The exon 16-3t variant of the sulphonylurea receptor gene is not a risk factor for Type II diabetes mellitus in the Dutch Breda cohort

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doi:10.1007/s001250051358

Cited by 12 publications

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“…In a large study of Caucasians from the UK Prospective Diabetes Study (UKPDS) no association was seen between either exon 16 or 18 variant and diabetes. [16] The same was observed in independent populations from Netherlands,[17] Dutch Breda cohort,[18] and Japanese population. [19] A meta-analysis of reported association studies in Caucasian populations involving more than 7,000 subjects for the exon 16 and 18 variants did not support a substantial role of these two variants in the etiology of common type 2 diabetes.…”

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confidence: 63%

Association study of the ABCC8 gene variants with type 2 diabetes in south Indians

Venkatesan¹,

Bodhini²,

Nagarajan³

et al. 2014

Indian J Hum Genet

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BACKGROUND:The ABCC8 gene which encodes the sulfonylurea receptor plays a major role in insulin secretion and is a potential candidate for type 2 diabetes. The -3c → t (rs1799854) and Thr759Thr (C → T, rs1801261) single nucleotide polymorphisms (SNPs) of the ABCC8 gene have been associated with type 2 diabetes in many populations. The present study was designed to investigate the association of these two SNPs in an Asian Indian population from south India.MATERIALS AND METHODS:A total of 1,300 subjects, 663 normal glucose tolerant (NGT) and 637 type 2 diabetic subjects were randomly selected from the Chennai Urban Rural Epidemiology Study (CURES). The -3c → t and Thr759Thr were genotyped in these subjects using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and a few variants were confirmed by direct sequencing.RESULTS:The frequency of the ‘t’ allele of the -3c → t SNP was found to be 0.27 in NGT and 0.29 in type 2 diabetic subjects (P = 0.44). There was no significant difference in the genotypic frequency between the NGT and type 2 diabetic group (P = 0.18). Neither the genotypic frequency nor the allele frequency of the Thr759Thr polymorphism was found to differ significantly between the NGT and type 2 diabetic groups.CONCLUSION:The -3c → t and the Thr759Thr polymorphisms of the ABCC8 gene were not associated with type 2 diabetes in this study. However, an effect of these genetic variants on specific unidentified sub groups of type 2 diabetes cannot be excluded.

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