The exposome in practice: an exploratory panel study of biomarkers of air pollutant exposure in Chinese people aged 60–69 years (China BAPE Study)

Tang, Song; Li, Tiantian; Fang, Jianlong; Chen, Renjie; Cha, Yu‐E; Wang, Yanwen; Zhu, Mu; Zhang, Yi; Chen, Yuanyuan; Du, Yanjun; Yu, Tianwei; Thompson, David C.; Pollitt, Krystal J. Godri; Vasiliou, Vasilis; Ji, John S.; Kan, Haidong; Zhang, Junfeng Jim; Shi, Xiaoming

doi:10.1016/j.envint.2021.106866

Cited by 29 publications

(18 citation statements)

References 142 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The participants were from the Biomarkers of Air Pollutant Exposure in Chinese people aged 60–69 years (China BAPE) panel study at Jinan, Shandong Province, which is one of the most polluted cities in northern China with a permanent population of over 9 million (Figure S1). The detailed study design can be found in previous publications. − In brief, a healthy elderly population aged 60–69 (50% female) was recruited by screening the health records and physical examinations provided by the Ankang Community Hospital. People with acute or chronic illnesses, smoking, alcohol abuse, and drug use were excluded.…”

Section: Methodsmentioning

confidence: 99%

Emerging and Legacy Per- and Polyfluoroalkyl Substances in an Elderly Population in Jinan, China: The Exposure Level, Short-Term Variation, and Intake Assessment

Jia

Fang

et al. 2022

Environ. Sci. Technol.

Self Cite

View full text Add to dashboard Cite

Human exposure to per- and polyfluoroalkyl substances (PFASs) has gained worldwide attention due to their widespread presence in the environment and adverse health effects, but the exposure assessment in the elderly is still lacking. This study aimed to assess exposures to 3 emerging PFASs (chlorinated polyfluoroalkyl ether sulfonic acids, Cl-PFESAs) and 15 legacy PFASs. The temporal variability of internal exposures and intake amounts of these PFASs were evaluated among a population of 76 healthy elderly adults (age: 60–69) in Jinan, China over 5 consecutive months. Fifteen PFASs were detected in whole blood with the mean total concentration (ΣPFAS) at 20.1 ng/mL (range: 5.0–135.9 ng/mL) dominated by perfluorooctanoic acid (PFOA) (9.0 ng/mL), perfluorooctanesulfonic acid (PFOS) (5.3 ng/mL), and 6:2 Cl-PFESA (1.6 ng/mL). Across the 5 month assessment period, significant variation was only observed for short-chain (C4–C7) perfluoroalkyl carboxylic acids, and their variations ranged from 53 to 334%. The median intake of PFOA and PFOS was estimated to be 1.46 and 0.92 ng/kg bw/day, respectively. Regression analysis showed that dietary ingestion, especially fish, was likely an important exposure pathway for PFASs among the elderly adults. Various pathways (e.g., dietary, water, air, and dust) should thus be considered to fully understand human exposure to PFASs.

show abstract

Section: Methodsmentioning

confidence: 99%

Emerging and Legacy Per- and Polyfluoroalkyl Substances in an Elderly Population in Jinan, China: The Exposure Level, Short-Term Variation, and Intake Assessment

Jia

Fang

et al. 2022

Environ. Sci. Technol.

Self Cite

View full text Add to dashboard Cite

show abstract

“…More recently, the association of PM 2.5 -associated microglial activation with neurodegenerative disorders have been investigated among the elderly. In a panel study, Tang et al examined the air pollutant (including PM) exposure in Chinese people aged 60–69 years, showing that air pollution exposure could induce alterations of neurodegenerative biomarkers, such as Aβ 40 , Aβ 42 , α-synuclein, PrPC, Tau (pThr181), and the activation of microglia represented by the over-expression of S100B and microglial triggering receptor expressed on myeloid cells2 (TREM2) [ 71 ]. Our recent findings from a panel study on healthy retired adults demonstrated that PM 2.5 concentration increments were associated with increases in the biomarkers of neural damage, including a neurofilament light chain (NfL), neuron-specific enolase, and the activation of microglia (S100B) in serum [ 72 ].…”

Section: Evidence From Epidemiological Investigationsmentioning

confidence: 99%

Microglial Activation and Oxidative Stress in PM2.5-Induced Neurodegenerative Disorders

Song

Han

Wang³

et al. 2022

Antioxidants

View full text Add to dashboard Cite

Fine particulate matter (PM2.5) pollution remains a prominent environmental problem worldwide, posing great threats to human health. The adverse effects of PM2.5 on the respiratory and cardiovascular systems have been extensively studied, while its detrimental effects on the central nervous system (CNS), specifically neurodegenerative disorders, are less investigated. Neurodegenerative disorders are characterized by reduced neurogenesis, activated microglia, and neuroinflammation. A variety of studies involving postmortem examinations, epidemiological investigations, animal experiments, and in vitro cell models have shown that PM2.5 exposure results in neuroinflammation, oxidative stress, mitochondrial dysfunction, neuronal apoptosis, and ultimately neurodegenerative disorders, which are strongly associated with the activation of microglia. Microglia are the major innate immune cells of the brain, surveilling and maintaining the homeostasis of CNS. Upon activation by environmental and endogenous insults, such as PM exposure, microglia can enter an overactivated state that is featured by amoeboid morphology, the over-production of reactive oxygen species, and pro-inflammatory mediators. This review summarizes the evidence of microglial activation and oxidative stress and neurodegenerative disorders following PM2.5 exposure. Moreover, the possible mechanisms underlying PM2.5-induced microglial activation and neurodegenerative disorders are discussed. This knowledge provides certain clues for the development of therapies that may slow or halt the progression of neurodegenerative disorders induced by ambient PM.

show abstract

“…Recent studies demonstrated the feasibility of exposome-wide association studies (ExWAS), e.g. extensive effect biomarker and biomarker discovery of air pollutant exposure (Tang et al 2021) and linking metabolic profiling and exposure to perfluoroalkyl substances (Alderete et al 2019). However, to capture the metabolome and the chemical exposome several independent measurements were required, increasing the measurement time compared to our 15 min LC-HRMS/MS run covering both polar metabolites and the primarily apolar xenobiotics.…”

Section: Limitationsmentioning

confidence: 99%

Integrated exposomics/metabolomics for rapid exposure and effect analyses

Flasch

Fitz

Rampler

et al. 2022

Preprint

View full text Add to dashboard Cite

Environmental drivers of disease susceptibility, referred to as the exposome in its totality, are poorly understood. Measuring the myriad of chemicals that humans are exposed to is immensely challenging and identifying disrupted metabolic pathways is an even more complex task. Here, we present a novel technological approach for the comprehensive, rapid and integrated analysis of the endogenous human metabolome and the chemical exposome. By combining reverse-phase and hydrophilic interaction liquid chromatography and fast polarity switching, molecules with highly diverse chemical structures can be analyzed in 15 minutes with a single analytical run. Standard reference materials and authentic standards were evaluated to critically benchmark performance. Highly sensitive median limits of detection with 0.04 µM for >140 quantitatively assessed endogenous metabolites and 0.08 ng/mL for the >100 model xenobiotics were obtained. To prove the dual-column approach’s applicability, real-life samples from sub-Saharan Africa (high exposure scenario) and Europe (low exposure scenario) were assessed in a targeted and non-targeted manner. Our LC-HRMS approach demonstrates the feasibility to quantitatively and simultaneously assess the endogenous metabolome and the chemical exposome for the high-throughput measurement of environmental drivers of disease.

show abstract

The exposome in practice: an exploratory panel study of biomarkers of air pollutant exposure in Chinese people aged 60–69 years (China BAPE Study)

Cited by 29 publications

References 142 publications

Emerging and Legacy Per- and Polyfluoroalkyl Substances in an Elderly Population in Jinan, China: The Exposure Level, Short-Term Variation, and Intake Assessment

Emerging and Legacy Per- and Polyfluoroalkyl Substances in an Elderly Population in Jinan, China: The Exposure Level, Short-Term Variation, and Intake Assessment

Microglial Activation and Oxidative Stress in PM2.5-Induced Neurodegenerative Disorders

Integrated exposomics/metabolomics for rapid exposure and effect analyses

Contact Info

Product

Resources

About