Rapid urbanization and industrialization have brought about regional prosperity and pressure on the ecological environment, and the disorder of development has led to competition among the production-living-ecology functions. How to build livable cities, optimize the spatial layout of land, and promote the coordinated development of the production-living-ecology functions in various regions has become an important issue in the sustainable development and utilization of land space. In order to study the spatiotemporal conflict and coordination of the production-living-ecology functions with respect to the dramatic developments associated with the 21st century, this study took Hubei Province, which is the top-ranking economic region in China in recent years, as the study area and adopted the global entropy value method, triangle model, and coupled evaluation model to delineate an index system to measure the degree of conflict and coordination of the production-living-ecology functions in Hubei Province from 2000 to 2020, and also delineate zoning management based on statistical yearbook data. The results showed the following: (1) With respect to the time scale, the indices of the production-living-ecology functions in Hubei Province increased year by year, and the degree of coordination also increased yearly, from the stage of disorder with certain conflict to the stage of coordination with a high level of coupling. (2) On the spatial scale, the development of production-living-ecology functions in Hubei Province was unbalanced, which may be related to the overall development strategy of “two circles and one belt” in Hubei Province, with the eastern part of the province having a higher degree of coordination of the production-living-ecology functions and the western part having a lower degree of coordination. (3) Among the production-living-ecology functions, the ecological function of Hubei Province as a whole exhibited minimal change and maintained stable development, while the living and production functions underwent considerable development, indicating that Hubei Province has protected the orderly development of the ecological environment in the process of urbanization and new industrialization. (4) According to the development and coordination of the production-living-ecology functions in each region of Hubei Province, four development management zones were created: high-quality development zone, secondary development zone, balanced development zone, and development potential zone. Finally, policy suggestions are given for each zone.