The Exposome and Asthma

Subramanian, Ahila; Khatri, Sumita

doi:10.1016/j.ccm.2018.10.017

Cited by 23 publications

(11 citation statements)

References 129 publications

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“…Natural ventilation occurs when windows and doors are open, and mechanical ventilation occurs when rooms or appliances are connected to the outdoors through ductwork. 31 To improve indoor air quality 34 and reduce respiratory disease exacerbations, 35 patients can be advised to do the following: • Use an air purifi er • Close windows that face roadways • Remove shoes at entryways • Properly ventilate a gas stove or switch to an electric stove • Evaluate chemicals used in home cleaning.…”

Section: Air Quality Basicsmentioning

confidence: 99%

How does climate change impact our patients?

Gordon

Mehta

Isaacson

et al. 2023

CCJM

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Section: Air Quality Basicsmentioning

confidence: 99%

How does climate change impact our patients?

Gordon

Mehta

Isaacson

et al. 2023

CCJM

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“…This is the exposome approach developed in 2005 but still neglected in the UK. It is another example of a lagging approach in England that has some validity to assessing possible impacts of air pollution along with a range of other factors [123][124][125].…”

Section: Inequalities and Environmental Justice In Shale Explorationmentioning

confidence: 99%

Lagging and Flagging: Air Pollution, Shale Gas Exploration and the Interaction of Policy, Science, Ethics and Environmental Justice in England

Watterson

Dinan

2020

IJERPH

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The science on the effects of global climate change and air pollution on morbidity and mortality is clear and debate now centres around the scale and precise contributions of particular pollutants. Sufficient data existed in recent decades to support the adoption of precautionary public health policies relating to fossil fuels including shale exploration. Yet air quality and related public health impacts linked to ethical and environmental justice elements are often marginalized or missing in planning and associated decision making. Industry and government policies and practices, laws and planning regulations lagged well behind the science in the United Kingdom. This paper explores the reasons for this and what shaped some of those policies. Why did shale gas policies in England fail to fully address public health priorities and neglect ethical and environmental justice concerns. To answer this question, an interdisciplinary analysis is needed informed by a theoretical framework of how air pollution and climate change are largely discounted in the complex realpolitik of policy and regulation for shale gas development in England. Sources, including official government, regulatory and planning documents, as well as industry and scientific publications are examined and benchmarked against the science and ethical and environmental justice criteria. Further, our typology illustrates how the process works drawing on an analysis of official policy documents and statements on planning and regulatory oversight of shale exploration in England, and material from industry and their consultants relating to proposed shale oil and gas development. Currently the oil, gas and chemical industries in England continue to dominate and influence energy and feedstock-related policy making to the detriment of ethical and environmental justice decision making with significant consequences for public health.

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“…No matter which strategy is applied, an exposome study should be assumption-directed. For example, if the study is designed to explore the role of environmental factors on asthma, information on all exposures that could potentially affect airway inflammation should be collected [22]. However, this will come at the cost of not identifying rare exposures that are not yet known to correlate with a given disease; whereas, if the study aims to discover effects of exposures on unexpected health outcomes, it is desirable to include all measurable exposures in a given time period.…”

Section: How To Perform An Exposome Study?mentioning

confidence: 99%

Tackling the Complexity of the Exposome: Considerations from the Gunma University Initiative for Advanced Research (GIAR) Exposome Symposium

et al. 2019

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The attempt to describe complex diseases by solely genetic determination has not been successful. There is increasing recognition that the development of disease is often a consequence of interactions between multiple genetic and environmental factors. To date, much of the research on environmental determinants of disease has focused on single exposures generally measured at a single time point. In order to address this limitation, the concept of the exposome has been introduced as a comprehensive approach, studying the full complement of environmental exposures from conception onwards. However, exposures are vast, dynamic, and diverse, and only a small proportion can be reasonably measured due to limitations in technology and feasibility. In addition, the interplay between genes and exposure as well as between different exposures is complicated and multifaceted, which leads to difficulties in linking disease or health outcomes with exposures. The large numbers of collected samples require well-designed logistics. Furthermore, the immense data sets generated from exposome studies require a significant computational investment for both data analysis and data storage. This report summarizes discussions during an international exposome symposium held at Gunma University in Japan regarding the concept of the exposome, challenges in exposome research, and future perspectives in the field.

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The Exposome and Asthma

Cited by 23 publications

References 129 publications

How does climate change impact our patients?

How does climate change impact our patients?

Lagging and Flagging: Air Pollution, Shale Gas Exploration and the Interaction of Policy, Science, Ethics and Environmental Justice in England

Tackling the Complexity of the Exposome: Considerations from the Gunma University Initiative for Advanced Research (GIAR) Exposome Symposium

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