skin keratinization, hydration, keratinocytes proliferation, water retention, barrier repair, wound healing, and immune response activation. We also discuss the dysregulated involvement of AQPs in some common inflammatory dermatological diseases characterised by skin barrier disruption.

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The evolving atopic dermatitis management landscape

Cited by 16 publications

References 68 publications

Detecting common allergens in dogs with atopic dermatitis in South Korean Provinces using a serological immunoglobulin E-specific allergen test

Detecting common allergens in dogs with atopic dermatitis in South Korean Provinces using a serological immunoglobulin E-specific allergen test

Clinical phenotypes of adult atopic dermatitis and related therapies

Aquaporins Are One of the Critical Factors in the Disruption of the Skin Barrier in Inflammatory Skin Diseases

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